| Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways. | Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.
Piñol RA, Mogul AS, Hadley CK, Saha A, Li C, Škop V, Province HS, Xiao C, Gavrilova O, Krashes MJ, Reitman ML., Free PMC Article | 04/2/2022 |
| The effects of housing density on mouse thermal physiology depend on sex and ambient temperature. | The effects of housing density on mouse thermal physiology depend on sex and ambient temperature.
Škop V, Xiao C, Liu N, Gavrilova O, Reitman ML., Free PMC Article | 03/26/2022 |
| Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain. | Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain.
Mogul AS, Hadley CK, Province HS, Pauli J, Gavrilova O, Xiao C, Palmiter RD, Piñol RA, Reitman ML., Free PMC Article | 09/18/2021 |
| BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice. | BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice.
Xiao C, Liu N, Province H, Piñol RA, Gavrilova O, Reitman ML., Free PMC Article | 07/3/2021 |
| Brs3 expression is a useful marker for delineating energy metabolism regulatory circuitry. | Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.
Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML., Free PMC Article | 05/18/2019 |
| Brs3 expression in glutamatergic neurons is both necessary and sufficient for full Brs3 function in energy metabolism. In these experiments, no function was identified for Brs3 in GABAergic neurons. | Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.
Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML., Free PMC Article | 01/19/2019 |
| Data suggest that the failure to detect an existing endogenous bombesin-like receptor 3 (BRS-3) ligand in the parabiotic mice could be due to limited cross-circulation and a ligand's short half-life. | Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice.
Lateef DM, Xiao C, Reitman ML., Free PMC Article | 06/28/2016 |
| Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. | RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.
Hong SK, Yang SY, Yin SH, Yang KX. | 08/16/2014 |
| Data from knockout mice suggest that Brs3 involvement in regulation of body temperature is via a central mechanism, upstream of sympathetic efferent pathways to stimulate brown adipose tissue. | Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.
Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML., Free PMC Article | 05/31/2014 |
| This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the mouse brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides. | Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system.
Zhang L, Parks GS, Wang Z, Wang L, Lew M, Civelli O. | 08/31/2013 |
| Data suggest that the bombesin receptor subtype-3 agonist indirectly inhibited orexin neurons through GABAergic input and directly activated orexin neurons. | Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways.
Furutani N, Hondo M, Tsujino N, Sakurai T. | 01/1/2011 |
| Hyperphagia is a major factor leading to increased body weight and hyperinsulinemia in BRS-3 KO mice. | Factors contributing to obesity in bombesin receptor subtype-3-deficient mice.
Ladenheim EE, Hamilton NL, Behles RR, Bi S, Hampton LL, Battey JF, Moran TH., Free PMC Article | 01/21/2010 |
| BRS-3-deficient mice remained longer in the open arms of the maze. Analyses of risk assessment behavior revealed that BRS-3-deficient mice exhibited increased 'stretched attend posture' behavior in both the L-D box and elevated plus maze tests. | Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice.
Yamada K, Santo-Yamada Y, Wada E, Wada K. | 01/21/2010 |
| BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs | Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung.
Shan L, Emanuel RL, Dewald D, Torday JS, Asokanathan N, Wada K, Wada E, Sunday ME. | 01/21/2010 |
| BRS-3 gene deletion upsets the mechanism by which leptin decreases the expression of MCH-R. | Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3.
Maekawa F, Quah HM, Tanaka K, Ohki-Hamazaki H. | 01/21/2010 |