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    Flt4 Fms related receptor tyrosine kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114110, updated on 10-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.

    miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.
    He H, Wang J, Zhang Y, Wang Y, Liu Y, Li X, Zhang Y, Yang J, Hao X, Wang H, Liu H.

    06/8/2024
    VEGF-C/VEGFR3 signaling activates lymphatic endothelium in cervical lymph nodes after ischemic stroke.

    Brain-to-cervical lymph node signaling after stroke.
    Esposito E, Ahn BJ, Shi J, Nakamura Y, Park JH, Mandeville ET, Yu Z, Chan SJ, Desai R, Hayakawa A, Ji X, Lo EH, Hayakawa K., Free PMC Article

    03/7/2020
    The findings of this study suggest an important role for VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain development, and ongoing functions with niche neurogenesis, glial and ependymal function in the maturing postnatal brain.

    Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.
    Ward MC, Cunningham AM.

    05/14/2016
    Expression of VEGFR-3 is enhanced in various cell types of the infarcted heart.

    Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart.
    Zhao T, Zhao W, Chen Y, Liu L, Ahokas RA, Sun Y., Free PMC Article

    04/26/2014
    lymph node-specific antibody-mediated inhibition of VEGFR-3 activation in response to VEGF-C draining to the nodes from metastatic MT-450 tumors inhibited the outgrowth but not initiation of metastases in these nodes.

    Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.
    Quagliata L, Klusmeier S, Cremers N, Pytowski B, Harvey A, Pettis RJ, Thiele W, Sleeman JP.

    04/12/2014
    vasculature-associated VEGFR-3-expressing cells in the ischemic core may represent a heterogeneous population of cells with functional diversity, rather than a uniform cell type

    Induction of vascular endothelial growth factor receptor-3 expression in perivascular cells of the ischemic core following focal cerebral ischemia in rats.
    Shin YJ, Park JM, Cho JM, Cha JH, Kim SY, Lee MY.

    06/29/2013
    VEGF-C/VEGFR-3 signaling modulated innate and adaptive immune responses in the development of obliterative bronchiolitis in rat tracheal allografts.

    Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.
    Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, Nykänen AI, Lemström KB.

    03/23/2013
    VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during experimental autoimmune encephalomyelitis.

    Upregulation of vascular endothelial growth factor receptor-3 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis.
    Park JM, Shin YJ, Cho JM, Choi JY, Jeun SS, Cha JH, Lee MY., Free PMC Article

    03/9/2013
    The present study presents, to our knowledge, the first detailed mapping of VEGFR-3 mRNA expression in adult rat brain and spinal cord

    Distribution of vascular endothelial growth factor receptor-3/Flt4 mRNA in adult rat central nervous system.
    Hou Y, Shin YJ, Han EJ, Choi JS, Park JM, Cha JH, Choi JY, Lee MY.

    11/26/2011
    expression of erbB, VEGF and its receptors, and ER were determined at varying intensities at different sites of the mammary gland during pregnancy, lactation, and involution periods

    The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland.
    Sagsoz H, Ketani MA.

    07/9/2011
    VEGFR-3 has even broader functions than previously thought, regulating both developmental processes and adult neuronal function in the cerebellum.

    Expression of vascular endothelial growth factor receptor-3 mRNA in the developing rat cerebellum.
    Hou Y, Choi JS, Shin YJ, Cha JH, Choi JY, Chun MH, Lee MY.

    05/21/2011
    The data of this study suggested that VEGFR-3 may be involved in the glial reaction and possibly in the recruitment of monocytic macrophages during ischemic insults.

    Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats.
    Shin YJ, Choi JS, Choi JY, Hou Y, Cha JH, Chun MH, Lee MY.

    01/1/2011
    VEGFR-3 might mediate the regulation of both neurogenesis and adult neuronal function in the rat forebrain and eye.

    Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina.
    Choi JS, Shin YJ, Lee JY, Yun H, Cha JH, Choi JY, Chun MH, Lee MY.

    05/10/2010
    These data indicate that VEGFR-3 is upregulated in subventricular zone astrocytes and immature neurons after focal ischemia, suggesting that VEGFR-3 might mediate the adult neurogenesis after ischemic stroke.

    Enhanced expression of vascular endothelial growth factor receptor-3 in the subventricular zone of stroke-lesioned rats.
    Shin YJ, Choi JS, Choi JY, Cha JH, Chun MH, Lee MY.

    04/19/2010
    Prox1 synergizes with the p50 of NF-kappaB to control VEGFR-3 expression.

    Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.
    Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, Nisato RE, Pepper MS, Zawieja DC, Ran S., Free PMC Article

    02/1/2010
    Immunostaining for the specific lymphatic markers VEGFR-3 revealed an extensive lymphatic vessel system in dental tissues. Unexpected cell staining for the above lymphatic markers was found in the pulp of both molars and incisors in rats.

    Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers.
    Berggreen E, Haug SR, Mkonyi LE, Bletsa A.

    01/21/2010
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