| Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis. | Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.
Liimatta J, Curschellas E, Altinkilic EM, Naamneh Elzenaty R, Augsburger P, du Toit T, Voegel CD, Breault DT, Flück CE, Pignatti E., Free PMC Article | 02/20/2024 |
| Macrophage Gpx4 deficiency aggravates foam cell formation by regulating the expression of scavenger receptors, ABCA1, and ABCG1. | Macrophage Gpx4 deficiency aggravates foam cell formation by regulating the expression of scavenger receptors, ABCA1, and ABCG1.
Zhou J, Wu S, Chen X, Hou L, Zhong Q, Luo W, Dai C, Dai X. | 08/9/2023 |
| Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury. | Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury.
Xu H, Zheng LX, Chen XS, Pang QY, Yan YN, Liu R, Guo HM, Ren ZY, Yang Y, Gu ZY, Gao C, Gao Y, Luo CL, Zhao Y, Wang Y, Wang T, Tao LY., Free PMC Article | 05/7/2023 |
| Interferon-gamma decreases ATP-binding cassette subfamily G member 1-mediated cholesterol efflux through small ubiquitin-like modifier/ubiquitin-dependent liver X receptor-alpha degradation in macrophages. | Interferon-γ decreases ATP-binding cassette subfamily G member 1-mediated cholesterol efflux through small ubiquitin-like modifier/ubiquitin-dependent liver X receptor-α degradation in macrophages.
Dong M, Zhang Y, Xu C, Wang C, Liu M, Zhang Z, Wu H, Yuan Z, Zhou J. | 01/22/2022 |
| ATP-binding cassette g1 regulates osteogenesis via Wnt/beta-catenin and AMPK signaling pathways. | ATP-binding cassette g1 regulates osteogenesis via Wnt/β-catenin and AMPK signaling pathways.
Zhou L, Sun S, Zhang T, Yu Y, Xu L, Li H, Wang M, Hong Y. | 05/22/2021 |
| ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity. | ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity.
Dunn PJ, Salm EJ, Tomita S., Free PMC Article | 12/19/2020 |
| Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells. | Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Yin H, Jiang Z, Feng X, Ji Z, Jin W., Free PMC Article | 12/5/2020 |
| that the deficiency of alveolar macrophage ABCG1 promotes pulmonary granulomatous inflammation and that this is augmented by additional deletion of ABCA1 | Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation.
McPeek M, Malur A, Tokarz DA, Lertpiriyapong K, Gowdy KM, Murray G, Wingard CJ, Fessler MB, Barna BP, Thomassen MJ., Free PMC Article | 03/28/2020 |
| Here, the authors study the contribution of lipid efflux in the retinal pigment epithelium by generating a mouse model lacking ABCA1 and its partner ABCG1 specifically in this layer. Mutant mice show lipid accumulation in the retinal pigment epithelium, reduced retinal pigment epithelium and retinal function, retinal inflammation and retinal pigment epithelium/photoreceptor degeneration. | Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde-Visser S, Samardzija M, Meneau I, Barben M, Karademir D, Pauzuolyte V, Boye SL, Blaser F, Ullmer C, Dunaief JL, Hornemann T, Rohrer L, den Hollander A, von Eckardstein A, Fingerle J, Maugeais C, Grimm C., Free PMC Article | 03/21/2020 |
| ABCG1-overexpressing EPCs showed increased migration and tube formation and differentiation via the Lck/Yes-related novel protein tyrosine kinase /Akt/endothelial NO synthase pathway. | Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.
Shi Y, Lv X, Liu Y, Li B, Liu M, Yan M, Liu Y, Li Q, Zhang X, He S, Zhu M, He J, Zhu Y, Zhu Y, Ai D. | 05/18/2019 |
| Stably expressed GFP-tagged ABCG1 closely mimics the distribution of endogenous ABCG1 in pancreatic insulin-secreting cells and accumulates in the trans-Golgi network (TGN), endosomal recycling compartment (ERC) and on the cell surface but not on insulin granules, early or late endosomes. Notably, ABCG1 is short-lived, and proteasomal and lysosomal inhibitors both decrease its degradation. | Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function.
