| Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro. | Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro.
Choudhry M, Gamallat Y, Ghosh S, Bismar TA., Free PMC Article | 08/31/2023 |
| CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer. | CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.
Song Y, Sun K, Gong L, Shi L, Qin T, Wang S, Deng W, Chen W, Zheng F, Li G. | 01/21/2023 |
| CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4. | CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4.
Lee K, Zheng Q, Lu Q, Xu F, Qin G, Zhai Q, Hong R, Chen M, Deng W, Wang S., Free PMC Article | 03/26/2022 |
| CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma. | CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma.
Wang X, Dong J, Li X, Cheng Z, Zhu Q. | 12/25/2021 |
| Overproduced CPSF4 Promotes Cell Proliferation and Invasion via PI3K-AKT Signaling Pathway in Oral Squamous Cell Carcinoma. | Overproduced CPSF4 Promotes Cell Proliferation and Invasion via PI3K-AKT Signaling Pathway in Oral Squamous Cell Carcinoma.
Zhang M, Lin H, Ge X, Xu Y. | 05/22/2021 |
| MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4; results suggest that the miR-4458-CPSF4-COX-2-hTERT axis might serve as a potential target for the treatment of breast cancer patients | MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.
Wu J, Miao J, Ding Y, Zhang Y, Huang X, Zhou X, Tang R. | 03/28/2020 |
| The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Clerici M, Faini M, Aebersold R, Jinek M., Free PMC Article | 08/11/2018 |
| Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. | Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.
Wang BX, Brown EG, Fish EN. | 08/19/2017 |
| Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. | Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression.
Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, Li W, Liao Y, Feng X, Hao J, Gao Y, Yu W, Chen Y, Zhang C, Guo W, Tang B, Deng W. | 07/29/2017 |
| These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. | Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster.
Shimberg GD, Michalek JL, Oluyadi AA, Rodrigues AV, Zucconi BE, Neu HM, Ghosh S, Sureschandra K, Wilson GM, Stemmler TL, Michel SL., Free PMC Article | 12/17/2016 |
| unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA | CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.
Chan SL, Huppertz I, Yao C, Weng L, Moresco JJ, Yates JR 3rd, Ule J, Manley JL, Shi Y., Free PMC Article | 01/3/2015 |
| CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity. | CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.
Chen W, Qin L, Wang S, Li M, Shi D, Tian Y, Wang J, Fu L, Li Z, Guo W, Yu W, Yuan Y, Kang T, Huang W, Deng W., Free PMC Article | 12/20/2014 |
| Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A). | Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus.
Ai H, Zhang L, Chang AK, Wei H, Che Y, Liu H. | 11/8/2014 |
| CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma. | Upregulation of cleavage and polyadenylation specific factor 4 in lung adenocarcinoma and its critical role for cancer cell survival and proliferation.
Chen W, Guo W, Li M, Shi D, Tian Y, Li Z, Wang J, Fu L, Xiao X, Liu QQ, Wang S, Huang W, Deng W., Free PMC Article | 10/25/2014 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. | The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.
Twu KY, Kuo RL, Marklund J, Krug RM., Free PMC Article | 01/21/2010 |