| Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma. | Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma.
Chen C, Liu H, Li Y, Xu Q, Liu J., Free PMC Article | 01/27/2024 |
| Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women. | Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women.
Kan H, Liu H, Mu Y, Li Y, Zhang M, Cao Y, Dong Y, Li Y, Wang K, Li Q, Hu A, Zheng Y. | 05/17/2023 |
| Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types. | Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types.
Chen C, Liu H, Xu Q, Zhang X, Mu F, Liu J., Free PMC Article | 07/9/2022 |
| PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer. | PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer.
Li L, Xu F, Xie P, Yuan L, Zhou M., Free PMC Article | 10/2/2021 |
| PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies. | PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies.
Sen M, Kindsfather A, Danilova L, Zhang F, Colombo R, LaPorte MG, Kurland BF, Huryn DM, Wipf P, Herman JG., Free PMC Article | 05/15/2021 |
| Study revealed a significantly higher prevalence of PTPRT and JAK2 mutations in lung adenocarcinomas among African Americans compared with European Americans. Patients carrying these mutations have a concomitant increase in IL-6/STAT3 signaling and miR-21 expression. | Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.
Mitchell KA, Nichols N, Tang W, Walling J, Stevenson H, Pineda M, Stefanescu R, Edelman DC, Girvin AT, Zingone A, Sinha S, Bowman E, Rossi EL, Arauz RF, Jack Zhu Y, Lack J, Weingartner E, Waterfall JJ, Pine SR, Simmons J, Meltzer P, Ryan BM., Free PMC Article | 04/4/2020 |
| A novel de novo 20q13.11q13.12 microdeletion was found in a boy with neurodevelopmental disorders. The established function of the PTPRT gene suggests that haploinsuficiency of this gene may result in the clinical features observed in our patient: stereotype movements, nervous tics, social and emotional disturbances and attention-span deficits. | A novel de novo 20q13.11q13.12 microdeletion in a boy with neurodevelopmental disorders - case report.
Bernaciak J, Wiśniowiecka-Kowalnik B, Castañeda J, Kutkowska-Kaźmierczak A, Nowakowska B., Free PMC Article | 07/13/2019 |
| The single cell genotyping not only confirmed the co-occurrence of the PTPRT, CAND1 and DOCK6 mutations in the same AML clone but also revealed a clonal hierarchy, as the PTPRT mutation was likely acquired after the CAND1 and DOCK6 mutations. | Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis.
Niemöller C, Renz N, Bleul S, Blagitko-Dorfs N, Greil C, Yoshida K, Pfeifer D, Follo M, Duyster J, Claus R, Ogawa S, Lübbert M, Becker H. | 07/22/2017 |
| PTPRT promoter methylation is significantly associated with sensitivity to STAT3 inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 inhibitors in clinical development | Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.
Peyser ND, Freilino M, Wang L, Zeng Y, Li H, Johnson DE, Grandis JR., Free PMC Article | 08/6/2016 |
| Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor. | The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population.
Yao Y, Shao J, Wu J, Zhang Q, Wang J, Xiao D, Huang F. | 02/13/2016 |
| Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR-215 targeting protein tyrosine phosphatase, receptor type T (PTPRT). | Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.
Liu F, You X, Chi X, Wang T, Ye L, Niu J, Zhang X. | 05/3/2014 |
| tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3, a potent oncogenic transcription factor and PTPRT substrate | Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.
Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR., Free PMC Article | 03/29/2014 |
| The catalytic domain point mutants show a decreased thermal and thermodynamic stability and decreased activation energy relative to phosphatase activity, when compared to wild- type | Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.
Pasquo A, Consalvi V, Knapp S, Alfano I, Ardini M, Stefanini S, Chiaraluce R., Free PMC Article | 07/7/2012 |
| [review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. | Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Scott A, Wang Z., Free PMC Article | 03/31/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88). | Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, Wang Z., Free PMC Article | 05/10/2010 |
| brain-specific PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase Fyn. | Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.
Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Lee SC, Ryu SE, Yu DY, Chung BH, Kim E, Myung PK, Lee JR., Free PMC Article | 01/21/2010 |
| Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article | 12/2/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH., Free PMC Article | 04/29/2009 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHuman variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
Julià A, Ballina J, Cañete JD, Balsa A, Tornero-Molina J, Naranjo A, Alperi-López M, Erra A, Pascual-Salcedo D, Barceló P, Camps J, Marsal S. | 08/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | Mutational analysis of PTPRT phosphatase domains in common human cancers.
Lee JW, Jeong EG, Lee SH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH, Lee JW, Jeong EG, Lee SH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. | 03/13/2008 |
| STAT3 is a substrate of receptor protein tyrosine phosphatase T | Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ., Free PMC Article | 01/21/2010 |
| alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers | Mutational analysis of PTPRT phosphatase domains in common human cancers.
Lee JW, Jeong EG, Lee SH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH, Lee JW, Jeong EG, Lee SH, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH. | 01/21/2010 |