| High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model. | High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
Dash P, Ghatak S, Topi G, Satapathy SR, Ek F, Hellman K, Olsson R, Mehdawi LM, Sjölander A., Free PMC Article | 03/12/2022 |
| Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. | Molecular basis for lipid recognition by the prostaglandin D(2) receptor CRTH2.
Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C., Free PMC Article | 12/18/2021 |
| YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2. | YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.
Bie Q, Li X, Liu S, Yang X, Qian Z, Zhao R, Zhang X, Zhang B. | 01/16/2021 |
| A Granulocytic Signature Identifies COVID-19 and Its Severity. | A Granulocytic Signature Identifies COVID-19 and Its Severity.
Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL., Free PMC Article | 12/26/2020 |
| Knockdown of the DP2 receptor in cultured human hair follicles inhibits the anagen-catagen transition. outer root sheath and dermal papilla cells express higher levels of DP2 receptor compared with the matched nonbalding cells of male pattern baldness patients. | Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.
Kang YR, Bak SS, Kim MK, Joo HW, Mali NM, Shin MJ, Kim MK, Kim JC, Oh JW, Sung YK. | 06/6/2020 |
| We did not find differences in PTGDR2 in affected and unaffected individuals. | Prostaglandins in androgenetic alopecia in 12 men and four female.
Villarreal-Villarreal CD, Sinclair RD, Martínez-Jacobo L, Garza-Rodríguez V, Rodríguez-León SA, Lamadrid-Zertuche AC, Rodríguez-Gutierrez R, Ortiz-Lopez R, Rojas-Martinez A, Ocampo-Candiani J. | 01/18/2020 |
| the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization. | PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.
Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S. | 09/21/2019 |
| These results demonstrate the critical role of CRTH2-mediated Th2 response in Pulmonary arterial hypertension pathogenesis. | Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice.
Chen G, Zuo S, Tang J, Zuo C, Jia D, Liu Q, Liu G, Zhu Q, Wang Y, Zhang J, Shen Y, Chen D, Yuan P, Qin Z, Ruan C, Ye J, Wang XJ, Zhou Y, Gao P, Zhang P, Liu J, Jing ZC, Lu A, Yu Y., Free PMC Article | 06/22/2019 |
| The structures, together with docking and ligand-binding data, reveal a semi-occluded pocket covered by a well-structured amino terminus and different binding modes of chemically diverse CRTH2 antagonists | Structures of the Human PGD(2) Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C., Free PMC Article | 04/20/2019 |
| Prostaglandin D2 (PGD2) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as TH2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma | The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation.
Domingo C, Palomares O, Sandham DA, Erpenbeck VJ, Altman P., Free PMC Article | 03/2/2019 |
| The data indicate that expression of CRTh2 is regulated through the competitive action of GATA3 and NFAT1. | Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism.
MacLean Scott E, Solomon LA, Davidson C, Storie J, Palikhe NS, Cameron L., Free PMC Article | 12/29/2018 |
| The frequencies of the AA genotype of the CRTH2 rs545659 SNP and the CC genotype and the C allele of the CRTH2 rs634681 SNP were higher in patients with severe Hashimoto disease than in patients with mild Hashimoto disease. | Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases.
Omori N, Watanabe M, Inoue N, Taniguchi J, Hidaka Y, Iwatani Y. | 12/22/2018 |
| prediction of 3D structures for the DP prostaglandin GPCR, based on the GEnSeMBLE complete sampling with hierarchical scoring (CS-HS) methodology | The 3D Structure of Human DP Prostaglandin G-Protein-Coupled Receptor Bound to Cyclopentanoindole Antagonist, Predicted Using the DuplexBiHelix Modification of the GEnSeMBLE Method.
Shankar V, Goddard WA 3rd, Kim SK, Abrol R, Liu F. | 04/28/2018 |
| Report CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa. | Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.
Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD. | 01/20/2018 |
| CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy. | Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.
