| [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. | [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Chen W, DU H, Sha Y, Zhou Y, Liang J, Chen Y, Ma Q, Wu X, Qian G., Free PMC Article | 11/2/2023 |
| TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis. | TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis.
Yi SJ, Jang YJ, Lee S, Cho SJ, Kang K, Park JI, Chae HJ, Kim HR, Kim K., Free PMC Article | 08/22/2023 |
| Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. | Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury.
Ma L, Liao L, Zhou N, Tao H, Zhou H, Tan Y, Chen W, Cao F, Chen X., Free PMC Article | 03/21/2023 |
| TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury. | TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
Zhou H, Dai Z, Li J, Wang J, Zhu H, Chang X, Wang Y. | 02/25/2023 |
| TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1alpha. | TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Xie H, Shi Y, Zhou Y, Liu H. | 10/8/2022 |
| [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression]. | [Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression].
Chen W, DU H, Qian G, Zhou Y, Chen Y, Ma Q, Wu X, Sha Y., Free PMC Article | 05/7/2022 |
| BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3. | BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3.
Wang J, Wang X, Du W, Xue Z, Huang W, Guan Z, Wang H. | 04/9/2022 |
| TMBIM6 regulates redox-associated posttranslational modifications of IRE1alpha and ER stress response failure in aging mice and humans. | TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans.
Bhattarai KR, Kim HK, Chaudhary M, Ur Rashid MM, Kim J, Kim HR, Chae HJ., Free PMC Article | 12/18/2021 |
| Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. | Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G. | 09/11/2021 |
| Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion. | Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion.
Philippaert K, Roden M, Lisak D, Bueno D, Jelenik T, Radyushkin K, Schacht T, Mesuere M, Wüllner V, Herrmann AK, Baumgart J, Vennekens R, Methner A., Free PMC Article | 06/12/2021 |
| DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis. | DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.
Zhou H, Toan S, Zhu P, Wang J, Ren J, Zhang Y. | 10/31/2020 |
| ER stress modulated by Tmbim6 would play important roles in patterned dental hard tissue formation in mice molar | An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar.
Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY. | 06/6/2020 |
| Deregulated BI1 via the xanthine oxidase/reactive oxygen species /F-actin pathways plays a causative role in the development of cardiac microvascular reperfusion injury. | BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F-actin pathways.
Zhou H, Wang J, Hu S, Zhu H, Toanc S, Ren J. | 03/21/2020 |
| BI1 functions as a novel microvascular guardian in cardiac IR injury that operates via inhibition of the Syk-Nox2-Drp1-mitochondrial fission signaling axis. | BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways.
Zhou H, Shi C, Hu S, Zhu H, Ren J, Chen Y. | 10/12/2019 |
| Targeting IRE1alpha-dependent NLRP3 inflammasome signaling with pharmacological agents or by BI-1 may represent a tangible therapeutic strategy for nonalcoholic steatohepatitis | Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.
Lebeaupin C, Vallée D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Luciano F, Luci C, Anty R, Iannelli A, Marchetti S, Kroemer G, Lacas-Gervais S, Tran A, Gual P, Bailly-Maitre B. | 02/2/2019 |
| BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production. | Effect of BI-1 on insulin resistance through regulation of CYP2E1.
Lee GH, Oh KJ, Kim HR, Han HS, Lee HY, Park KG, Nam KH, Koo SH, Chae HJ., Free PMC Article | 07/7/2018 |
| BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation. | Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion.
Lee HY, Lee GH, Bhattarai KR, Park BH, Koo SH, Kim HR, Chae HJ., Free PMC Article | 04/21/2018 |
| BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. | BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival.
Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A., Free PMC Article | 10/22/2016 |
| An endogenous protective role of BI-1 under conditions of chronic mild stress. | The protective role of Bax inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A.
Lee HY, Lee GH, Marahatta A, Lin SM, Lee MR, Jang KY, Kim KM, Lee HJ, Lee JW, Bagalkot TR, Chung YC, Lee YC, Kim HR, Chae HJ., Free PMC Article | 10/24/2015 |
| Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. | BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.
Lee MR, Lee GH, Lee HY, Kim DS, Chung MJ, Lee YC, Kim HR, Chae HJ., Free PMC Article | 10/25/2014 |
| BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response. | Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice.
Kim JH, Lee ER, Jeon K, Choi HY, Lim H, Kim SJ, Chae HJ, Park SH, Kim S, Seo YR, Kim JH, Cho SG. | 11/17/2012 |
| The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. | Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC., Free PMC Article | 08/4/2012 |
| BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation | Bax inhibitor-1 regulates the expression of P450 2E1 through enhanced lysosome activity.
Lee GH, Kim HR, Chae HJ. | 06/16/2012 |
| The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. | The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A., Free PMC Article | 03/17/2012 |
| highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. | Enhanced lysosomal activity is involved in Bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress: involvement of vacuolar H+-ATPase (V-ATPase).
Lee GH, Kim DS, Kim HT, Lee JW, Chung CH, Ahn T, Lim JM, Kim IK, Chae HJ, Kim HR., Free PMC Article | 01/28/2012 |