Within the endothelial population, cells that transition from haemogenic endothelial to erythro-myeloid progenitors specifically express Alox5 and its co-factor Alox5ap, which control leukotriene production. Functional assays using mouse embryonic stem cells demonstrate that leukotrienes promote haematopoietic progenitor cell generation. | Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC., Free PMC Article | 04/13/2019 |
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance | ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. Elias I, Ferré T, Vilà L, Muñoz S, Casellas A, Garcia M, Molas M, Agudo J, Roca C, Ruberte J, Bosch F, Franckhauser S. | 06/10/2017 |
Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP). | A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. Blevitt JM, Hack MD, Herman K, Chang L, Keith JM, Mirzadegan T, Rao NL, Lebsack AD, Milla ME., Free PMC Article | 12/17/2016 |
BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model. | The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O., Free PMC Article | 01/24/2015 |
FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity. | FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo . Chu J, Lauretti E, Di Meco A, Praticò D., Free PMC Article | 06/7/2014 |
This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice. | The involvement of 5-lipoxygenase activating protein in anxiety-like behavior. Joshi YB, Praticò D., Free PMC Article | 09/14/2013 |
Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity. | Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Yu Z, Ricciotti E, Miwa T, Liu S, Ihida-Stansbury K, Landesberg G, Jones PL, Scalia R, Song WC, Assoian RK, FitzGerald GA., Free PMC Article | 03/23/2013 |
A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner. | 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Park MS, Sohn MH, Kim KE, Park MS, Namgung R, Lee C. | 06/18/2011 |
the 5-LO pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage | The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. Finkensieper A, Kieser S, Bekhite MM, Richter M, Mueller JP, Graebner R, Figulla HR, Sauer H, Wartenberg M. | 06/28/2010 |
Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO activating protein | 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. Horrillo R, González-Périz A, Martínez-Clemente M, López-Parra M, Ferré N, Titos E, Morán-Salvador E, Deulofeu R, Arroyo V, Clària J. | 05/3/2010 |
FLAP mRNA is abundantly expressed in fetal mouse liver from e11.5 until delivery. | Fetal hepatic expression of 5-lipoxygenase activating protein is confined to colonizing hematopoietic cells. Strid T, Karlsson C, Söderström M, Zhang J, Qian H, Sigvardsson M, Hammarström S. | 01/21/2010 |
identify multiprotein complexes for leukotriene synthesis on the outer and inner nuclear membranes of mast cells and neutrophils, centered on the 5-Lipoxygenase-Activating Protein and 5-Lipoxygenase | The nuclear membrane organization of leukotriene synthesis. Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ., Free PMC Article | 01/21/2010 |
This observation supports the hypothesis that 5-LO may be involved in diseases of the brain associated with aging. | The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Chinnici CM, Yao Y, Praticò D. | 01/21/2010 |
Altered 5-lipoxygenase is associated with obesity and bone traits | Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. | 01/21/2010 |
Important role of FLAP/leukotriene pathway in adaptive immunological circuits in vascular and adipose tissue inflammation. May be key regulator of T-cell-driven inflammatory and possible target in treatment of atherosclerosis and metabolic disease. | 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Bäck M, Sultan A, Ovchinnikova O, Hansson GK. | 01/21/2010 |
Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts. | 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A., Free PMC Article | 01/21/2010 |