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    Gpnmb glycoprotein nmb [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113955, updated on 6-May-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Altered expression of glycoprotein nonmetastatic melanoma protein B in the distal sciatic nerve following injury.

    Altered expression of glycoprotein non‑metastatic melanoma protein B in the distal sciatic nerve following injury.
    Zheng Y, Huang C, Yang X, Zhang Z., Free PMC Article

    objective of this study is to investigate the potential regenerative effect of OA embedded and delivered via a cross-linked gelatin hydrogel within a volumetric tibialis anterior muscle defect in a rat model

    Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model.
    Ma J, Baker AR, Calabro A, Derwin KA., Free PMC Article

    This is the first experimental study to show that GPNMB adversely influences myocardial remodeling.

    Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
    Järve A, Mühlstedt S, Qadri F, Nickl B, Schulz H, Hübner N, Özcelik C, Bader M.

    A simultaneous increase in osteoactivin occurred with factors involved in tissue repair (MMPs and HSP72), in tissue regeneration after repetitive overuse.

    Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
    Frara N, Abdelmagid SM, Tytell M, Amin M, Popoff SN, Safadi FF, Barbe MF., Free PMC Article

    The GPNMB is a promising biomarker and therapeutic target for the development and progression of Nonalcoholic fatty liver disease in obesity.

    Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
    Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, Nunoue T, Hida K, Wada N, Yasunaka T, Ikeda F, Takaki A, Yamamoto K, Kiyonari H, Makino H, Wada J., Free PMC Article

    Glycoprotein nonmetastatic melanoma protein B plays an important role in angiogenesis during hyperoxia injury

    Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.
    Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, Liu L., Free PMC Article

    translocalization of carboxy-terminal fragment of osteoactivin to the nucleus and the endoplasmic reticulum

    An intracellular fragment of osteoactivin formed by ectodomain shedding translocated to the nucleoplasm and bound to RNA binding proteins.
    Utsunomiya K, Owaki K, Okumura Y, Yano M, Oto T, Suzuki E, Tamura S, Abe T, Kohno S, Ohno A, Hirasaka K, Teshima-Kondoh S, Nikawa T.

    Osteoactivin is expressed in the kidney after acute cyclosporine A toxicity, and mainly expresses in the tubular epithelial cells and renal interstitium

    [Expression and mechanism of osteoactivin in the kidney of SD rats after acute cyclosporine A toxicity].
    Ye M, Xie X, Peng L, Tan L, Lan G, Yu S.

    OA transcription is differentially regulated by Dlx3, Dlx5, and Msx2 during osteoblast differentiation.

    Homeodomain transcription factors regulate BMP-2-induced osteoactivin transcription in osteoblasts.
    Singh M, Del Carpio-Cano FE, Monroy MA, Popoff SN, Safadi FF.

    HGFIN may be a biomarker of progressive kidney disease

    Hematopoietic growth factor inducible neurokinin-1 (Gpnmb/Osteoactivin) is a biomarker of progressive renal injury across species.
    Patel-Chamberlin M, Wang Y, Satirapoj B, Phillips LM, Nast CC, Dai T, Watkins RA, Wu X, Natarajan R, Leng A, Ulanday K, Hirschberg RR, Lapage J, Nam EJ, Haq T, Adler SG.

    Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis.

    The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair.
    Li B, Castano AP, Hudson TE, Nowlin BT, Lin SL, Bonventre JV, Swanson KD, Duffield JS., Free PMC Article

    Bioinformatic structural analysis predicted that OA has three major structural domains: two helical structures on its termini and beta sheets as a sandwich-like structure in the middle.

    Osteoactivin bioinformatic analysis: prediction of novel functions, structural features, and modes of action.
    Selim AA.

    Early-phase upregulation of osteoactivin expression in the tubular epithelium in response to renal injury may play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats.

    Early induction of osteoactivin expression in rat renal tubular epithelial cells after unilateral ureteral obstruction.
    Nakamura A, Ishii A, Ohata C, Komurasaki T.

    These results indicate that transgenic osteoactivin expression attenuates the development of hepatic fibrosis in association with the suppression of specific genes involved in its pathogenesis.

    Transgenic expression of osteoactivin in the liver attenuates hepatic fibrosis in rats.
    Abe H, Uto H, Takami Y, Takahama Y, Hasuike S, Kodama M, Nagata K, Moriuchi A, Numata M, Ido A, Tsubouchi H.

    Bone morphogenetic protein-2 (BMP-2)regulates osteoactivin (OA) expression through the Smad1 signaling pathway. OA protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function.

    Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function.
    Abdelmagid SM, Barbe MF, Arango-Hisijara I, Owen TA, Popoff SN, Safadi FF.

    Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury.

    Expression of osteoactivin in rat and human liver and isolated rat liver cells.
    Haralanova-Ilieva B, Ramadori G, Armbrust T.

    results indicate that osteoactivin is a novel factor involved in the progression of hepatocellular carcinoma via stimulation of tumor invasiveness and metastatic potential

    Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells.
    Onaga M, Ido A, Hasuike S, Uto H, Moriuchi A, Nagata K, Hori T, Hayash K, Tsubouchi H.

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