| Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers. | Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.
Wang Y, Ma L, Jia S, Liu D, Gu H, Wei X, Ma W, Luo W, Bai Y, Wang W, Yuan Z., Free PMC Article | 09/3/2022 |
| Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash. | Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.
Min F, Fan C, Zeng Y, He N, Zeng T, Qin B, Shi Y. | 06/25/2022 |
| Coro1A has a role in platelet biology with impact on spreading, aggregation and thrombosis | The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
Stocker TJ, Pircher J, Skenderi A, Ehrlich A, Eberle C, Megens RTA, Petzold T, Zhang Z, Walzog B, Müller-Taubenberger A, Weber C, Massberg S, Ishikawa-Ankerhold H, Schulz C. | 02/2/2019 |
| Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation. | HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.
Chen L, Gu L, Gu Y, Wang H, Deng M, Stamataki Z, Oo YH, Huang Y., Free PMC Article | 05/5/2018 |
| Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW] | Emergent Role of Coronin-1a in Neuronal Signaling.
Martorella M, Barford K, Winkler B, Deppmann CD., Free PMC Article | 11/4/2017 |
| It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism. | Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.
Castro-Castro A, Muriel O, Del Pozo MA, Bustelo XR., Free PMC Article | 06/24/2017 |
| Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens. | Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
Yee CS, Massaad MJ, Bainter W, Ohsumi TK, Föger N, Chan AC, Akarsu NA, Aytekin C, Ayvaz DÇ, Tezcan I, Sanal Ö, Geha RS, Chou J., Free PMC Article | 08/13/2016 |
| These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. | Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation.
Kim GY, Kim H, Lim HJ, Park HY. | 04/2/2016 |
| Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. | Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
Siegmund K, Thuille N, Posch N, Fresser F, Baier G., Free PMC Article | 09/26/2015 |
| mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres | Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.
Stray-Pedersen A, Jouanguy E, Crequer A, Bertuch AA, Brown BS, Jhangiani SN, Muzny DM, Gambin T, Sorte H, Sasa G, Metry D, Campbell J, Sockrider MM, Dishop MK, Scollard DM, Gibbs RA, Mace EM, Orange JS, Lupski JR, Casanova JL, Noroski LM., Free PMC Article | 06/20/2015 |
| Coronin 1 trimerization is essential to promote mycobacterial survival within macrophages | Coronin 1 trimerization is essential to protect pathogenic mycobacteria within macrophages from lysosomal delivery.
BoseDasgupta S, Pieters J. | 01/24/2015 |
| Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells. | Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.
Mondol AS, Tonks NK, Kamata T. | 01/10/2015 |
| Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. | The expanding spectrum of human coronin 1A deficiency.
Moshous D, de Villartay JP. | 12/20/2014 |
| Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling. | Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.
Ojeda V, Castro-Castro A, Bustelo XR., Free PMC Article | 10/18/2014 |
| show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator | Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.
Mace EM, Orange JS., Free PMC Article | 07/5/2014 |
| These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis. | Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis.
Rouwette M, Noben JP, Van Horssen J, Van Wijmeersch B, Hupperts R, Jongen PJ, Verbeek MM, De Deyn PP, Stinissen P, Somers V. | 10/26/2013 |
| Our findings define a new clinical entity of a primary immunodeficiency with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorphic Coronin-1A mutation. | Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.
Moshous D, Martin E, Carpentier W, Lim A, Callebaut I, Canioni D, Hauck F, Majewski J, Schwartzentruber J, Nitschke P, Sirvent N, Frange P, Picard C, Blanche S, Revy P, Fischer A, Latour S, Jabado N, de Villartay JP. | 08/3/2013 |
| PU.1 and CEBPA are direct transcriptional regulators of CORO1A in acute promyelocytic leukemia and acute myeloid leukemia. | The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients.
Federzoni EA, Humbert M, Valk PJ, Behre G, Leibundgut EO, Torbett BE, Fey MF, Tschan MP. | 07/27/2013 |
| Constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin. | Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.
Oku T, Nakano M, Kaneko Y, Ando Y, Kenmotsu H, Itoh S, Tsuiji M, Seyama Y, Toyoshima S, Tsuji T., Free PMC Article | 02/16/2013 |
| Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation | Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.
Castro-Castro A, Ojeda V, Barreira M, Sauzeau V, Navarro-Lérida I, Muriel O, Couceiro JR, Pimentel-Muíños FX, Del Pozo MA, Bustelo XR., Free PMC Article | 12/24/2011 |
| Instead of regulating the F-actin cytoskeleton, coronin 1 functions in balancing pro- and antiapoptotic signals by regulating divalent calcium ion fluxes and calcineurin activation downstream of the T cell receptor. | Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation.
Mueller P, Liu X, Pieters J. | 06/18/2011 |
| Circulating neutrophils from CF patients had more coronin-1 expression, associated with a lower apoptosis rate | Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients.
Moriceau S, Kantari C, Mocek J, Davezac N, Gabillet J, Guerrera IC, Brouillard F, Tondelier D, Sermet-Gaudelus I, Danel C, Lenoir G, Daniel S, Edelman A, Witko-Sarsat V. | 01/21/2010 |
| phosphorylation of p57/coronin-1 down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton | Phorbol ester-dependent phosphorylation regulates the association of p57/coronin-1 with the actin cytoskeleton.
Oku T, Kaneko Y, Murofushi K, Seyama Y, Toyoshima S, Tsuji T., Free PMC Article | 01/21/2010 |
| Findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation. | The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG., Free PMC Article | 01/21/2010 |
| These results demonstrate that p57/coronin-1 forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. | Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region.
Oku T, Itoh S, Ishii R, Suzuki K, Nauseef WM, Toyoshima S, Tsuji T., Free PMC Article | 01/21/2010 |