| ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization. | ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.
Lam HY, Arumugam S, Bae HG, Wang CC, Jung S, St John AL, Hong W, Han W, Tergaonkar V., Free PMC Article | 04/16/2022 |
| ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. | ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Nyitrai H, Wang SSH, Kaeser PS., Free PMC Article | 05/22/2021 |
| Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups. | Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups.
Hagiwara A, Hamada S, Hida Y, Ohtsuka T., Free PMC Article | 02/13/2021 |
| The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase. | The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase.
Sala K, Corbetta A, Minici C, Tonoli D, Murray DH, Cammarota E, Ribolla L, Ramella M, Fesce R, Mazza D, Degano M, de Curtis I., Free PMC Article | 10/31/2020 |
| ELKS and voltage-dependent Ca(2+) channel form a potent insulin secretion complex at the vascular side of the beta cell plasma membrane for polarized Ca(2+) influx. | ELKS/Voltage-Dependent Ca(2+) Channel-β Subunit Module Regulates Polarized Ca(2+) Influx in Pancreatic β Cells.
Ohara-Imaizumi M, Aoyagi K, Yamauchi H, Yoshida M, Mori MX, Hida Y, Tran HN, Ohkura M, Abe M, Akimoto Y, Nakamichi Y, Nishiwaki C, Kawakami H, Hara K, Sakimura K, Nagamatsu S, Mori Y, Nakai J, Kakei M, Ohtsuka T. | 03/14/2020 |
| These data identify distinct roles for CAST/ELKS as positive regulators of CaV2.1 channel density. | CAST/ELKS Proteins Control Voltage-Gated Ca(2+) Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Dong W, Radulovic T, Goral RO, Thomas C, Suarez Montesinos M, Guerrero-Given D, Hagiwara A, Putzke T, Hida Y, Abe M, Sakimura K, Kamasawa N, Ohtsuka T, Young SM Jr., Free PMC Article | 11/9/2019 |
| These results suggest that CAST and ELKS work in concert to promote retinal synapse formation, transmission, and maintenance. | Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.
Hagiwara A, Kitahara Y, Grabner CP, Vogl C, Abe M, Kitta R, Ohta K, Nakamura K, Sakimura K, Moser T, Nishi A, Ohtsuka T., Free PMC Article | 09/28/2019 |
| Several studies had established that ELKS is a redundant scaffold at the active zone, and that disruption of this scaffold impairs fusion of synaptic vesicles. In non-neuronal cells, scaffolding and exocytotic functions of ELKS seem to be important for constitutive secretion of other cargo. [review] | ELKS active zone proteins as multitasking scaffolds for secretion.
Held RG, Kaeser PS., Free PMC Article | 03/16/2019 |
| SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome. | SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.
Airik R, Schueler M, Airik M, Cho J, Ulanowicz KA, Porath JD, Hurd TW, Bekker-Jensen S, Schrøder JM, Andersen JS, Hildebrandt F., Free PMC Article | 07/15/2017 |
| Our results reveal that ELKS is required for normal Ca(2+) influx at nerve terminals of inhibitory hippocampal neurons. | The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons.
Liu C, Bickford LS, Held RG, Nyitrai H, Südhof TC, Kaeser PS., Free PMC Article | 01/10/2015 |
| ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli. | ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V., Free PMC Article | 11/6/2010 |