| Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase beta-Subunit. | Hypercapnia Induces Inositol-Requiring Enzyme 1α-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase β-Subunit.
Kryvenko V, Wessendorf M, Tello K, Herold S, Morty RE, Seeger W, Vadász I. | 12/25/2021 |
| the transepithelial potential difference (TEP) across the retinal pigment epithelial (RPE) depends on the expression of ATP1B1 and this regulates the secretion of PEDF by RPE cells and so may regulate the onset of retinal disease. Increasing the expression of PEDF using an applied EF to replenish a disease or age-reduced TEP may offer a new way of preventing or reversing retinal dysfunction. | Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.
Cao L, Liu J, Pu J, Milne G, Chen M, Xu H, Shipley A, Forrester JV, McCaig CD, Lois N., Free PMC Article | 12/14/2019 |
| Functional selection and assembly of NKA subunit isoforms occurs in the cochlear stria vascularis lateral wall, which is disrupted and dysregulated with age. | Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea.
Ding B, Walton JP, Zhu X, Frisina RD., Free PMC Article | 09/21/2019 |
| Data show that differentially expressed in chondrocytes 1 protein (DEC1) and circadian locomoter output cycles kaput protein (CLOCK) bound to E-boxes in the beta1 subunit of the Na(+)/K(+)-ATPase (ATP1B1) promoter and suppressed the expression of ATP1B1. | Dec1 and CLOCK Regulate Na(+)/K(+)-ATPase β1 Subunit Expression and Blood Pressure.
Nakashima A, Kawamoto T, Noshiro M, Ueno T, Doi S, Honda K, Maruhashi T, Noma K, Honma S, Masaki T, Higashi Y, Kato Y. | 04/13/2019 |
| FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model. | FXYD5 (dysadherin) may mediate metastatic progression through regulation of the β-Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model.
Lubarski-Gotliv I, Dey K, Kuznetsov Y, Kalchenco V, Asher C, Garty H. | 08/5/2017 |
| Activities of AE1 and the sodium pump are coregulated in kidney. | Physical and functional links between anion exchanger-1 and sodium pump.
Su Y, Al-Lamki RS, Blake-Palmer KG, Best A, Golder ZJ, Zhou A, Karet Frankl FE., Free PMC Article | 04/25/2015 |
| Atp1b1 was highly expressed in luminal epithelium during peri-implantation and upregulated by progesterone. | Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period.
Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. | 12/21/2013 |
| Inhibition of the Atp1b1 isoenzyme of the sodium potassium exchanging ATPase by 8-methoxycoumestrol is reported. | Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.
Potter T, Hauck C, Pôças ES, Diedrichs H, Adam C, Reuter H, Wittwer T, Wahlers T, da Silva AJ, Costa PR, Noël F, Müller-Ehmsen J. | 01/21/2010 |
| Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart. | Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.
Barwe SP, Jordan MC, Skay A, Inge L, Rajasekaran SA, Wolle D, Johnson CL, Neco P, Fang K, Rozengurt N, Goldhaber JI, Roos KP, Rajasekaran AK., Free PMC Article | 01/21/2010 |
| These data suggest that CLN3 is involved in the regulation of plasma membrane fodrin cytoskeleton and consequently, the plasma membrane association of Na(+), K(+) ATPase. | Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.
Uusi-Rauva K, Luiro K, Tanhuanpää K, Kopra O, Martín-Vasallo P, Kyttälä A, Jalanko A. | 01/21/2010 |
| Beta(1) is the sole expressed beta-subunit in the diaphragm throughout development, and in the hindlimb muscles at birth. | Na,K-ATPase alpha- and beta-isoform expression in developing skeletal muscles: alpha(2) correlates with t-tubule formation.
Cougnon MH, Moseley AE, Radzyukevich TL, Lingrel JB, Heiny JA. | 01/21/2010 |
| the beta1 subunit of the Na/K-ATPase is required for blastocyst formation and also for maintaining a normal Na/K-ATPase distribution and localization of tight junction-associated polypeptides during preimplantation development | Na/K-ATPase beta1 subunit expression is required for blastocyst formation and normal assembly of trophectoderm tight junction-associated proteins.
Madan P, Rose K, Watson AJ. | 01/21/2010 |