| The interplay between MMP-12 and t-PA in the brain after ischemic stroke. | The interplay between MMP-12 and t-PA in the brain after ischemic stroke.
Challa SR, Nalamolu KR, Fornal CA, Mohandass A, Mussman JP, Schaibley C, Kashyap A, Sama V, Wang BC, Klopfenstein JD, Pinson DM, Kunamneni A, Veeravalli KK., Free PMC Article | 11/26/2022 |
| elevated 20-hydroxyeicosatetraeonic acid in metabolic syndrome increases matrix metalloproteinase 12 (MMP12) activation leading to increased degradation of elastin, increased large artery stiffness and increased systolic blood pressure. | Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P., Free PMC Article | 06/22/2019 |
| In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling. | HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.
Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ., Free PMC Article | 04/28/2018 |
| MMP-12 plays an adverse role in acute brain damage occurring after ischemic stroke. | Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia.
Chelluboina B, Klopfenstein JD, Pinson DM, Wang DZ, Vemuganti R, Veeravalli KK. | 04/9/2016 |
| Specific knockdown of MMP-12 after focal cerebral ischemia offers neuroprotection. | Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage.
Chelluboina B, Warhekar A, Dillard M, Klopfenstein JD, Pinson DM, Wang DZ, Veeravalli KK., Free PMC Article | 03/5/2016 |
| MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process | Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping.
Sajjan S, Holsinger RM, Fok S, Ebrahimkhani S, Rollo JL, Banati RB, Graeber MB. | 10/17/2015 |
| Inspiratory resistive breathing induces MMP-9 and -12 in the lung of previously healthy rats. | Inspiratory resistive breathing induces MMP-9 and MMP-12 expression in the lung.
Toumpanakis D, Noussia O, Sigala I, Litsiou E, Loverdos K, Zacharatos P, Karavana V, Michailidou T, Magkou C, Zhou Z, Theocharis S, Vassilakopoulos T. | 05/30/2015 |
| MMP-8, MMP-9 and MMP-12 gene and protein expression increased profoundly (p < 0.01), and MMP-13 mRNA and MMP-2 mRNA and protein modestly (p < 0.001) in the anastomoses. | Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair.
Krarup PM, Eld M, Heinemeier K, Jorgensen LN, Hansen MB, Ågren MS. | 03/1/2014 |
| The mRNA and protein expression levels of MMP-12 and Cathepsin E were significantly up-regulated in lung tissues of rats with silicotic pulmonary fibrosis. | [Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
Xu HR, Wang XH, Ma XB, Hou WN, Zhu L, Xiang JC, Sun RJ. | 03/16/2013 |
| Macrophage-derived MMP-12 regulates elastin degradation even in progressive experimental liver fibrosis. | Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.
Pellicoro A, Aucott RL, Ramachandran P, Robson AJ, Fallowfield JA, Snowdon VK, Hartland SN, Vernon M, Duffield JS, Benyon RC, Forbes SJ, Iredale JP. | 08/4/2012 |
| By regulating the proliferation of corneal epithelial cells, Wnt-7a and MMP-12 appear to contribute to corneal wound healing | Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing.
Lyu J, Joo CK. | 01/21/2010 |
| MMP-12 produced by macrophages that infiltrate the glomeruli and form a crescent in Bowman's space is a major factor for the development of crescentic glomerulonephritis. | Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis.
Kaneko Y, Sakatsume M, Xie Y, Kuroda T, Igashima M, Narita I, Gejyo F. | 01/21/2010 |