The role of ATG5 beyond Atg8ylation and autophagy. | The role of ATG5 beyond Atg8ylation and autophagy. Wang F, Trosdal ES, Paddar MA, Duque TLA, Allers L, Mudd M, Akepati PR, Javed R, Jia J, Salemi M, Phinney B, Deretic V., | 02/6/2024 |
ATG5 Knockdown Attenuates Ischemia-Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. | ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. Zhu H, Zhong Y, Chen R, Wang L, Li Y, Jian Z, Gu L, Xiong X. | 01/26/2024 |
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy. | TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy. Huang X, Ye C, Zhao X, Tong Y, Lin W, Huang Q, Zheng Y, Wang J, Zhang A, Mo Y., Free PMC Article | 12/6/2023 |
Autophagy protein 5 controls flow-dependent endothelial functions. | Autophagy protein 5 controls flow-dependent endothelial functions. Nivoit P, Mathivet T, Wu J, Salemkour Y, Sankar DS, Baudrie V, Bourreau J, Guihot AL, Vessieres E, Lemitre M, Bocca C, Teillon J, Le Gall M, Chipont A, Robidel E, Dhaun N, Camerer E, Reynier P, Roux E, Couffinhal T, Hadoke PWF, Silvestre JS, Guillonneau X, Bonnin P, Henrion D, Dengjel J, Tharaux PL, Lenoir O., Free PMC Article | 07/24/2023 |
ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion. | ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion. Wang F, Peters R, Jia J, Mudd M, Salemi M, Allers L, Javed R, Duque TLA, Paddar MA, Trosdal ES, Phinney B, Deretic V., | 05/28/2023 |
Loss of ATG5 in KRT14(+) cells leads to accumulated functional impairments of salivary glands via pyroptosis. | Loss of ATG5 in KRT14(+) cells leads to accumulated functional impairments of salivary glands via pyroptosis. Yu S, Wang H, Liu M, Pei F, Liu H, Zhang J, Zhang L, Li Q, Chen Z. | 11/19/2022 |
MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer. | MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer. Hamada K, Kurashige T, Shimamura M, Arakawa H, Nakamura Y, Nagayama Y., Free PMC Article | 10/8/2022 |
The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells. | The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells. Pei X, Wang H, Xu P, Liang K, Yuan L. | 10/8/2022 |
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. | ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy. Wang D, Yuan T, Liu J, Wen Z, Shen Y, Tang J, Wang Z, Wu X. | 08/13/2022 |
LncRNA CCAT1 Upregulates ATG5 to Enhance Autophagy and Promote Gastric Cancer Development by Absorbing miR-140-3p. | LncRNA CCAT1 Upregulates ATG5 to Enhance Autophagy and Promote Gastric Cancer Development by Absorbing miR-140-3p. Yang F, Peng ZX, Ji WD, Yu JD, Qian C, Liu JD, Fang GE. | 07/23/2022 |
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling. | Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling. Ljubojević-Holzer S, Kraler S, Djalinac N, Abdellatif M, Voglhuber J, Schipke J, Schmidt M, Kling KM, Franke GT, Herbst V, Zirlik A, von Lewinski D, Scherr D, Rainer PP, Kohlhaas M, Nickel A, Mühlfeld C, Maack C, Sedej S., Free PMC Article | 05/21/2022 |
Autophagy in PDGFRalpha+ mesenchymal cells is essential for intestinal stem cell survival. | Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival. Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E., Free PMC Article | 05/14/2022 |
ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. | ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Srimat Kandadai K, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer D, Prinz M, Lünemann JD., Free PMC Article | 03/26/2022 |
Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling. | Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling. Yan S, Khambu B, Chen X, Dong Z, Guo G, Yin XM., Free PMC Article | 03/12/2022 |
Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. | Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. Merkley SD, Goodfellow SM, Guo Y, Wilton ZER, Byrum JR, Schwalm KC, Dinwiddie DL, Gullapalli RR, Deretic V, Jimenez Hernandez A, Bradfute SB, In JG, Castillo EF., Free PMC Article | 02/26/2022 |
Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5. | Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5. Zhang J, Zhao L, Li Y, Dong H, Zhang H, Zhang Y, Ma T, Yang L, Gao D, Wang X, Jiang H, Li C, Wang A, Jin Y, Chen H. | 02/19/2022 |
Longchain noncoding RNA GAS5 promotes cell autophagy by modulating the miR181c5p/ATG5 and miR1192/ATG12 axes. | Long‑chain non‑coding RNA GAS5 promotes cell autophagy by modulating the miR‑181c‑5p/ATG5 and miR‑1192/ATG12 axes. Xu T, Xu X, Chu Y, Jiang D, Xu G., Free PMC Article | 02/12/2022 |
Alteration of autophagy-related protein 5 (ATG5) levels and Atg5 gene expression in diabetes mellitus with and without complications. | Alteration of autophagy-related protein 5 (ATG5) levels and Atg5 gene expression in diabetes mellitus with and without complications. Yassin R, Tadmor H, Farber E, Igbariye A, Armaly-Nakhoul A, Dahan I, Nakhoul F, Nakhoul N., Free PMC Article | 02/5/2022 |
Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5(+/-) mice. | Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5(+/-) mice. Zhang R, Chen Y, Wang X, Tian H, Liu H, Xiang Z, Qi D, Huang JH, Wu E, Ding X, Wang X., Free PMC Article | 01/15/2022 |
Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice. | Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice. Huang Q, Liu Y, Zhang S, Yap YT, Li W, Zhang D, Gardner A, Zhang L, Song S, Hess RA, Zhang Z., Free PMC Article | 01/15/2022 |
A Central Role for Atg5 in Microbiota-Dependent Foxp3(+) RORgammat(+) Treg Cell Preservation to Maintain Intestinal Immune Homeostasis. | A Central Role for Atg5 in Microbiota-Dependent Foxp3(+) RORγt(+) Treg Cell Preservation to Maintain Intestinal Immune Homeostasis. Plaza-Sirvent C, Zhao B, Bronietzki AW, Pils MC, Tafrishi N, Schuster M, Strowig T, Schmitz I., Free PMC Article | 12/25/2021 |
ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions. | ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions. Germic N, Hosseini A, Stojkov D, Oberson K, Claus M, Benarafa C, Calzavarini S, Angelillo-Scherrer A, Arnold IC, Müller A, Riether C, Yousefi S, Simon HU., Free PMC Article | 12/11/2021 |
Mechanism of lncRNA-ANRIL/miR-181b in autophagy of cardiomyocytes in mice with uremia by targeting ATG5. | Mechanism of lncRNA-ANRIL/miR-181b in autophagy of cardiomyocytes in mice with uremia by targeting ATG5. Xu Y, Chen J, Wang M, Yu R, Zou W, Shen W., Free PMC Article | 11/22/2021 |
Altered metabolism by autophagy defection affect liver regeneration. | Altered metabolism by autophagy defection affect liver regeneration. Chen Y, Xu Z, Zeng Y, Liu J, Wang X, Kang Y., Free PMC Article | 10/2/2021 |
Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner. | Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner. Nomura N, Ito C, Ooshio T, Tadokoro Y, Kohno S, Ueno M, Kobayashi M, Kasahara A, Takase Y, Kurayoshi K, Si S, Takahashi C, Komatsu M, Yanagawa T, Hirao A., Free PMC Article | 10/2/2021 |