| The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling. | The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling.
Annamneedi A, Del Angel M, Gundelfinger ED, Stork O, Çalışkan G., Free PMC Article | 09/11/2021 |
| Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals. | Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.
Ducrot C, Bourque MJ, Delmas CVL, Racine AS, Guadarrama Bello D, Delignat-Lavaud B, Domenic Lycas M, Fallon A, Michaud-Tardif C, Burke Nanni S, Herborg F, Gether U, Nanci A, Takahashi H, Parent M, Trudeau LE. | 08/14/2021 |
| BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy. | BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy.
Montenegro-Venegas C, Annamneedi A, Hoffmann-Conaway S, Gundelfinger ED, Garner CC., Free PMC Article | 07/31/2021 |
| Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes. | Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes.
Ryl M, Urbasik A, Gierke K, Babai N, Joachimsthaler A, Feigenspan A, Frischknecht R, Stallwitz N, Fejtová A, Kremers J, von Wittgenstein J, Brandstätter JH. | 07/31/2021 |
| Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice. | Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, Garner CC, Montenegro-Venegas C., Free PMC Article | 03/20/2021 |
| Bassoon inhibits proteasome activity via interaction with PSMB4. | Bassoon inhibits proteasome activity via interaction with PSMB4.
Montenegro-Venegas C, Fienko S, Anni D, Pina-Fernández E, Frischknecht R, Fejtova A., Free PMC Article | 03/6/2021 |
| The expression of Bassoon in excitatory forebrain neurons is required for the normal maturation of the dentate gyrus and important for spatial and contextual memory. | Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance.
Annamneedi A, Caliskan G, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O., Free PMC Article | 07/27/2019 |
| Piccolo puncta sandwiched Bassoon puncta and aligned in a Piccolo-Bassoon-Piccolo structure in adult neuromuscular junctions (NMJs). P/Q-type voltage-gated calcium channel (VGCC) puncta colocalized with Bassoon puncta. The P/Q-type VGCC and Bassoon protein levels decreased significantly in NMJs from aged mouse. In contrast, the Piccolo levels in NMJs from aged mice were comparable to levels in adult mice. | Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.
Nishimune H, Badawi Y, Mori S, Shigemoto K., Free PMC Article | 04/21/2018 |
| These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites. | Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein.
Davydova D, Marini C, King C, Klueva J, Bischof F, Romorini S, Montenegro-Venegas C, Heine M, Schneider R, Schröder MS, Altrock WD, Henneberger C, Rusakov DA, Gundelfinger ED, Fejtova A. | 06/7/2014 |
| Authors conclude that bassoon promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse. | Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T., Free PMC Article | 04/26/2014 |
| phosphorylation-induced 14-3-3 binding to Bassoon modulates its anchoring to the presynaptic cytomatrix | Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
Schröder MS, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A., Free PMC Article | 09/21/2013 |
| proper assembly of ribbon synapses depend on Bassoon | Evidence for synergistic and complementary roles of Bassoon and darkness in organizing the ribbon synapse.
Spiwoks-Becker I, Lamberti R, Tom Dieck S, Spessert R. | 08/31/2013 |
| a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis. | Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.
Waites CL, Leal-Ortiz SA, Okerlund N, Dalke H, Fejtova A, Altrock WD, Gundelfinger ED, Garner CC., Free PMC Article | 05/25/2013 |
| This studyy demonistrated that reduced bassoon expression or complete lack of full-length bassoon impaired sound encoding to a similar extent, which is consistent with the comparable reduction of the readily releasable vesicle pool | Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
Jing Z, Rutherford MA, Takago H, Frank T, Fejtova A, Khimich D, Moser T, Strenzke N., Free PMC Article | 04/27/2013 |
| hippocampal overgrowth in Bassoon-mutant mice arises from a dysregulation of neurogenesis and apoptosis that might be associated with unbalanced BDNF levels. | Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels.
Heyden A, Ionescu MC, Romorini S, Kracht B, Ghiglieri V, Calabresi P, Seidenbecher C, Angenstein F, Gundelfinger ED. | 02/25/2012 |
| Results support the notion that Bassoon is important for organizing the presynaptic active zone during the postnatal maturation of glutamatergic synapses. | Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon.
Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E, Mulle C., Free PMC Article | 10/23/2010 |
| Our findings reveal a novel function of Bassoon in the early formation and delivery of precursor spheres to nascent ribbon synaptic sites | Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis.
Regus-Leidig H, tom Dieck S, Brandstätter JH. | 07/12/2010 |
| piccolo and bassoon play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release. | Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.
Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC., Free PMC Article | 05/10/2010 |
| true cone-selective type 1 and 2 OFF cone bipolar cells did not show sprouting in the Bassoon mouse mutant | Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods.
Haverkamp S, Specht D, Majumdar S, Zaidi NF, Brandstätter JH, Wasco W, Wässle H, Tom Dieck S. | 01/21/2010 |
| altered neuronal activation pattern in the cortex is reflected not only in defined cytoarchitectural anomalies but also in metabolic disturbances in the glutamine-glutamate and N-acetyl aspartate metabolism in Bsn mutants | Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study.
Angenstein F, Hilfert L, Zuschratter W, Altrock WD, Niessen HG, Gundelfinger ED. | 01/21/2010 |
| Deficiency of Bassoon, a major component of the photoreceptor ribbon, results in impaired photoreceptor synaptic transmission, abnormal dendritic branching of neurons postsynaptic to photoreceptors, and the formation of ectopic synapses. | The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina.
Dick O, tom Dieck S, Altrock WD, Ammermüller J, Weiler R, Garner CC, Gundelfinger ED, Brandstätter JH. | 01/21/2010 |
| the absence of the functional presynaptic protein Bassoon causes disturbance in the formation of normal basal cortical activation patterns and thereby in the functional cortical architecture | Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice.
Angenstein F, Niessen HG, Goldschmidt J, Lison H, Altrock WD, Gundelfinger ED, Scheich H. | 01/21/2010 |
| Loss of Bassoon in Bsn mutant mice causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. | Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C, Fässler R, Richter K, Boeckers TM, Potschka H, Brandt C, Löscher W, Grimberg D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU, Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED. | 01/21/2010 |