| Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity. | Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity.
Wang Y, Yang Z, Wang R, Zheng Y, Han Z, Fan J, Yan F, Liu P, Luo Y., Free PMC Article | 02/23/2024 |
| A conserved annexin A6-mediated membrane repair mechanism in muscle, heart, and nerve. | A conserved annexin A6-mediated membrane repair mechanism in muscle, heart, and nerve.
Demonbreun AR, Bogdanovic E, Vaught LA, Reiser NL, Fallon KS, Long AM, Oosterbaan CC, Hadhazy M, Page PG, Joseph PRB, Cowen G, Telenson AM, Khatri A, Sadleir KR, Vassar R, McNally EM., Free PMC Article | 07/30/2022 |
| Annexin A6 Is Critical to Maintain Glucose Homeostasis and Survival During Liver Regeneration in Mice. | Annexin A6 Is Critical to Maintain Glucose Homeostasis and Survival During Liver Regeneration in Mice.
Alvarez-Guaita A, Blanco-Muñoz P, Meneses-Salas E, Wahba M, Pollock AH, Jose J, Casado M, Bosch M, Artuch R, Gaus K, Lu A, Pol A, Tebar F, Moss SE, Grewal T, Enrich C, Rentero C. | 05/8/2021 |
| Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein-Deficient Mice. | Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein-Deficient Mice.
Meneses-Salas E, Garcia-Forn M, Castany-Pladevall C, Lu A, Fajardo A, Jose J, Wahba M, Bosch M, Pol A, Tebar F, Klein AD, Zanlungo S, Pérez-Navarro E, Grewal T, Enrich C, Rentero C. | 03/20/2021 |
| annexin overexpression promoted external blebs enriched in Ca2+ and correlated with a reduction of intracellular Ca2+ at the injury site. Annexin A6 overexpression reduced membrane injury, consistent with enhanced repair. Treatment with recombinant annexin A6 protected against acute muscle injury in vitro and in vivo. | Recombinant annexin A6 promotes membrane repair and protects against muscle injury.
Demonbreun AR, Fallon KS, Oosterbaan CC, Bogdanovic E, Warner JL, Sell JJ, Page PG, Quattrocelli M, Barefield DY, McNally EM., Free PMC Article | 06/13/2020 |
| Annexin A6-deficient mice showed increased sensitivity to mechanical stimuli, overexpression of annexin A6 in sensory neurons attenuated mechanical pain in a mouse model of osteoarthritis | Inhibition of somatosensory mechanotransduction by annexin A6.
Raouf R, Lolignier S, Sexton JE, Millet Q, Santana-Varela S, Biller A, Fuller AM, Pereira V, Choudhary JS, Collins MO, Moss SE, Lewis R, Tordo J, Henckaerts E, Linden M, Wood JN., Free PMC Article | 10/26/2019 |
| AnxA6 contributing to the fine-tuning of hepatic glucose metabolism with potential consequences for the systemic control of glucose in health and disease. | Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.
Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T., Free PMC Article | 01/26/2019 |
| Findings define a novel role for AnxA6 in articular chondrocytes via its modulation of Wnt/beta-catenin and NF- kappaB signaling activities and the cross-talk between these two signaling pathways. | Annexin A6 regulates catabolic events in articular chondrocytes via the modulation of NF-κB and Wnt/ß-catenin signaling.
Minashima T, Kirsch T., Free PMC Article | 12/22/2018 |
| AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment. | Annexin A6 regulates interleukin-2-mediated T-cell proliferation.
Cornely R, Pollock AH, Rentero C, Norris SE, Alvarez-Guaita A, Grewal T, Mitchell T, Enrich C, Moss SE, Parton RG, Rossy J, Gaus K. | 12/2/2017 |
| AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release. | Annexin A6 regulates adipocyte lipid storage and adiponectin release.
Krautbauer S, Haberl EM, Eisinger K, Pohl R, Rein-Fischboeck L, Rentero C, Alvarez-Guaita A, Enrich C, Grewal T, Buechler C, Neumeier M. | 11/18/2017 |
| morphological analysis of liver sections from annexin A6-KO mice revealed significantly lower lipid droplet numbers compared to wildtype animals | Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation.
Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hanh J, Nagarajan SR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Grewal T. | 10/21/2017 |
| Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains | Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains.
Alvarez-Guaita A, Vilà de Muga S, Owen DM, Williamson D, Magenau A, García-Melero A, Reverter M, Hoque M, Cairns R, Cornely R, Tebar F, Grewal T, Gaus K, Ayala-Sanmartín J, Enrich C, Rentero C., Free PMC Article | 12/26/2015 |
| Transient knockdown of annexin A6 and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001). | Differential skeletal muscle proteome of high- and low-active mice.
Ferguson DP, Dangott LJ, Schmitt EE, Vellers HL, Lightfoot JT., Free PMC Article | 05/16/2015 |
| Anxa6 is a modifier of muscular dystrophy and membrane repair after injury. | Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.
Swaggart KA, Demonbreun AR, Vo AH, Swanson KE, Kim EY, Fahrenbach JP, Holley-Cuthrell J, Eskin A, Chen Z, Squire K, Heydemann A, Palmer AA, Nelson SF, McNally EM., Free PMC Article | 06/21/2014 |
| anxA6 inhibits Drp1 activity, and Ca(2+)-binding to anxA6 relieves this inhibition to permit Drp1-mediated mitochondrial | Regulation of mitochondrial morphogenesis by annexin A6.
Chlystun M, Campanella M, Law AL, Duchen MR, Fatimathas L, Levine TP, Gerke V, Moss SE., Free PMC Article | 07/6/2013 |
| Annexins and collagen X may rather fulfill functions in growth plate cartilage not directly linked to the mineralization process. | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.
Grskovic I, Kutsch A, Frie C, Groma G, Stermann J, Schlötzer-Schrehardt U, Niehoff A, Moss SE, Rosenbaum S, Pöschl E, Chmielewski M, Rappl G, Abken H, Bateman JF, Cheah KS, Paulsson M, Brachvogel B. | 03/30/2013 |
| These results indicate that annexins A5 and A6 may not represent the essential annexins that promote mineralization in vivo. | Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.
Belluoccio D, Grskovic I, Niehoff A, Schlötzer-Schrehardt U, Rosenbaum S, Etich J, Frie C, Pausch F, Moss SE, Pöschl E, Bateman JF, Brachvogel B. | 07/12/2010 |
| distinct functions of AnxA6 isoforms in membrane dynamics | Calcium- and pH-dependent localization of annexin A6 isoforms in Balb/3T3 fibroblasts reflecting their potential participation in vesicular transport.
Strzelecka-Kiliszek A, Buszewska ME, Podszywalow-Bartnicka P, Pikula S, Otulak K, Buchet R, Bandorowicz-Pikula J. | 01/21/2010 |
| cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 at neutral pH | Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.
Ling TY, Chen CL, Huang YH, Liu IH, Huang SS, Huang JS. | 01/21/2010 |
| Annexin VI regulation of myocardial contraction. | Annexin VI regulation of cardiac function.
Kaetzel MA, Dedman JR. | 01/21/2010 |