| TRIOBP modulates beta-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis. | TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Wang L, Zhao W, Xia C, Ma S, Li Z, Wang N, Ding L, Wang Y, Cheng L, Liu H, Yang J, Li Y, Rosas I, Yu G., Free PMC Article | 01/16/2024 |
| SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY. | SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY.
Pavešić Radonja A, Blažević Zelić S, Rubeša G, Bradshaw NJ. | 07/27/2023 |
| TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein. | TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein.
Zaharija B, Odorčić M, Hart A, Samardžija B, Marreiros R, Prikulis I, Juković M, Hyde TM, Kleinman JE, Korth C, Bradshaw NJ., Free PMC Article | 10/22/2022 |
| Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals. | Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals.
Kabahuma RI, Schubert WD, Labuschagne C, Yan D, Pepper MS, Liu XZ., Free PMC Article | 10/15/2022 |
| TRIOBP-1 overexpression caused intracellular co-sequestration of hERG signal, reduced native IKr and disrupted action potential repolarization. | Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart.
Jones DK, Johnson AC, Roti Roti EC, Liu F, Uelmen R, Ayers RA, Baczko I, Tester DJ, Ackerman MJ, Trudeau MC, Robertson GA., Free PMC Article | 10/26/2019 |
| roles of TRIO and F-actin-binding protein in human diseases | Emerging roles of TRIO and F-actin-binding protein in human diseases.
Park S, Lee H, Kim M, Park J, Kim SH, Park J., Free PMC Article | 05/18/2019 |
| Results reveal that Tara forms a functional complex with Ndel1 and alters its intracellular distribution. The Ndel1-Tara complex plays a role in regulating actin cytoskeleton organization, which is critical for cell migration. | Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration.
Hong JH, Kwak Y, Woo Y, Park C, Lee SA, Lee H, Park SJ, Suh Y, Suh BK, Goo BS, Mun DJ, Sanada K, Nguyen MD, Park SK., Free PMC Article | 05/19/2018 |
| Case Reports: novel TRIOBP mutations associated with moderate, stable hereditary hearing impairment. | Broadening the phenotype of DFNB28: Mutations in TRIOBP are associated with moderate, stable hereditary hearing impairment.
Wesdorp M, van de Kamp JM, Hensen EF, Schraders M, Oostrik J, Yntema HG, Feenstra I, Admiraal RJC, Kunst HPM, Tekin M, Kanaan M, Kremer H, Pennings RJE. | 03/10/2018 |
| Based on whole exome analysis, we identified two TRIOBP pathogenic variants (c.802_805delCAGG, p.Gln268Leufs*610 and c.5014G>T, p.Gly1672*, the first of which was novel) causative of nonsyndromic, peri- to postlingual, moderate-to-severe hearing loss in three siblings from a Polish family. | Whole exome sequencing identifies TRIOBP pathogenic variants as a cause of post-lingual bilateral moderate-to-severe sensorineural hearing loss.
Pollak A, Lechowicz U, Murcia Pieńkowski VA, Stawiński P, Kosińska J, Skarżyński H, Ołdak M, Płoski R., Free PMC Article | 12/16/2017 |
| TRIOBP-1 aggregation, therefore, appears to occur through one or more specific cellular mechanisms, which therefore have the potential to be of physiological relevance for the biological process underlying the development of chronic mental illness. | An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.
Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C., Free PMC Article | 06/24/2017 |
| We discovered two genome-wide significant SNPs. The first was novel and near ISG20. The second was in TRIOBP, a gene previously associated with prelingual nonsyndromic hearing loss. Motivated by our TRIOBP results, we also looked at exons in known hearing loss genes, and identified two additional SNPs, rs2877561 in ILDR1 and rs9493672 in EYA4 (at a significance threshold adjusted for number of SNPs in those regions). | A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.
Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR., Free PMC Article | 05/13/2017 |
| TRIOBP-1 aggregates are implicated for the first time as a biological element of the neuropathology of a subset of chronic mental illness | Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.
Bradshaw NJ, Bader V, Prikulis I, Lueking A, Müllner S, Korth C., Free PMC Article | 12/19/2015 |
| High TRIOBP expression is associated with pancreatic cancer. | The actin-bundling protein TRIOBP-4 and -5 promotes the motility of pancreatic cancer cells.
Bao J, Wang S, Gunther LK, Kitajiri S, Li C, Sakamoto T. | 03/7/2015 |
| TAP68 functions in mediating TRF1-tankyrase 1 localization to the centrosome and in mitotic regulation | The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis.
Lan J, Zhu Y, Xu L, Yu H, Yu J, Liu X, Fu C, Wang X, Ke Y, Huang H, Dou Z., Free PMC Article | 12/20/2014 |
| the centrosomal localization of Tara depended on the Thr-457 phosphorylation and the kinase activity of Plk1. | Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis.
Zhu Y, Wang C, Lan J, Yu J, Jin C, Huang H. | 12/8/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp. | Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
Appierto V, Tiberio P, Cavadini E, Casalini P, Cappelletti G, Formelli F. | 03/29/2010 |
| All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. | The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.
Yu J, Lan J, Zhu Y, Li X, Lai X, Xue Y, Jin C, Huang H. | 01/21/2010 |
| Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. | Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.
Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC, Kanaan M., Free PMC Article | 01/21/2010 |
| Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. | Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.
Riazuddin S, Khan SN, Ahmed ZM, Ghosh M, Caution K, Nazli S, Kabra M, Zafar AU, Chen K, Naz S, Antonellis A, Pavan WJ, Green ED, Wilcox ER, Friedman PL, Morell RJ, Riazuddin S, Friedman TB., Free PMC Article | 01/21/2010 |