| XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis. | XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
Hong R, Tan Y, Tian X, Huang Z, Wang J, Ni H, Yang J, Bu W, Yang S, Li T, Yu F, Zhong W, Sun T, Wang X, Li D, Liu M, Yang Y, Zhou J., Free PMC Article | 03/15/2024 |
| Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury. | Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.
Reigada D, Maza RM, Muñoz-Galdeano T, Barreda-Manso MA, Soto A, Lindholm D, Navarro-Ruíz R, Nieto-Díaz M., Free PMC Article | 02/17/2023 |
| XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. | XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Daoud M, Broxtermann PN, Schorn F, Werthenbach JP, Seeger JM, Schiffmann LM, Brinkmann K, Vucic D, Tüting T, Mauch C, Kulms D, Zigrino P, Kashkar H., Free PMC Article | 06/25/2022 |
| Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation. | Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
Strigli A, Gopalakrishnan S, Zeissig Y, Basic M, Wang J, Schwerd T, Doms S, Peuker K, Hartwig J, Harder J, Hönscheid P, Arnold P, Kurth T, Rost F, Petersen BS, Forster M, Franke A, Kelsen JR, Rohlfs M, Klein C, Muise AM, Warner N, Nambu R, Mayerle J, Török HP, Linkermann A, Muders MH, Baretton GB, Hampe J, Aust DE, Baines JF, Bleich A, Zeissig S. | 03/12/2022 |
| XIAP prevents TNF-driven inflammation in the terminal ileum of mice. In Xiap-/- mice, TNFR1 signaling kills Paneth cells and TNFR1/TNFR2 signaling kills dendritic cells. Together this drives dysbiosis. | XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. | 11/15/2021 |
| MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP. | MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.
Wang J, Dong G, Chi W, Nie Y. | 07/24/2021 |
| XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway. | XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
Gao D, Wu H, Jie H, Liang M, Yu D, Feng Y, Balasubramanian K, Zheng G, Yang J, He J. | 07/3/2021 |
| Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner. | Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.
Singh AP, Hung YH, Shanahan MT, Kanke M, Bonfini A, Dame MK, Biraud M, Peck BCE, Oyesola OO, Freund JM, Cubitt RL, Curry EG, Gonzalez LM, Bewick GA, Tait-Wojno ED, Kurpios NA, Ding S, Spence JR, Dekaney CM, Buchon N, Sethupathy P., Free PMC Article | 05/8/2021 |
| SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. | SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Coccia E, Planells-Ferrer L, Badillos-Rodríguez R, Pascual M, Segura MF, Fernández-Hernández R, López-Soriano J, Garí E, Soriano E, Barneda-Zahonero B, Moubarak RS, Pérez-García MJ, Comella JX., Free PMC Article | 02/20/2021 |
| Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress. | Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.
Zilu S, Qian H, Haibin W, Chenxu G, Deshuai L, Qiang L, Linfeng H, Jun T, Minxuan X., Free PMC Article | 10/31/2020 |
| Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development. | Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development.
Liu X, Castle V, Taketo T., Free PMC Article | 09/12/2020 |
| IL-17-induced STEAP4-dependent cellular copper uptake is critical for colon tumor formation in a murine model of colitis-associated tumorigenesis and STEAP4 expression correlates with IL-17 level and XIAP activation in human colon cancer. | Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, Jia S, Fox PL, Huang E, Pizarro TT, Kalady MF, Jackson MW, Bao S, Sen GC, Stark GR, Chang CJ, Li X., Free PMC Article | 06/6/2020 |
| Data show that X-linked inhibitor of apoptosis E3 ubiquitin-protein ligase XIAP (XIAP) plays an important role to protect from graft vs host disease (GVHD). | XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
Müller N, Fischer JC, Yabal M, Haas T, Poeck H, Jost PJ. | 05/30/2020 |
| XIAP has a role in regulating inflammasome activation in retinal pigment epithelium. | The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis.
Gao J, Cui JZ, Wang A, Chen HHR, Fong A, Matsubara JA., Free PMC Article | 02/15/2020 |
| IAP inhibition or loss of both cIAP2 and XIAP resulted in a strong blockage in autophagic flux and mitophagy, suggesting that XIAP deficiency may also drive Crohn's Disease due to defects in autophagy. | Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.
Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Häcker G, Gentle IE., Free PMC Article | 11/9/2019 |
| It was demonstrated that cryopreservation reduces the expression of XIAP and decreases the survival rate of blastocysts. | Role of X-linked inhibitor of apoptosis (XIAP) in frozen and thawed dormant and normal-hatched murine blastocysts.
Gu M, Liu D, Ni H, Sheng X, Pauciullo A, Qi X, Liu Y, Guo Y. | 02/23/2019 |
| Differentiation of macrophages increased the expression of pro-inflammatory cytokines but reduced RipK1-dependent cell death and the RipK3-caspase-8 interaction. The expression of the anti-apoptotic mediators, X-linked inhibitor of apoptosis protein (XIAP) and caspase-like apoptosis regulatory protein (cFLIPL), also increased in differentiated macrophages, which inhibited caspase activation. | Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.
Rijal D, Ariana A, Wight A, Kim K, Alturki NA, Aamir Z, Ametepe ES, Korneluk RG, Tiedje C, Menon MB, Gaestel M, McComb S, Sad S., Free PMC Article | 02/16/2019 |
| Results demonstrate that XIAP-regulated Erks/nucleolin/RhoGDIbeta axis promoted BC invasion and lung metastasis. | XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability.
Yu Y, Jin H, Xu J, Gu J, Li X, Xie Q, Huang H, Li J, Tian Z, Jiang G, Chen C, He F, Wu XR, Huang C., Free PMC Article | 01/12/2019 |
| The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. | FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.
Martínez-Mármol R, Barneda-Zahonero B, Soto D, Andrés RM, Coccia E, Gasull X, Planells-Ferrer L, Moubarak RS, Soriano E, Comella JX., Free PMC Article | 04/28/2018 |
| These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations. | XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE. | 04/7/2018 |
| There was a significantly decreased percentage of IL-17A-producing CD4 T cells in mice receiving Tregs from xIAP mice. xIAP appears dispensable for the generation of induced Treg cells as well as function of natural Treg cells. There appeared to be a role of xIAP in generation of IL-17-producing cells from either naive CD4 T cells or Treg cells. | Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency.
Gurram B, Hammelev E, Syverson G, Haribhai D, Yan K, Simpson P, Salzman N, Verbsky JW. | 12/30/2017 |
| Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha. | IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Shekhar TM, Miles MA, Gupte A, Taylor S, Tascone B, Walkley CR, Hawkins CJ., Free PMC Article | 12/23/2017 |
| Deletion of XIAP switches cell death away from necrosis to apoptosis. | Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity.
Liu Y, Chen XD, Yu J, Chi JL, Long FW, Yang HW, Chen KL, Lv ZY, Zhou B, Peng ZH, Sun XF, Li Y, Zhou ZG., Free PMC Article | 10/28/2017 |
| These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition. | The X-linked inhibitor of apoptosis regulates long-term depression and learning rate.
Gibon J, Unsain N, Gamache K, Thomas RA, De Leon A, Johnstone A, Nader K, Séguéla P, Barker PA. | 08/26/2017 |
| XIAP antagonizes the switch from TNFalpha-induced apoptosis to necroptosis in mouse neutrophils. | Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.
Wicki S, Gurzeler U, Wei-Lynn Wong W, Jost PJ, Bachmann D, Kaufmann T., Free PMC Article | 08/5/2017 |