| Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid beta-oxidation to alleviate diabetic cardiomyopathy. | Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy.
Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, Zhang Y, Cao Y, Wu DX, Shu XF, Xin L, Wang H, Zhang X, Li CY, Gu XM, Zhang X, Sun DD., Free PMC Article | 12/20/2023 |
| IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. | IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models.
Ferraro F, Steinle A, Narasimhan H, Bleilevens A, Stolzenberg PM, Braunschweig T, Stickeler E, Maurer J., Free PMC Article | 02/16/2023 |
| lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p. | lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p.
Xiao T, Sun C, Xiao Y, Li Y., Free PMC Article | 08/28/2021 |
| The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling. | The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling.
Joshi H, Lunz B, Peters A, Zölch M, Berberich I, Berberich-Siebelt F. | 07/31/2021 |
| IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes. | IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Zhou H, Wang H, Yu M, Schugar RC, Qian W, Tang F, Liu W, Yang H, McDowell RE, Zhao J, Gao J, Dongre A, Carman JA, Yin M, Drazba JA, Dent R, Hine C, Chen YR, Smith JD, Fox PL, Brown JM, Li X., Free PMC Article | 01/9/2021 |
| miR-497 can partially negatively regulate the activation of IRAK2-NF-kappaB pathway in LPS-induced inflammatory responses | miR-497a-5p attenuates lipopolysaccharide-induced inflammatory injury by targeting IRAK2.
Guo S, Chen Y, Liu J, Yang J, Yang C, Zhang T, Jiang K, Wu Z, Shaukat A, Deng G. | 06/13/2020 |
| In summary, lipopolysaccharide activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation. | IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.
Zhou H, Bulek K, Li X, Herjan T, Yu M, Qian W, Wang H, Zhou G, Chen X, Yang H, Hong L, Zhao J, Qin L, Fukuda K, Flotho A, Gao J, Dongre A, Carman JA, Kang Z, Su B, Kern TS, Smith JD, Hamilton TA, Melchior F, Fox PL, Li X., Free PMC Article | 06/23/2018 |
| These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway. | Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling.
Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC., Free PMC Article | 01/11/2014 |
| Our results establish that the IRAK2-TRAF6 interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells | Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
Pauls E, Nanda SK, Smith H, Toth R, Arthur JSC, Cohen P., Free PMC Article | 11/16/2013 |
| IRAK2 plays a key role in the TLR9-mediated transcriptional regulation of Irak-m expression by sustaining activation of PKD1 and NF-kappaB | Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA.
Kim YI, Park JE, Kwon KH, Hong CY, Yi AK., Free PMC Article | 02/2/2013 |
| IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF. | IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.
Smith PM, Jacque B, Conner JR, Poltorak A, Stadecker MJ., Free PMC Article | 02/11/2012 |
| the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase signaling, which regulates cytokine and chemokine production at posttranscriptional levels. | The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation.
Yin W, Wan Y, Kim TW, Yao P, Xiao H, Zhou H, Xiao J, Fox P, Li X., Free PMC Article | 08/27/2011 |
| IRAK2 is a negative regulator of Toll-like receptor (TLR)9-induced interferon production in plasmacytoid dendritic cells. | The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.
Wan Y, Kim TW, Yu M, Zhou H, Yamashita M, Kang Z, Yin W, Wang JA, Thomas J, Sen GC, Stark GR, Li X., Free PMC Article | 05/21/2011 |
| miR-146a, up-regulated during viral infection, is a negative regulator of the RIG-I-dependent antiviral pathway by targeting TRAF6, IRAK1, and IRAK2. | MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.
Hou J, Wang P, Lin L, Liu X, Ma F, An H, Wang Z, Cao X. | 01/21/2010 |
| Data demonstrate that IRAK-2 is an essential component of the early TLR response in MOLF/Ei mice and show a distinct pathway of p38 and NF-kappaB activation in this model organism. | A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice.
Conner JR, Smirnova II, Poltorak A., Free PMC Article | 01/21/2010 |
| These results reveal that IRAK2 is required for LPS-mediated post-transcriptional control of cytokine and chemokine expression, which plays an essential role in TLR4-induced septic shock. | Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.
Wan Y, Xiao H, Affolter J, Kim TW, Bulek K, Chaudhuri S, Carlson D, Hamilton T, Mazumder B, Stark GR, Thomas J, Li X., Free PMC Article | 01/21/2010 |
| TRAF6 and interleukin receptor-associated kinase 2 are novel binding partners for PS1, and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage | Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
Elzinga BM, Twomey C, Powell JC, Harte F, McCarthy JV. | 01/21/2010 |
| Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll-like receptors signaling. | The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory.
Hardy MP, O'Neill LA. | 01/21/2010 |