| Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths. | Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
Vainorius G, Novatchkova M, Michlits G, Baar JC, Raupach C, Lee J, Yelagandula R, Wernig M, Elling U., Free PMC Article | 09/8/2023 |
| Neurog2 regulates Isl1 to modulate horizontal cell number. | Neurog2 regulates Isl1 to modulate horizontal cell number.
Keeley PW, Patel PS, Ryu MS, Reese BE., Free PMC Article | 01/14/2023 |
| Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1. | Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1.
Zhou M, Tao X, Sui M, Cui M, Liu D, Wang B, Wang T, Zheng Y, Luo J, Mu Y, Wan F, Zhu LQ, Zhang B., Free PMC Article | 03/5/2022 |
| Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. | Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
Kempf J, Knelles K, Hersbach BA, Petrik D, Riedemann T, Bednarova V, Janjic A, Simon-Ebert T, Enard W, Smialowski P, Götz M, Masserdotti G., Free PMC Article | 02/12/2022 |
| A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord. | A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
Biga V, Hawley J, Soto X, Johns E, Han D, Bennett H, Adamson AD, Kursawe J, Glendinning P, Manning CS, Papalopulu N., Free PMC Article | 01/8/2022 |
| Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord. | Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.
Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, Lu D, Geng J, Rao Z, Sun L, Xu J, Shi Y, Wang X, Liu Y., Free PMC Article | 09/18/2021 |
| Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. | Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
Kaufman ML, Goodson NB, Park KU, Schwanke M, Office E, Schneider SR, Abraham J, Hensley A, Jones KL, Brzezinski JA., Free PMC Article | 08/7/2021 |
| WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression. | WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
Jiang M, Yu D, Xie B, Huang H, Lu W, Qiu M, Dai ZM., Free PMC Article | 08/7/2021 |
| Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis. | Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis.
Aslanpour S, Han S, Schuurmans C, Kurrasch DM., Free PMC Article | 10/3/2020 |
| Overexpression of Fbxo9 in neural crest progenitors down-regulated Neurog2 protein expression through ubiquitination and promoted the glial lineage at the expense of neuronal differentiation. | Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization.
Liu JA, Tai A, Hong J, Cheung MPL, Sham MH, Cheah KSE, Cheung CW, Cheung M., Free PMC Article | 07/18/2020 |
| we demonstrated the role of Id2 in promoting axonal growth by elevating the expression of Ngn2, a neural progenitor cell expressing gene, in post-mitotic neurons | Inhibitor of DNA binding 2 promotes axonal growth through upregulation of Neurogenin2.
Huang Z, Liu J, Jin J, Chen Q, Shields LBE, Zhang YP, Shields CB, Zhou L, Zhou B, Yu P. | 02/29/2020 |
| The Wnt signaling pathway inhibits early astrogliogenesis via a Ngn2-dependent transcriptional repression mechanism. | WNT signaling represses astrogliogenesis via Ngn2-dependent direct suppression of astrocyte gene expression.
Sun S, Zhu XJ, Huang H, Guo W, Tang T, Xie B, Xu X, Zhang Z, Shen Y, Dai ZM, Qiu M. | 01/18/2020 |
| In the Neurog2(-/-) mouse, in addition to the normal Purkinje cell expression, zebrin II is also expressed in a population of cells with a morphology characteristic of microglia. This identity was confirmed by double immunohistochemistry for zebrin II and the microglial marker, Iba1. The expression of zebrin II in cerebellar microglia is not restricted by zone or stripe or lamina. | Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum of Neurogenin 2 Null Mice.
Rahimi-Balaei M, Jiao X, Shabanipour S, Dixit R, Schuurmans C, Marzban H. | 05/25/2019 |
| data support the hypothesis that Neurog2 acts at the top of a retinal bHLH transcription factor hierarchy. Neurog2 simultaneously promotes terminal cell cycle exit and retinal ganglion cell differentiation. | Integral bHLH factor regulation of cell cycle exit and RGC differentiation.
Maurer KA, Kowalchuk A, Shoja-Taheri F, Brown NL., Free PMC Article | 12/1/2018 |
| Authors conclude that the Neurog2 gene is expressed and active prior to birth, but also exerts an influence on postnatal retinal neuron differentiation. | Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.
Kowalchuk AM, Maurer KA, Shoja-Taheri F, Brown NL., Free PMC Article | 10/20/2018 |
| Neurog2 and Ascl1 altered the expression of Ikaros and Foxg1. | Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex.
Dennis DJ, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, Han S, Kovach C, Gruenig N, Kurrasch DM, Dyck RH, Schuurmans C., Free PMC Article | 05/5/2018 |
| data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 in NEUROG2-driven astrocytic reprogramming. | CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons.
Aravantinou-Fatorou K, Ortega F, Chroni-Tzartou D, Antoniou N, Poulopoulou C, Politis PK, Berninger B, Matsas R, Thomaidou D., Free PMC Article | 06/11/2016 |
| Findings suggest the strict spatio-temporal expression of Notch effector genes plays an important role during hippocampal neurogenesis and suggests that Notch1, Hes1 and Ngn2 were regulated by changing some specific CpG sites of their promoters. | Exploring the potential relationship between Notch pathway genes expression and their promoter methylation in mice hippocampal neurogenesis.
Zhang Z, Gao F, Kang X, Li J, Zhang L, Dong W, Jin Z, Li F, Gao N, Cai X, Yang S, Zhang J, Ren X, Yang X. | 01/16/2016 |
| IFN-gamma inhibits neuronal differentiation of neural progenitor cells by negatively regulating the expression of Neurog2 via the JAK/STAT1 pathway. | Interferon-gamma inhibits the neuronal differentiation of neural progenitor cells by inhibiting the expression of Neurogenin2 via the JAK/STAT1 pathway.
Ahn J, Lee J, Kim S. | 12/19/2015 |
| In mid-embryonic neocortical walls, expression of Neurog2-d4Venus mostly overlapped with that of Neurog2 protein, with a slightly (1 h) delayed onset. | Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain.
Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T., Free PMC Article | 02/21/2015 |
| APP-stimulated neuronal differentiation of NSPCs is mediated by Ngn2 | Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.
Bolós M, Hu Y, Young KM, Foa L, Small DH., Free PMC Article | 01/24/2015 |
| Notch signaling controls the overall tempo of retinogenesis through Atoh7 and Neurog2, by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave | Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.
Maurer KA, Riesenberg AN, Brown NL., Free PMC Article | 10/18/2014 |
| Neurog1 and Neurog2 have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons | Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex.
Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C., Free PMC Article | 03/8/2014 |
| Neurog2 functions as a transcriptional activator to initiate the expression of several genetic off-switches, each of which repress distinct gene expression programs during neocortical development. | Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.
Kovach C, Dixit R, Li S, Mattar P, Wilkinson G, Elsen GE, Kurrasch DM, Hevner RF, Schuurmans C. | 03/1/2014 |
| Sustained vs. oscillating expressions of Ngn2, Dll1 and Hes1: a model of neural differentiation of embryonic telencephalon. | Sustained vs. oscillating expressions of Ngn2, Dll1 and Hes1: a model of neural differentiation of embryonic telencephalon.
Barton A, Fendrik AJ. | 11/2/2013 |