| High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients. | High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients.
von Koskull A, Hagström J, Haglund C, Kaprio T, Böckelman C. | 04/30/2024 |
| CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis. | CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis.
Shen L, Dang J, Liu S, Xian B, Deng Y, Qu D. | 08/13/2022 |
| FRMD6 has tumor suppressor functions in prostate cancer. | FRMD6 has tumor suppressor functions in prostate cancer.
Haldrup J, Strand SH, Cieza-Borrella C, Jakobsson ME, Riedel M, Norgaard M, Hedensted S, Dagnaes-Hansen F, Ulhoi BP, Eeles R, Borre M, Olsen JV, Thomsen M, Kote-Jarai Z, Sorensen KD. | 07/31/2021 |
| Results indicate that metastasis associated 1 family member 2 (MTA2) represses a cohort of genes including FERM domain containing 6 protein (FRMD6) that are critically involved in the growth and mobility of hepatocellular carcinoma (HCC). | MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.
Guan C, Chang Z, Gu X, Liu R. | 07/4/2020 |
| concluded that lncRNA FRMD6-AS2 repressed uterine corpus endometrial carcinoma, at least in part, by increasing FRMD6 | The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma.
Wang J, Li Z, Wang X, Ding Y, Li N. | 02/29/2020 |
| a novel function of FRMD6 in inhibiting human GBM growth and progression and uncover a novel mechanism by which FRMD6 exerts its anti-GBM activity. | FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases.
Xu Y, Wang K, Yu Q., Free PMC Article | 02/24/2018 |
| we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra and/or FRMD6, in mammary epithelial cells. | CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P., Free PMC Article | 10/28/2017 |
| Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. | Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.
Hong MG, Reynolds CA, Feldman AL, Kallin M, Lambert JC, Amouyel P, Ingelsson E, Pedersen NL, Prince JA., Free PMC Article | 06/9/2012 |
| Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway | Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway.
Visser-Grieve S, Hao Y, Yang X. | 04/28/2012 |
| in mammalian cells willin influences Hippo signaling activity by activating the core Hippo pathway kinase cassette | Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.
Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ. | 03/3/2012 |
| Results describe a new FERM domain-containing protein called Willin. | A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.
Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S. | 01/21/2010 |