Harris MT, Hussain SS, Inouye CM, Castle AM, Castle JD., Free PMC Article | 03/2/2019 |
| The TLR4 expression increased significantly in the arterial walls after receiving HFD treatment, while that of the co-localizing PPARgamma and ABCG1 markedly decreased. TLR4 deficiency reversed the HFD-induced attenuation of PPARgamma and ABCG1. | TLR4 mediates high-fat diet induced physiological changes in mice via attenuating PPARγ/ABCG1 signaling pathway.
Cao XJ, Zhang MJ, Zhang LL, Yu K, Xiang Y, Ding X, Fan J, Li JC, Wang QS. | 02/23/2019 |
| ABCG1 knockout mice exhibited an altered expression of multiple genes related to many aspects of atherosclerosis, which might affect the further studies to insight into the effect of ABCG1 on atherosclerosis with this animal model. | Analysis of differential gene expression by RNA-seq data in ABCG1 knockout mice.
Shen SQ, Yan XW, Li PT, Ji XH. | 02/9/2019 |
| HSP70 promotes the progression of atherosclerosis in apoE-/- mice by suppressing the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. | Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.
Zhao ZW, Zhang M, Chen LY, Gong D, Xia XD, Yu XH, Wang SQ, Ou X, Dai XY, Zheng XL, Zhang DW, Tang CK. | 12/22/2018 |
| TMP upregulated the protein stability of ABCA1 without affecting ABCG1. Accordingly, TMP regulated the expression of SR-A, CD36, ABCA1 and ABCG1 in aortas of ApoE-/- mice, which resembled the findings observed in macrophages. | Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors.
Duan J, Xiang D, Luo H, Wang G, Ye Y, Yu C, Li X. | 07/7/2018 |
| ABCG1 regulates pulmonary surfactant metabolism | ABCG1 regulates pulmonary surfactant metabolism in mice and men.
de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ., Free PMC Article | 12/23/2017 |
| ABCG1 regulates T cell differentiation into Tregs, highlighting a pathway by which cholesterol accumulation can influence T cell homeostasis in atherosclerosis | Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.
Cheng HY, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M, Hedrick CC., Free PMC Article | 09/30/2017 |
| Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR-ABCA1/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL-C levels observed in patients receiving both medications | Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes.
Mostafa AM, Hamdy NM, Abdel-Rahman SZ, El-Mesallamy HO. | 09/2/2017 |
| ABCG1 may play a protective role in early-stage atherosclerosis by reducing endothelial activation induced by oscillatory shear stress via suppressing the inflammatory response. | Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis.
Xue S, Wang J, Zhang X, Shi Y, Li B, Bao Q, Pang W, Ai D, Zhu Y, He J. | 06/24/2017 |
| Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow. | Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
Westerterp M, Tsuchiya K, Tattersall IW, Fotakis P, Bochem AE, Molusky MM, Ntonga V, Abramowicz S, Parks JS, Welch CL, Kitajewski J, Accili D, Tall AR., Free PMC Article | 06/24/2017 |
| ABCG1, irrespective of either a leucine or proline at position 550, is an intracellular protein that localizes to vesicles of the endosomal pathway where it functions to mobilize sterols away from the endoplasmic reticulum and out of the cell. | Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.
Tarling EJ, Edwards PA., Free PMC Article | 06/24/2017 |
| our study suggests that MEK1/2 inhibitors activate macrophage ABCG1 expression/RCT, and inhibit foam cell formation and lesion development by multiple mechanisms, supporting the concept that ERK1/2 inhibition is anti-atherogenic | MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.
Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y, Han J. | 06/3/2017 |
| miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction and NF-kappaB activation by LPS. This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X receptor agonists. | MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Näär AM, Fessler MB., Free PMC Article | 05/20/2017 |
| ABCG1 expression was down-regulated by TLR4, which induces inflammation and lipid accumulation in vascular smooth muscle cells via PPARgamma/LXRalpha signaling. | The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells.
Cao X, Zhang L, Chen C, Wang Q, Guo L, Ma Q, Deng P, Zhu G, Li B, Pi Y, Long C, Zhang L, Yu Z, Zhou Z, Li J. | 05/20/2017 |
| Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways. | VISFATIN PROMOTES FOAM CELL FORMATION BY DYSREGULATING CD36, SRA, ABCA1, AND ABCG1 EXPRESSION IN RAW264.7 MACROPHAGES.
Lin YT, Jian DY, Kwok CF, Ho LT, Juan CC. | 12/17/2016 |