| MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats. | MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats.
Feng L, Wang H, Chen C, Fu J, Zhao L, Zhao X, Geng M, Ren M, Tong L, Li Y, Gu J, Wang C. | 04/18/2024 |
| DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with M feminine Teresa along the purinergic pathways of Eden. | DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden.
Gil-Redondo JC, Queipo MJ, Trueba Y, Llorente-Sáez C, Serrano J, Ortega F, Gómez-Villafuertes R, Pérez-Sen R, Delicado EG., Free PMC Article | 04/10/2024 |
| Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation. | Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation.
Geng M, Shao Q, Fu J, Gu J, Feng L, Zhao L, Liu C, Mu J, Zhang X, Zhao M, Guo X, Song C, Li Y, Wang H, Wang C., Free PMC Article | 03/5/2024 |
| Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test. | Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test.
Vlasov I, Filatova E, Slominsky P, Shadrina M., Free PMC Article | 06/28/2023 |
| RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition. | RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition.
Fan W, Qin Y, Tan J, Li B, Liu Y, Rong J, Shi W, Yu B. | 12/10/2022 |
| Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage. | Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
Flores JJ, Ding Y, Sherchan P, Zhang JH, Tang J., Free PMC Article | 12/10/2022 |
| Edaravone Dexborneol Alleviates Cerebral Ischemic Injury via MKP-1-Mediated Inhibition of MAPKs and Activation of Nrf2. | Edaravone Dexborneol Alleviates Cerebral Ischemic Injury via MKP-1-Mediated Inhibition of MAPKs and Activation of Nrf2.
Zhang W, Yang H, Gao M, Zhang H, Shi L, Yu X, Zhao R, Song J, Du G., Free PMC Article | 10/1/2022 |
| DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway. | DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway.
Shao LL, Gao MM, Gong JX, Yang LY. | 04/2/2022 |
| All-Trans Retinoic Acid Attenuates Blue Light-Induced Apoptosis of Retinal Photoreceptors by Upregulating MKP-1 Expression. | All-Trans Retinoic Acid Attenuates Blue Light-Induced Apoptosis of Retinal Photoreceptors by Upregulating MKP-1 Expression.
Zhuang X, Ma J, Xu S, Zhang M, Xu G, Sun Z. | 01/1/2022 |
| Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration. | Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration.
Langreck C, Wauson E, Nerland D, Lamb B, Folkerts T, Winter L, Lu E, Tague S, McCarson KE, Ploski JE, Banasr M, Duman RS, Roland MM, Babich V, Di Sole F, Duric V. | 11/22/2021 |
| Dual Specificity Phosphatases Support Axon Plasticity and Viability. | Dual Specificity Phosphatases Support Axon Plasticity and Viability.
Chandrasekhar A, Komirishetty P, Areti A, Krishnan A, Zochodne DW. | 08/7/2021 |
| Inhibition of miR1013p protects against sepsisinduced myocardial injury by inhibiting MAPK and NFkappaB pathway activation via the upregulation of DUSP1. | Inhibition of miR‑101‑3p protects against sepsis‑induced myocardial injury by inhibiting MAPK and NF‑κB pathway activation via the upregulation of DUSP1.
Xin Y, Tang L, Chen J, Chen D, Wen W, Han F., Free PMC Article | 07/17/2021 |
| DUSP1 Promotes Microglial Polarization toward M2 Phenotype in the Medial Prefrontal Cortex of Neuropathic Pain Rats via Inhibition of MAPK Pathway. | DUSP1 Promotes Microglial Polarization toward M2 Phenotype in the Medial Prefrontal Cortex of Neuropathic Pain Rats via Inhibition of MAPK Pathway.
Wang X, Jiang Y, Li J, Wang Y, Tian Y, Guo Q, Cheng Z. | 07/3/2021 |
| MiR-101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP-1 mediated MAPK pathway. | MiR-101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP-1 mediated MAPK pathway.
Qiu S, Liu B, Mo Y, Wang X, Zhong L, Han X, Mi F., Free PMC Article | 05/8/2021 |
| MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia-reperfusion injury. | MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia-reperfusion injury.
