| Tumor-derived KLK8 predicts inferior survival and promotes an immune-suppressive tumor microenvironment in lung squamous cell carcinoma. | Tumor-derived KLK8 predicts inferior survival and promotes an immune-suppressive tumor microenvironment in lung squamous cell carcinoma.
Tian H, Wei R, Xiao C, Fan T, Che Y, Liu T, Zheng B, Li C, He J., Free PMC Article | 02/7/2024 |
| circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression. | circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression.
Luo Q, Li J, Miao H, Su S, Chen Y, Xu C, Zhao C, Huang J, Ling K, Lin C, Yan H, Zhang S. | 12/6/2023 |
| Kallikrein 8: A key sheddase to strengthen and stabilize neural plasticity. | Kallikrein 8: A key sheddase to strengthen and stabilize neural plasticity.
Shiosaka S. | 09/10/2022 |
| DNA methylation of the KLK8 gene in depression symptomatology. | DNA methylation of the KLK8 gene in depression symptomatology.
Starnawska A, Bukowski L, Chernomorchenko A, Elfving B, Müller HK, van den Oord E, Aberg K, Guintivano J, Grove J, Mors O, Børglum AD, Nielsen AL, Qvist P, Staunstrup NH., Free PMC Article | 02/19/2022 |
| KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1. | KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1.
Hua Q, Sun Z, Liu Y, Shen X, Zhao W, Zhu X, Xu P., Free PMC Article | 02/5/2022 |
| The association of serum Kallikrein-8 with cognitive function in vascular dementia. | The association of serum Kallikrein-8 with cognitive function in vascular dementia.
Li J, Li SL, Song YH, Li ZP, Wang N, Zhang GH, Zhu CL. | 01/8/2022 |
| Extracellular acidityinduced expression of Kallikreinrelated peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells. | Extracellular acidity‑induced expression of Kallikrein‑related peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells.
Lim SC, Kee KH, Lee MJ, Hong R, Han SI. | 02/6/2021 |
| Blood KLK8 was a similarly strong discriminator for mild cognitive impairment but slightly weaker for Alzheimer's disease | CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer's disease.
Teuber-Hanselmann S, Rekowski J, Vogelgsang J, von Arnim C, Reetz K, Stang A, Jöckel KH, Wiltfang J, Esselmann H, Otto M, Tumani H, Herring A, Keyvani K., Free PMC Article | 07/11/2020 |
| Study findings provide a comprehensive picture of the molecular mechanisms underlying the enzyme activity of recombinant human KLK8. Enzyme kinetics with optimized substrates showed stimulation by Ca2+ and inhibition by Zn2+, which are physiological regulators. Crystal structures of KLK8 with a ligand-free active site and with the inhibitor leupeptin explain the subsite specificity and display Ca2+ bound to the 75-loop. | Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P., Free PMC Article | 11/2/2019 |
| KLK8 levels are higher in female brain and female sex hormone increases KLK8 in neuronal/glial cells. Hippocampal KLK8 protein levels were drastically increased in women patients. | Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease.
Keyvani K, Münster Y, Kurapati NK, Rubach S, Schönborn A, Kocakavuk E, Karout M, Hammesfahr P, Wang YC, Hermann DM, Teuber-Hanselmann S, Herring A., Free PMC Article | 06/1/2019 |
| Telbivudine treatment resulted in increased levels of serum KLK8 protein. Furthermore, eGFR increase was associated with body height-adjusted, post-treatment KLK8 levels | Increase of Serum Kallikrein-8 Level After Long-term Telbivudine Treatment.
Wang HE, Lin CL, Pan TL, Yeh CT., Free PMC Article | 10/13/2018 |
| mRNA expression levels of KLK6 and KLK8 in advanced serous ovarian cancer | Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Ahmed N, Dorn J, Napieralski R, Drecoll E, Kotzsch M, Goettig P, Zein E, Avril S, Kiechle M, Diamandis EP, Schmitt M, Magdolen V., Free PMC Article | 07/8/2017 |
| elevated KLK8 expression was correlated with the progression of colorectal cancer. | Elevated expression of KLK8 predicts poor prognosis in colorectal cancer.
Liu X, Quan B, Tian Z, Xi H, Jia G, Wang H, Zhang L, Liu R, Ma C, Han F, Li H, Yuan F. | 04/1/2017 |
| KLK8 mRNA expression is associated with aggressive tumor characteristics and it can serve as a novel independent biomarker of unfavorable prognosis for BC patients. | Clinical relevance of the deregulated kallikrein-related peptidase 8 mRNA expression in breast cancer: a novel independent indicator of disease-free survival.
Michaelidou K, Ardavanis A, Scorilas A. | 03/26/2016 |
| Occurring independently of cyclophilins and of furin that mediate human papillomavirus 16 L2 exposure, KLK8-mediated cleavage of L1 likely facilitated access to L2, located in the capsid lumen, and potentially uncoating. | Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells.
Cerqueira C, Samperio Ventayol P, Vogeley C, Schelhaas M., Free PMC Article | 09/5/2015 |
| It dissects a schizophrenic susceptibility gene, NRG1. | [Neuropsin signaling as a novel therapeutic target of schizophrenia].
Tawara-Hirata Y. | 06/7/2014 |
| KLK8 and KLK14 can signal differentially via the PARs to affect tissue function | Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14.
Ramachandran R, Eissa A, Mihara K, Oikonomopoulou K, Saifeddine M, Renaux B, Diamandis E, Hollenberg MD. | 09/1/2012 |
| KLK8 as a new active serine protease in human stratum corneum and sweat | Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade.
Eissa A, Amodeo V, Smith CR, Diamandis EP., Free PMC Article | 02/5/2011 |
| The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8. | Human kallikrein 8 expression in salivary gland tumors.
Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP., Free PMC Article | 10/23/2010 |
| The KLK8-T4 alternative splice variant, alone or in combination, may be a new independent marker of unfavorable prognosis in lung cancer. | Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer.
Planque C, Choi YH, Guyetant S, Heuzé-Vourc'h N, Briollais L, Courty Y. | 07/5/2010 |
| Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively. | Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.
Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis EP. | 01/21/2010 |
| The processed end-point enzymes are the same for both type I and type II kallikrein 8, suggesting that the emergence of type II kallikrein 8 in the human brain likely leads to functional modifications of kallikrein 8. | Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory.
Lu ZX, Huang Q, Su B. | 01/21/2010 |
| kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression | Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.
Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, Liu Y, Ravosa MJ, Frazier S, Stack MS., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesBlood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Klein RJ, Halldén C, Cronin AM, Ploner A, Wiklund F, Bjartell AS, Stattin P, Xu J, Scardino PT, Offit K, Vickers AJ, Grönberg H, Lilja H. Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.
Izumi A, Iijima Y, Noguchi H, Numakawa T, Okada T, Hori H, Kato T, Tatsumi M, Kosuga A, Kamijima K, Asada T, Arima K, Saitoh O, Shiosaka S, Kunugi H. | 04/3/2008 |
| analysis of how a mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory | A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.
Lu ZX, Peng J, Su B. | 01/21/2010 |