Calbet M, Andrés M, Armengol C, Bravo M, Eichhorn P, López R, García-González V, Roberts R, Miralpeix M. | 12/30/2017 |
| CRTH2 plays a pro-inflammatory role in TNBS-induced colitis and Crohn's disease. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist. Serum levels of PGD2 and Delta(12)-PGJ2 were increased in Crohn's disease patients as compared with control individuals. | Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.
Radnai B, Sturm EM, Stančić A, Jandl K, Labocha S, Ferreirós N, Grill M, Hasenoehrl C, Gorkiewicz G, Marsche G, Heinemann Á, Högenauer C, Schicho R., Free PMC Article | 06/10/2017 |
| this study shows that allergic rhinitis patients increased the amounts of VIP and PGD2 in their nasal secretions in the early phase reaction, however CRTH2 gene expression from leukocytes recovered in their nasal secretions was upregulated only during the late phase reaction | Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis.
El-Shazly AE, Roncarati P, Lejeune M, Lefebvre PP, Delvenne P. | 06/3/2017 |
| the CRTH2 expression on thyroid-infiltrating lymphocytes as well as on lymphocytes from peripheral blood was increased in Hashimoto's thyroiditis as compared to controls. | CXCR3, CCR5, and CRTH2 Chemokine Receptor Expression in Lymphocytes Infiltrating Thyroid Nodules with Coincident Hashimoto's Thyroiditis Obtained by Fine Needle Aspiration Biopsy.
Jiskra J, Antošová M, Krátký J, Vítková H, Límanová Z, Marečková H, Potluková E., Free PMC Article | 03/11/2017 |
| smaller proportion of group 2 innate lymphoid cells isolated from nondiseased human lung expressed CRTH2 | The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung.
Wojno ED, Monticelli LA, Tran SV, Alenghat T, Osborne LC, Thome JJ, Willis C, Budelsky A, Farber DL, Artis D., Free PMC Article | 08/20/2016 |
| Altered expression of chemoattractant CRTH2 on blood basophils and eosinophils in patients with chronic spontaneous urticaria | Altered expression of chemoattractant receptor-homologous molecule expressed on T(H)2 cells on blood basophils and eosinophils in patients with chronic spontaneous urticaria.
Oliver ET, Sterba PM, Devine K, Vonakis BM, Saini SS. | 05/28/2016 |
| Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. | DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.
Kalmár A, Péterfia B, Hollósi P, Galamb O, Spisák S, Wichmann B, Bodor A, Tóth K, Patai ÁV, Valcz G, Nagy ZB, Kubák V, Tulassay Z, Kovalszky I, Molnár B., Free PMC Article | 04/23/2016 |
| Data indicate that in ulcerative colitis, DP2 receptor showed higher expression in neutrophils but lower in monocytes, and CRTH2 receptor was decreased in eosinophils, NK, and CD3(+) T cells but not in monocytes and CD3(+)/CD4(+) T cells. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis.
Sturm EM, Radnai B, Jandl K, Stančić A, Parzmair GP, Högenauer C, Kump P, Wenzl H, Petritsch W, Pieber TR, Schuligoi R, Marsche G, Ferreirós N, Heinemann A, Schicho R., Free PMC Article | 10/4/2014 |
| Low DP2 prostanoid receptor is associated with gastric cancer progression. | The role of type D prostanoid receptors and PPARγ in gastric cancer progression.
Fukuoka T, Yashiro M, Morisaki T, Kinoshita H, Hasegawa T, Kasashima H, Masuda G, Sakurai K, Toyokawa T, Tanaka H, Kubo N, Muguruma K, Ohira M, Hirakawa K. | 08/23/2014 |
| CRTh2 rs533116 was associated with allergic asthma in White people | The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2.
Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L. | 06/22/2013 |
| CRTH2 is not expressed on human amniocytes or myocytes and plays no role in the mechanism of 15dPGJ2-mediated inhibition of NF-kappaB | Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes.
Sykes L, Lee Y, Khanjani S, Macintyre DA, Yap XJ, Ponnampalam S, Teoh TG, Bennett PR., Free PMC Article | 05/25/2013 |