| Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization and in vivo migration of neutrophils. | Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization and in vivo migration of neutrophils.
Metzemaekers M, Vandendriessche S, Berghmans N, Gouwy M, Proost P. | 11/21/2020 |
| The data point to a surprising scenario where local assembly and biased polymerization generate the slow axonal transport of actin without involvement of microtubules (MTs) or MT-based motors. | Processive flow by biased polymerization mediates the slow axonal transport of actin.
Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P, Roy S., Free PMC Article | 10/26/2019 |
| NIK is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling. | NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A. | 10/5/2019 |
| It is shown that TNF-alpha signaling regulates the phosphorylation of serine-5 and -7 in L-plastin which increases the actin bundling capacity of L-plastin and hence the formation of nascent sealing zones in mouse osteoclasts. | L-plastin phosphorylation regulates the early phase of sealing ring formation by actin bundling process in mouse osteoclasts.
Chellaiah MA, Ma T, Majumdar S., Free PMC Article | 09/21/2019 |
| The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression. | Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
Lu Y, Zhang Y, Pan MH, Kim NH, Sun SC, Cui XS., Free PMC Article | 04/21/2018 |
| Interactions with phosphatidylinositol 4,5-bisphosphate decrease the actin polymerizing activity of Ig domain 3 of palladin (Palld-Ig3). | Phosphoinositide Binding Inhibits Actin Crosslinking and Polymerization by Palladin.
Yadav R, Vattepu R, Beck MR., Free PMC Article | 06/24/2017 |
| Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure. | A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.
Vincent PF, Bouleau Y, Petit C, Dulon D., Free PMC Article | 08/27/2016 |
| These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus. | α-Actinin involvement in Z-disk assembly during skeletal muscle C2C12 cells in vitro differentiation.
Salucci S, Baldassarri V, Falcieri E, Burattini S. | 10/24/2015 |
| The C-terminal polybasic region of CYTH2 participates in interacting directly with the EFh2 domain of ACTN1. | Arf6 guanine-nucleotide exchange factor, cytohesin-2, interacts with actinin-1 to regulate neurite extension.
Torii T, Miyamoto Y, Nakamura K, Maeda M, Yamauchi J, Tanoue A. | 03/1/2014 |
| Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice. | Intronic parent-of-origin dependent differential methylation at the Actn1 gene is conserved in rodents but is not associated with imprinted expression.
Calaway JD, Domínguez JI, Hanson ME, Cambranis EC, Pardo-Manuel de Villena F, de la Casa-Esperon E., Free PMC Article | 07/27/2013 |
| alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix | Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.
Roca-Cusachs P, del Rio A, Puklin-Faucher E, Gauthier NC, Biais N, Sheetz MP., Free PMC Article | 07/13/2013 |
| Alpha-actinin interaction with syndecan-4 has a role in stabilising cell-matrix adhesion. | Alpha-actinin interactions with syndecan-4 are integral to fibroblast-matrix adhesion and regulate cytoskeletal architecture.
Okina E, Grossi A, Gopal S, Multhaupt HA, Couchman JR. | 04/27/2013 |
| the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function | Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics.
Beck H, Flynn K, Lindenberg KS, Schwarz H, Bradke F, Di Giovanni S, Knöll B., Free PMC Article | 12/22/2012 |
| EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines | Somatodendritic localization of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6, and its possible interaction with alpha-actinin in dendritic spines.
Sakagami H, Honma T, Sukegawa J, Owada Y, Yanagisawa T, Kondo H. | 01/21/2010 |
| vinculin engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin binding sites to swing out, which are then sufficient to bind to and activate vinculin | The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.
Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T. | 01/21/2010 |
| there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning | Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor.
Cabello N, Remelli R, Canela L, Soriguera A, Mallol J, Canela EI, Robbins MJ, Lluis C, Franco R, McIlhinney RA, Ciruela F. | 01/21/2010 |