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    Anxa2 annexin A2 [ Mus musculus (house mouse) ]

    Gene ID: 12306, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.

    Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
    Nakamura Y, Ito MA, Hoshino Y, Matsuoka I, Okada T, Okada Y, Nakanishi T.

    03/29/2024
    Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1.

    Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1.
    He J, Hou X, Wu J, Wang K, Qi X, Wei Z, Sun Y, Wang C, Yao H, Liu K., Free PMC Article

    03/15/2024
    ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.

    ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.
    Koh M, Lim H, Jin H, Kim M, Hong Y, Hwang YK, Woo Y, Kim ES, Kim SY, Kim KM, Lim HK, Jung J, Kang S, Park B, Lee HB, Han W, Lee MS, Moon A.,

    03/11/2024
    Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-kappaB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.

    Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.
    Tian X, Yang W, Jiang W, Zhang Z, Liu J, Tu H., Free PMC Article

    02/27/2024
    Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.

    Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.
    Gounou C, Rouyer L, Siegfried G, Harté E, Bouvet F, d'Agata L, Darbo E, Lefeuvre M, Derieppe MA, Bouton L, Mélane M, Chapeau D, Martineau J, Prouzet-Mauleon V, Tan S, Souleyreau W, Saltel F, Argoul F, Khatib AM, Brisson AR, Iggo R, Bouter A., Free PMC Article

    12/20/2023
    RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13.

    RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13.
    Zhuang S, Lu W, Shen L, Huang Z, Zhang X, Zhang Y.

    12/15/2023
    Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

    Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.
    Ito S, Kuromiya K, Sekai M, Sako H, Sai K, Morikawa R, Mukai Y, Ida Y, Anzai M, Ishikawa S, Kozawa K, Shirai T, Tanimura N, Sugie K, Ikenouchi J, Ogawa M, Naguro I, Ichijo H, Fujita Y., Free PMC Article

    11/3/2023
    Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.

    Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.
    Zhang M, Li X, Cui X, Li R, Ma Z, Gao X.

    10/28/2023
    ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Beta3.

    ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.
    Zhang Y, Wang Y, Li J, Li C, Liu W, Long X, Wang Z, Zhao R, Ge J, Shi B.

    10/24/2023
    Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.

    Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.
    Dai Y, Wei T, Huang Y, Bei Y, Lin H, Shen Z, Yu L, Yang M, Xu H, He W, Lin Z, Dai H., Free PMC Article

    09/28/2023
    Blockade of Annexin A2 Prevents Early Microvasculopathy in Murine Models of Diabetic Retinopathy.

    Blockade of Annexin A2 Prevents Early Microvasculopathy in Murine Models of Diabetic Retinopathy.
    Dallacasagrande V, Liu W, Almeida D, Luo M, Hajjar KA., Free PMC Article

    05/8/2023
    Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.

    Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
    Lin H, Li W, Shen Z, Bei Y, Wei T, Yu Z, Dai Y, Dai H.

    12/10/2022
    Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-kappaB signaling pathway.

    Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway.
    Tang G, Yu C, Xiang K, Gao M, Liu Z, Yang B, Yang M, Zhao S.

    08/27/2022
    The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression.

    The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression.
    Wang G, Duan J, Pu G, Ye C, Li Y, Xiu W, Xu J, Liu B, Zhu Y, Wang C.

    05/21/2022
    STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/beta-catenin pathway via binding to Annexin A2 in osteoporosis.

    STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.
    Xu Y, Bao X, Chen X, Wu P, Chen S, Zhang B, Ma J, Xu G, Ma D., Free PMC Article

    04/30/2022
    Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis.

    Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis.
    Tezuka K, Suzuki M, Sato R, Kawarada S, Terasaki T, Uchida Y.

    04/30/2022
    The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.

    The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.
    Yin G, Yang C, Wu G, Yu X, Tian Q, Chen D, Cao B, Zhao L, Xu N, Jin S, Zhang W, Wang J., Free PMC Article

    11/6/2021
    FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/beta-catenin signaling by binding with ANXA2.

    FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/β-catenin signaling by binding with ANXA2.
    Xiang L, Zheng J, Zhang M, Ai T, Cai B., Free PMC Article

    07/3/2021
    Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.

    Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
    Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y., Free PMC Article

    03/20/2021
    Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.

    Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.
    Su Z, Chang Q, Drelich A, Shelite T, Judy B, Liu Y, Xiao J, Zhou C, He X, Jin Y, Saito T, Tang S, Soong L, Wakamiya M, Fang X, Bukreyev A, Ksiazek T, Russell WK, Gong B., Free PMC Article

    08/22/2020
    Deletion of ANXA2 impeded rickettsial attachment to endothelial cells in vitro and blocked rickettsial adherence to the blood vessel luminal surface in vivo.

    A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study.
    He X, Zhang W, Chang Q, Su Z, Gong D, Zhou Y, Xiao J, Drelich A, Liu Y, Popov V, Zhao X, Wakamiya M, Gaitas A, Lu F, Gong B., Free PMC Article

    07/11/2020
    Compared with wild-type mice, the expression of cerebral endothelial junctional proteins was reduced in E15.5 and adult ANXA2 knockout mice, along with increased leakage of small molecule tracers.

    Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability.
    Li W, Chen Z, Yuan J, Yu Z, Cheng C, Zhao Q, Huang L, Hajjar KA, Chen Z, Lo EH, Dai H, Wang X., Free PMC Article

    05/23/2020
    these results suggested that AnxA2 deficiency results in exacerbated early neurovascular pro-inflammation, which leads to a worse long-term neurologic outcome after Traumatic brain injury.

    Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice.
    Liu N, Jiang Y, Chung JY, Li Y, Yu Z, Kim JW, Lok JM, Whalen MJ, Wang X., Free PMC Article

    04/18/2020
    ANXA2 can contribute to bleomycin-induced pulmonary fibrosis by mediating inflammatory response.

    Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.
    Lei Y, Wang K, Li X, Li Y, Feng X, Zhou J, Zhang Z, Huang C, Zhang T.

    02/1/2020
    Anxa2 is highly expressed in insulin resistance and silencing Anxa2 inhibits insulin resistance triggered by obesity.

    Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway.
    Wang Y, Cheng YS, Yin XQ, Yu G, Jia BL.

    11/16/2019
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