Ren L, Wang Q, Ma L, Wang D. | 02/27/2021 |
| DEX treatment also effectively inhibited acute stress-induced c-Jun N-terminal kinase (JNK), P38, and BAD signaling pathway activation, and significantly induced MKP-1 activation. | Dexmedetomidine improves acute stress-induced liver injury in rats by regulating MKP-1, inhibiting NF-κB pathway and cell apoptosis.
Sha J, Feng X, Chen Y, Zhang H, Li B, Hu X, Fan H. | 05/30/2020 |
| miR-424 protected PC-12 cells from oxygen glucose deprivation (OGD)-induced injury through direct suppression of MKP-1 expression. | miR-424 protects PC-12 cells from OGD-induced injury by negatively regulating MKP-1.
Cao YX, Wang ZQ, Kang JX, Liu K, Zhao CF, Guo YX, Jiao BH. | 11/9/2019 |
| Study shows that reactive oxygen species overproduction and MAP kinase phosphatase-1 degradation are associated with gastroparesis in a streptozotocin-induced male diabetic rat model. | Reactive oxygen species overproduction and MAP kinase phosphatase-1 degradation are associated with gastroparesis in a streptozotocin-induced male diabetic rat model.
Smiley R, Naik P, McCallum R, Showkat Ali M. | 11/2/2019 |
| Insulin increased while sanguinarine attenuated phosphorylation of MKP-1 at 10 min reperfusion. | The Role of MKP-1 in Insulin-Induced Cardioprotection.
Webster I, Smith A, Lochner A, Huisamen B. | 07/14/2018 |
| Results suggest that miR-101 has functional significance in the pathophysiology of stress-induced dysfunctions in the ventrolateral orbital cortex. MiR-101 may directly regulate DUSP1 expression, and the mechanism underlying the antidepressant effects of miR-101 may involve the negative regulation of DUSP1 expression, which in turn promotes downstream ERK/BDNF signaling. | MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1).
Zhao Y, Wang S, Chu Z, Dang Y, Zhu J, Su X. | 04/14/2018 |
| Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy. | DUSP-1 gene expression is not regulated by promoter methylation in diabetes-associated cardiac hypertrophy.
Singh GB, Khanna S, Raut SK, Sharma S, Sharma R, Khullar M., Free PMC Article | 09/9/2017 |
| miR-200c plays a role in diabetes-associated cardiac hypertrophy by modulating expression of DUSP-1. | MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy.
Singh GB, Raut SK, Khanna S, Kumar A, Sharma S, Prasad R, Khullar M. | 02/18/2017 |
| MKP-1 in the hippocampus might be involved in the etiology of depression, and DNA methylation of MKP-1 gene promoter in the hippocampus did not related with the depression. | Role of hippocampus mitogen-activated protein kinase phosphatase-1 mRNA expression and DNA methylation in the depression of the rats with chronic unpredicted stress.
Wang CH, Zhang XL, Li Y, Wang GD, Wang XK, Dong J, Ning QF. | 12/19/2015 |
| our data show that HuR is a novel target of 15d-PGJ2 and reveal HuR-mediated pre-mRNA processing and mature mRNA stabilization as important regulatory steps in the 15d-PGJ2-induced expression of MKP-1. | MAP kinase phosphatase-1 expression is regulated by 15-deoxy-Δ12,14-prostaglandin J2 via a HuR-dependent post-transcriptional mechanism.
Woo JH, Lee JH, Kim H, Choi Y, Park SM, Joe EH, Jou I. | 08/29/2015 |
| protein phosphatase MKP-1 carries a negative regulation of c-fos gene transcription by dephosphorylation of ERK kinases that are a key signal component under the action of such stress reagent as anisomycin on the E1A + ras-transformed cells | [Protein phosphatase MKP-1 participates in c-fos gene derepression under the action of stress factors on fibroblasts transformed with E1A and cHA-ras oncogenes].
Kukushkin AN, Svetlikova SB, Pospelov VA. | 01/3/2015 |