| Role and function of plakophilin 3 in cancer progression and skin disease. | Role and function of plakophilin 3 in cancer progression and skin disease.
Zhang Y, Chen J, Tian J, Zhou Y, Liu Y., Free PMC Article | 02/5/2024 |
| Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells. | Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells.
Schamschula E, Lahnsteiner A, Assenov Y, Hagmann W, Zaborsky N, Wiederstein M, Strobl A, Stanke F, Muley T, Plass C, Tümmler B, Risch A., Free PMC Article | 09/3/2022 |
| Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex. | Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex.
Indra I, Troyanovsky RB, Green KJ, Troyanovsky SM., Free PMC Article | 01/29/2022 |
| A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals. | A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.
Hong JY, Zapata J, Blackburn A, Baumert R, Bae SM, Ji H, Nam HJ, Miller RK, McCrea PD., Free PMC Article | 11/13/2021 |
| 14-3-3sigma (also known as stratifin, encoded by SFN) interacted preferentially with S285-phosphorylated PKP3 to promote its accumulation at tricellular contact sites, leading to stable desmosomes. | 14-3-3 proteins regulate desmosomal adhesion via plakophilins.
Rietscher K, Keil R, Jordan A, Hatzfeld M. | 11/2/2019 |
| PKP3 loss leads to an increase in invasion, tumor formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression. | Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation.
Basu S, Chaudhary N, Shah S, Braggs C, Sawant A, Vaz S, Thorat R, Gupta S, Dalal SN. | 09/28/2019 |
| The result of this study PKP3 as the oncogene candidate and a potential target for the treatment of ovarian cancer. | PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Lim V, Zhu H, Diao S, Hu L, Hu J. | 05/25/2019 |
| Nasopharyngeal carcinoma (NPC) tissues display a significant high miR-149 and low PKP3 expressions indicating that both play an important role in NPC metastasis. Downregulation of miR-149 resulting in the increment of PKP3 expression. Also, N,N'-dinitrosopiperazine (DNP)-mediated PKP3 decrease was eliminated by miR-149 in NPC cells. This suggests that DNP may reduce PKP3 expression through upregulating miR-149. | Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis.
Li Y, Ju K, Wang W, Liu Z, Xie H, Jiang Y, Jiang G, Lu J, Dong Z, Tang F., Free PMC Article | 05/18/2019 |
| plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma | Expression of plakophilin 3 in diffuse malignant pleural mesothelioma.
Mašić S, Brčić L, Krušlin B, Šepac A, Pigac B, Stančić-Rokotov D, Jakopović M, Seiwerth S. | 01/12/2019 |
| PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins. | Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.
Gurjar M, Raychaudhuri K, Mahadik S, Reddy D, Atak A, Shetty T, Rao K, Karkhanis MS, Gosavi P, Sehgal L, Gupta S, Dalal SN. | 12/30/2017 |
| Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death. | Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.
Gupta A, Montepiedra G, Gupte A, Zeldow B, Jubulis J, Detrick B, Violari A, Madhi S, Bobat R, Cotton M, Mitchell C, Spector S, IMPAACT NWCS113 and P1041 Study Team., Free PMC Article | 07/16/2016 |
| Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2). | Desmocollin-2 alone forms functional desmosomal plaques, with the plaque formation requiring the juxtamembrane region and plakophilins.
Fujiwara M, Nagatomo A, Tsuda M, Obata S, Sakuma T, Yamamoto T, Suzuki ST. | 07/2/2016 |
| The results suggest that MMP7 over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation. | MMP7 is required to mediate cell invasion and tumor formation upon Plakophilin3 loss.
Basu S, Thorat R, Dalal SN., Free PMC Article | 01/16/2016 |
| reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3. | c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress.
Neuber S, Jäger S, Meyer M, Wischmann V, Koch PJ, Moll R, Schmidt A. | 11/21/2015 |
| These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1. | Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.
Todorovic V, Koetsier JL, Godsel LM, Green KJ., Free PMC Article | 07/25/2015 |
| cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression. | Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Fischer-Kešo R, Breuninger S, Hofmann S, Henn M, Röhrig T, Ströbel P, Stoecklin G, Hofmann I., Free PMC Article | 01/17/2015 |
| Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3. | Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3.
Cirillo N, AlShwaimi E, McCullough M, Prime SS. | 10/4/2014 |
| The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b. | An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b.
Mühmer M, Ditthardt D, Jäkel J, Wischmann V, Moll R, Schmidt A. | 09/13/2014 |
| stratifin plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells. | Stratifin (14-3-3 σ) limits plakophilin-3 exchange with the desmosomal plaque.
Roberts BJ, Reddy R, Wahl JK 3rd., Free PMC Article | 05/24/2014 |
| In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased | Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers.
Demirag GG, Sullu Y, Yucel I. | 06/15/2013 |
| Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis. | Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.
Khapare N, Kundu ST, Sehgal L, Sawant M, Priya R, Gosavi P, Gupta N, Alam H, Karkhanis M, Naik N, Vaidya MM, Dalal SN., Free PMC Article | 11/17/2012 |
| These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. | Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis.
Horne DJ, Randhawa AK, Chau TT, Bang ND, Yen NT, Farrar JJ, Dunstan SJ, Hawn TR., Free PMC Article | 03/17/2012 |
| plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation | E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.
Gosavi P, Kundu ST, Khapare N, Sehgal L, Karkhanis MS, Dalal SN., Free PMC Article | 05/28/2011 |
| loss of PKP3 expression during gastric adenocarcinoma progression may indicate an invasive phenotype. | Expression of plakophilins (PKP1, PKP2, and PKP3) in gastric cancers.
Demirag GG, Sullu Y, Gurgenyatagi D, Okumus NO, Yucel I., Free PMC Article | 05/21/2011 |
| both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype | Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression.
Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I., Free PMC Article | 01/1/2011 |