| Finally, we detected the variance during regeneration progress through the rat walk footprint test. In summary, all these evidences demonstrated that Sam68 might participate in Schwann cell proliferation partially via PI3K/Akt pathway and also regulate regeneration after sciatic nerve crush. | Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush.
Wu W, Liu Y, Wang Y. | 05/13/2017 |
| In conclusion, miRNA-221 exerts cytoprotective effects in hypoxia-reoxygenation injury in association with alterations in autophagic cell injury. Mir-221 may constitute is a novel therapeutic target in the treatment of cardiac I/R injury. | Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways.
Chen Q, Zhou Y, Richards AM, Wang P. | 05/13/2017 |
| Sam68 might be illustrated in the apoptosis of neurons and proliferation of astrocytes after spinal cord injury. | Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.
Chen X, Liu L, Qian R, Liu J, Yao Y, Jiang Z, Song X, Ren J, Zhang F. | 03/18/2017 |
| Sam68 Promotes NF-kappaB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis | Sam68 Promotes NF-κB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis.
Xu L, Sun C, Zhang S, Xu X, Zhai L, Wang Y, Wang S, Liu Z, Cheng H, Xiao M, Tao R, Zhang D. | 08/13/2016 |
| Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model. | Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model.
Chen Z, Fu Q, Shen B, Huang X, Wang K, He P, Li F, Zhang F, Shen H. | 01/10/2015 |
| p62/ZIP not only plays a key role in scavenging protein aggregates during autophagy, but it is also involved in preventing oxidative injury and alleviating ER stress through the Keap1-Nrf2-ARE signaling pathway during cerebral ischaemia/reperfusion injury | Regulation of endoplasmic reticulum stress in rat cortex by p62/ZIP through the Keap1-Nrf2-ARE signalling pathway after transient focal cerebral ischaemia.
Wang W, Kang J, Li H, Su J, Wu J, Xu Y, Yu H, Xiang X, Yi H, Lu Y, Sun L. | 03/8/2014 |
| The A20 zinc-finger (Znf) domain of ZNF216 and the ubiquitin (Ub) UBA domain of p62 are capable of independent binding interactions in forming a ternary complex with a single Ub. | Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.
Garner TP, Strachan J, Shedden EC, Long JE, Cavey JR, Shaw B, Layfield R, Searle MS. | 12/10/2011 |
| Sam68 undergoes activity-responsive translocation to the soma and dendrites of hippocampal neurons in primary culture | Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons.
Ben Fredj N, Grange J, Sadoul R, Richard S, Goldberg Y, Boyer V. | 01/21/2010 |
| Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling | Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling.
Najib S, Sánchez-Margalet V. | 01/21/2010 |
| Sam68 may accompany and, conceivably, regulate mature mRNAs during nuclear export, somatodendritic transport, and translation. | Somatodendritic localization and mRNA association of the splicing regulatory protein Sam68 in the hippocampus and cortex.
Grange J, Boyer V, Fabian-Fine R, Fredj NB, Sadoul R, Goldberg Y. | 01/21/2010 |
| Sam68 suppresses BRK-induced cell proliferation, and regulates intranuclear localization and cell cycle progression | Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
Lukong KE, Larocque D, Tyner AL, Richard S. | 01/21/2010 |
| PI3K and SAM68 are involved in ANG II signaling, and SAM68 is differentially regulated in vascular smooth muscle cells(VSMC) from spontaneously hypertensive rats(SHR). May contribute to enhanced ANG II signaling and altered VSMC growth in SHR. | SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension.
El Mabrouk M, Diep QN, Benkirane K, Touyz RM, Schiffrin EL. | 01/21/2010 |