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    FBXO32 F-box protein 32 [ Homo sapiens (human) ]

    Gene ID: 114907, updated on 19-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice.

    Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice.
    de Macêdo MRC, Marques RF, Silva AJS, Navarro F, Coppi Navarro A.

    07/17/2021
    F-box only protein 32 (FBXO32) directly ubiquitinates C-terminal binding protein 1 (CtBP1), which is required for its stability and nuclear retention.

    FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
    Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P, Tiwari VK., Free PMC Article

    10/6/2018
    Authors found that the FBXO32 and SMAD4 levels were higher in normal tissues than in CRC tissues. The expressions of FBXO32 and SMAD4 were related to clinicopathological parameters in CRC.

    Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-β)/Smad4 Signalling Pathway.
    Yuan X, Zhang Z, Jiang K, Wang X, Li Y., Free PMC Article

    09/1/2018
    role of the muscle specific E3s MuRF-1 and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review)

    The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass.
    Rom O, Reznick AZ.

    12/23/2017
    FBXO32 activates NF-kappaB through IkappaBalpha degradation in inflammatory and genotoxic stress

    FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress.
    Meshram SN, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, Santra MK.

    12/2/2017
    Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 and its transcription factor FOXO3A.

    Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
    Murdoch JD, Rostosky CM, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I., Free PMC Article

    11/25/2017
    Low FBXO32 expression is associated with breast cancer tumorigenesis.

    FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation.
    Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, Liu Z., Free PMC Article

    10/14/2017
    the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system

    Involvement of the FoxO1/MuRF1/Atrogin-1 Signaling Pathway in the Oxidative Stress-Induced Atrophy of Cultured Chronic Obstructive Pulmonary Disease Myotubes.
    Pomiès P, Blaquière M, Maury J, Mercier J, Gouzi F, Hayot M., Free PMC Article

    08/5/2017
    These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.

    Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation.
    Singh P, Li D, Gui Y, Zheng XL.

    05/13/2017
    Our results indicate that abnormal SCF activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .

    FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy.
    Al-Yacoub N, Shaheen R, Awad SM, Kunhi M, Dzimiri N, Nguyen HC, Xiong Y, Al-Buraiki J, Al-Habeeb W, Alkuraya FS, Poizat C., Free PMC Article

    10/8/2016
    Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.

    A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy.
    Al-Hassnan ZN, Shinwari ZM, Wakil SM, Tulbah S, Mohammed S, Rahbeeni Z, Alghamdi M, Rababh M, Colak D, Kaya N, Al-Fayyadh M, Alburaiki J., Free PMC Article

    05/14/2016
    Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 in skeletal muscle.

    1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes.
    Hayakawa N, Fukumura J, Yasuno H, Fujimoto-Ouchi K, Kitamura H.

    01/16/2016
    Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before cancer related cachexia weight loss.

    Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study.
    Yuan L, Han J, Meng Q, Xi Q, Zhuang Q, Jiang Y, Han Y, Zhang B, Fang J, Wu G.

    01/2/2016
    Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles

    Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
    Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS.

    11/28/2015
    FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation.

    FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.
    Mei Z, Zhang D, Hu B, Wang J, Shen X, Xiao W., Free PMC Article

    10/3/2015
    In conclusion, atrogin-1, MuRF1, FOXO1/3A, and eIF3-f mRNA, and protein levels, are differentially regulated by exercise contraction mode but not WPH supplementation combined with hypertrophy-inducing training.

    Influence of divergent exercise contraction mode and whey protein supplementation on atrogin-1, MuRF1, and FOXO1/3A in human skeletal muscle.
    Stefanetti RJ, Lamon S, Rahbek SK, Farup J, Zacharewicz E, Wallace MA, Vendelbo MH, Russell AP, Vissing K.

    01/24/2015
    MAFbx not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass and preventing from cardiac hypertrophy.

    MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart.
    Baskin KK, Rodriguez MR, Kansara S, Chen W, Carranza S, Frazier OH, Glass DJ, Taegtmeyer H., Free PMC Article

    01/17/2015
    FBXO32 methylation status and protein expression were independently associated with survival in ESCC. FBXO32 may be a functional tumor suppressor. Its inactivation through promoter methylation could play an important role in ESCC carcinogenesis.

    Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma.
    Guo W, Zhang M, Shen S, Guo Y, Kuang G, Yang Z, Dong Z.

    12/20/2014
    both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle--REVIEW

    Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.
    Bodine SC, Baehr LM., Free PMC Article

    11/8/2014
    EZH2 is a key factor in the proliferation and survival of PAX3-FOXO1 alveolar RMS cells working, at least in part, by repressing FBXO32

    The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).
    Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall'Agnese A, Walters ZS, Verginelli F, De Sio L, Boldrini R, Inserra A, Bisogno G, Rosolen A, Alaggio R, Ferrari A, Collini P, Locatelli M, Stifani S, Screpanti I, Rutella S, Yu Q, Marquez VE, Shipley J, Valente S, Mai A, Miele L, Puri PL, Locatelli F, Palacios D, Rota R.

    10/18/2014
    ATROGIN1 gene expression is increased in patients with severe burn injury.

    Increased expression of atrogenes and TWEAK family members after severe burn injury in nonburned human skeletal muscle.
    Merritt EK, Thalacker-Mercer A, Cross JM, Windham ST, Thomas SJ, Bamman MM., Free PMC Article

    04/26/2014
    Quadriceps muscle atrogin-1 levels were lower in COPD patients than controls, but similar in patients with a low and normal fat-free mass index. Atrogin1 levels were not associated with quadriceps fiber cross-sectional area or strength in patients.

    MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD.
    Natanek SA, Riddoch-Contreras J, Marsh GS, Hopkinson NS, Moxham J, Man WD, Kemp PR, Polkey MI., Free PMC Article

    04/19/2014
    Resistance exercise resulted in a significant downregulation of MSTN and FBXO32 mRNA expression and a significant upregulation in FSTL3 and SMURF1 mRNA expression, and carbohydrate and protein feeding have little influence on the these markers expression.

    Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity.
    Dalbo VJ, Roberts MD, Hassell S, Kerksick CM.

    08/31/2013
    Data suggest expression of atrogin-1 and MuRF-1 (muscle-specific RING finger protein 1) play role in aging-related decrease in muscle mass (i.e., sarcopenia); up-regulation of atrogin-1/MuRF-1 has potential to prevent/reverse sarcopenia. [REVIEW]

    Atrogin-1, MuRF-1, and sarcopenia.
    Gumucio JP, Mendias CL., Free PMC Article

    06/15/2013
    Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.

    Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.
    Paffett ML, Channell MM, Naik JS, Lucas SN, Campen MJ., Free PMC Article

    03/9/2013
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