| TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy. | TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy.
Xu Z, Zheng T, Zheng Z, Jiang W, Huang L, Deng K, Yuan L, Qin F, Sun Y, Qin J, Li S., Free PMC Article | 10/25/2023 |
| An attempt to unravel the association of TAGAP gene SNPs with rheumatoid arthritis in the Indian population using high-resolution melting analysis. | An attempt to unravel the association of TAGAP gene SNPs with rheumatoid arthritis in the Indian population using high-resolution melting analysis.
Shri Preethi M, Asha Devi S. | 06/25/2022 |
| These findings indicate that increased TAGAP expression is a distinguishing feature of inflammatory disease and further highlight the role of TAGAP in rheumatoid arthritis susceptibility. | T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis.
Arshad M, Bhatti A, John P, Jalil F, Borghese F, Kawalkowska JZ, Williams RO, Clanchy FIL. | 05/4/2019 |
| This is the first comprehensive study, where TAGAP gene variants were analyzed using in silico tools hence will be of great help while considering large scale studies and also in developing precision medicines for cure of diseases related to these polymorphisms | Identification and in silico analysis of functional SNPs of human TAGAP protein: A comprehensive study.
Arshad M, Bhatti A, John P., Free PMC Article | 02/3/2018 |
| Results suggested that TAGAP rs1738074 polymorphism could be considered as a risk factor in the prevalence of multiple sclerosis in the Iranian population | Association of rs1738074 polymorphism of TAGAP gene with susceptibility to multiple sclerosis in the Iranian population.
Jazaeri A, Vallian S. | 11/11/2017 |
| meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in Europeans and Americans | Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
Huang SQ, Zhang N, Zhou ZX, Huang CC, Zeng CL, Xiao D, Guo CC, Han YJ, Ye XH, Ye XG, Ou ML, Zhang BH, Liu Y, Zeng EY, Yang G, Jing CX., Free PMC Article | 06/24/2017 |
| IL2RA and TAGAP are novel vitamin D target genes. The vitamin D response is observed in samples from both the multiple sclerosis (MS) patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes. | The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjølgerud A, Holmøy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A., Free PMC Article | 12/17/2016 |
| SNPs in TAGAP are associated with increased risk of candidemia. | Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JWM, Joosten LAB, Bochud PY, Marchetti O, Perfect JR, Xavier R, Kullberg BJ, Wijmenga C, Netea MG., Free PMC Article | 07/25/2015 |
| Colonic expression of TAGAP in Crohn's disease varies according to disease severity and location, being the most elevated in patients with severe disease in the sigmoid colon | T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.
Connelly TM, Berg AS, Harris LR 3rd, Hegarty JP, Ruggiero FM, Deiling SM, Brinton DL, Koltun WA. | 09/6/2014 |
| we suggest that polymorphism rs212389 better predicts the association of TAGAP locus with RA. | Validation of the TAGAP rs212389 polymorphism in rheumatoid arthritis susceptibility.
Chatzikyriakidou A, Voulgari PV, Lambropoulos A, Georgiou I, Drosos AA. | 06/28/2014 |
| Rs212388 single nucleotide polymorphism most significantly correlated with the presence and severity of anal disease in ileocolonic Crohn's disease. | Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease.
Connelly TM, Sehgal R, Berg AS, Hegarty JP, Deiling S, Stewart DB, Poritz LS, Koltun WA. | 12/22/2012 |
| SNPs in regulatory regions of TAGAP and an intronic SNP (TNFAIP3) are potential susceptibility loci in African Americans. | Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.
Perkins EA, Landis D, Causey ZL, Edberg Y, Reynolds RJ, Hughes LB, Gregersen PK, Kimberly RP, Edberg JC, Bridges SL Jr, Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Investigators., Free PMC Article | 07/14/2012 |
| study has refined the TAGAP signal of association to a single haplotype in rheumatoid arthritis (RA), and in doing so provides conclusive statistical evidence that the TAGAP locus is associated with RA risk | Fine mapping the TAGAP risk locus in rheumatoid arthritis.
Chen R, Stahl EA, Kurreeman FA, Gregersen PK, Siminovitch KA, Worthington J, Padyukov L, Raychaudhuri S, Plenge RM., Free PMC Article | 09/10/2011 |
| there is strong evidence that variation within the TAGAP gene is associated with rheumatoid arthritis, type 1 diabetes and coeliac disease | Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.
Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Yorkshire Early Arthritis Consortium, Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A, Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Yorkshire Early Arthritis Consortium, Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A., Free PMC Articles: PMC2991006, PMC2991006 | 04/2/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesOverlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.
Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Yorkshire Early Arthritis Consortium, Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A, Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Yorkshire Early Arthritis Consortium, Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR study group, Worthington J, Thomson W. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.
Amundsen SS, Rundberg J, Adamovic S, Gudjónsdóttir AH, Ascher H, Ek J, Nilsson S, Lie BA, Naluai AT, Sollid LM. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA. Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.
Romanos J, Barisani D, Trynka G, Zhernakova A, Bardella MT, Wijmenga C. | 10/1/2008 |
| Genome-wide association study of gene-disease association. (HuGE Navigator) | Newly identified genetic risk variants for celiac disease related to the immune response.
Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA., Free PMC Article | 04/3/2008 |