Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model. | Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model. Yin M, Smith JA, Chou M, Chan J, Jittayasothorn Y, Gould DB, Caspi RR, Anderson MS, DeFranco AL., Free PMC Article | 02/5/2024 |
A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1. | A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1. Oftedal BE, Berger AH, Bruserud Ø, Goldfarb Y, Sulen A, Breivik L, Hellesen A, Ben-Dor S, Haffner-Krausz R, Knappskog PM, Johansson S, Wolff AS, Bratland E, Abramson J, Husebye ES., Free PMC Article | 11/3/2023 |
Autoimmune regulator (Aire) deficiency results in reduced memory CD8[+] T cells after Listeria monocytogenes infection in a murine model. | Autoimmune regulator (Aire) deficiency results in reduced memory CD8(+) T cells after Listeria monocytogenes infection in a murine model. Feng Y, Yao S, Li S, Peng Z, Feng G, Ma Y, Guo B, Liu H. | 09/15/2023 |
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells. | Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells. Taves MD, Donahue KM, Bian J, Cam MC, Ashwell JD., Free PMC Article | 08/25/2023 |
Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor. | Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor. Artusa P, Lebel MÈ, Barbier C, Memari B, Salehi-Tabar R, Karabatsos S, Ismailova A, Melichar HJ, White JH., Free PMC Article | 07/19/2023 |
AIRE Deficiency Leads to the Development of Alopecia Areata-Like Lesions in Mice. | AIRE Deficiency Leads to the Development of Alopecia Areata‒Like Lesions in Mice. Maglakelidze N, Gao T, Feehan RP, Hobbs RP. | 03/27/2023 |
CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance. | CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance. Michelson DA, Benoist C, Mathis D., Free PMC Article | 12/3/2022 |
PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease. | PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease. Policheni AN, Teh CE, Robbins A, Tuzlak S, Strasser A, Gray DHD., Free PMC Article | 05/14/2022 |
The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids. | The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids. Monteleone-Cassiano AC, Dernowsek JA, Mascarenhas RS, Assis AF, Pitol D, Santos Moreira NC, Sakamoto-Hojo ET, Issa JPM, Donadi EA, Passos GA., Free PMC Article | 04/2/2022 |
Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation. | Attenuate ICOSL and IL-27 in Aire-overexpressing DC2.4 cells suppress TFH cell differentiation. Zou X, Zhang Y, Wang S, Wang X, Yang W, Li Y. | 03/19/2022 |
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium. | Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium. Wang J, Lareau CA, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, Gardner JM., Free PMC Article | 03/12/2022 |
Extrathymic Aire-expressing cells support maternal-fetal tolerance. | Extrathymic Aire-expressing cells support maternal-fetal tolerance. Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC., Free PMC Article | 03/12/2022 |
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. | The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. Heinlein M, Gandolfo LC, Zhao K, Teh CE, Nguyen N, Baell JB, Goldfarb Y, Abramson J, Wichmann J, Voss AK, Strasser A, Smyth GK, Thomas T, Gray DHD. | 03/12/2022 |
Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity. | Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity. Morimoto J, Matsumoto M, Miyazawa R, Yoshida H, Tsuneyama K, Matsumoto M. | 03/5/2022 |
Pathogenic TNF-alpha drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. | Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. Wang Y, Guo L, Yin X, McCarthy EC, Cheng MI, Hoang AT, Chen HC, Patel AY, Allard Trout D, Xu E, Yakobian N, Hugo W, Howard JF Jr, Sheu KM, Hoffmann A, Lechner MG, Su MA., Free PMC Article | 03/5/2022 |
Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens. | Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens. Nishijima H, Matsumoto M, Morimoto J, Hosomichi K, Akiyama N, Akiyama T, Oya T, Tsuneyama K, Yoshida H, Matsumoto M. | 02/5/2022 |
AIRE-overexpressing BMDCs suppress TFH cells through ICOSL to prevent and attenuate autoimmune diabetes in NOD mice. | AIRE-overexpressing BMDCs suppress T(FH) cells through ICOSL to prevent and attenuate autoimmune diabetes in NOD mice. Zou X, Wang S, Zhang Y, Wang X, Zhang R, Yang W, Li Y. | 01/22/2022 |
Autoimmune regulator act in synergism with thymocyte adhesion in the control of lncRNAs in medullary thymic epithelial cells. | Autoimmune regulator act in synergism with thymocyte adhesion in the control of lncRNAs in medullary thymic epithelial cells. Duarte MJ, Mascarenhas RS, Assis AF, Tanaka PP, Speck-Hernandez CA, Passos GA. | 12/25/2021 |
Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers. | Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers. Bansal K, Michelson DA, Ramirez RN, Viny AD, Levine RL, Benoist C, Mathis D., Free PMC Article | 12/18/2021 |
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation. | Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation. Goldfarb Y, Givony T, Kadouri N, Dobeš J, Peligero-Cruz C, Zalayat I, Damari G, Dassa B, Ben-Dor S, Gruper Y, Oftedal BE, Bratland E, Erichsen MM, Berger A, Avin A, Nevo S, Haljasorg U, Kuperman Y, Ulman A, Haffner-Krausz R, Porat Z, Atasoy U, Leshkowitz D, Husebye ES, Abramson J., Free PMC Article | 12/11/2021 |
Multiple Lesions Contribute to Infertility in Males Lacking Autoimmune Regulator. | Multiple Lesions Contribute to Infertility in Males Lacking Autoimmune Regulator. Warren BD, Ahn SH, Brittain KS, Nanjappa MK, Wang H, Wang J, Blanco G, Sanchez G, Fan Y, Petroff BK, Cooke PS, Petroff MG., Free PMC Article | 09/18/2021 |
Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. | Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. Jaini R, Loya MG, King AT, Thacker S, Sarn NB, Yu Q, Stark GR, Eng C., Free PMC Article | 08/21/2021 |
A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation. | A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation. Ferreirinha P, Ribeiro C, Morimoto J, Landry JJM, Matsumoto M, Meireles C, White AJ, Ohigashi I, Araújo L, Benes V, Takahama Y, Anderson G, Matsumoto M, Alves NL., Free PMC Article | 04/17/2021 |
Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells. | Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells. Oliveira EH, Assis AF, Speck-Hernandez CA, Duarte MJ, Passos GA., Free PMC Article | 04/13/2021 |
Aire utilizes its caspase activation recruitment domain (CARD) to form filamentous homo-multimers in vitro, and this assembly mediates foci formation and transcriptional activity. | Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance. Huoh YS, Wu B, Park S, Yang D, Bansal K, Greenwald E, Wong WP, Mathis D, Hur S., Free PMC Article | 07/25/2020 |