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    Calb2 calbindin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12308, updated on 30-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Phosphatase and Tensin Homolog Inhibition in Proteolipid Protein 1-Expressing Cells Stimulates Neurogenesis and Gliogenesis in the Postnatal Enteric Nervous System.

    Phosphatase and Tensin Homolog Inhibition in Proteolipid Protein 1-Expressing Cells Stimulates Neurogenesis and Gliogenesis in the Postnatal Enteric Nervous System.
    Woods C, Flockton AR, Belkind-Gerson J., Free PMC Article

    04/2/2024
    Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.

    Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.
    Zaidi SAH, Xu Z, Lemtalsi T, Sandow P, Athota S, Liu F, Haigh S, Huo Y, Narayanan SP, Fulton DJR, Rojas MA, Fouda AY, Caldwell RW, Caldwell RB., Free PMC Article

    11/2/2023
    Rabies virus infection is associated with variations in calbindin D-28K and calretinin mRNA expression levels in mouse brain tissue.

    Rabies virus infection is associated with variations in calbindin D-28K and calretinin mRNA expression levels in mouse brain tissue.
    Korie GC, Sallau AB, Kanu B, Kia GSN, Kwaga JKP., Free PMC Article

    05/9/2023
    Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.

    Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.
    Su M, Liu J, Yu B, Zhou K, Sun C, Yang M, Zhao C., Free PMC Article

    01/22/2022
    Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease.

    Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease.
    Giesers NK, Wirths O., Free PMC Article

    09/18/2021
    Calbindin expression in adult vestibular epithelia.

    Calbindin expression in adult vestibular epithelia.
    Prins TJ, Myers ZA, Saldate JJ, Hoffman LF.

    09/11/2021
    Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.

    Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
    Shi A, Petrache AL, Shi J, Ali AB., Free PMC Article

    06/12/2021
    The results suggest that dorsal horn circuits that involve excitatory calretinin neurons are important for the generation and amplification of pain and identify these interneurons as a future analgesic target.

    Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn.
    Smith KM, Browne TJ, Davis OC, Coyle A, Boyle KA, Watanabe M, Dickinson SA, Iredale JA, Gradwell MA, Jobling P, Callister RJ, Dayas CV, Hughes DI, Graham BA., Free PMC Article

    05/9/2020
    given the importance of the neuronal network of PreFrontal Cortwx in central control of emotion and cognition and in the pathology of mental diseases, Calretinin(+)-GABAergic neuron-mediated feed-forward and -backward modulation within PFC would differentially modulate the downstream limbic activity and subsequently shape the cognitive and emotional behavior.

    Calretinin(+)-neurons-mediated GABAergic inhibition in mouse prefrontal cortex.
    Saffari R, Grotefeld K, Kravchenko M, Zhang M, Zhang W.

    04/4/2020
    calretinin as a Ca(2+)-binding protein participates in the regulation of steroidogenesis via the PLC-Ca(2+)-PKC pathway in Leydig cells

    Calretinin Participates in Regulating Steroidogenesis by PLC-Ca(2+)-PKC Pathway in Leydig Cells.
    Xu W, Zhu Q, Liu S, Dai X, Zhang B, Gao C, Gao L, Liu J, Cui Y., Free PMC Article

    10/12/2019
    The findings of this study suggest that there are at least three distinct classes of CR+ interneurons in the striatum of the rat and the mouse.

    Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.
    Garas FN, Kormann E, Shah RS, Vinciati F, Smith Y, Magill PJ, Sharott A., Free PMC Article

    06/15/2019
    The expression of calretinin was identified in spermatozoa.

    Characterization and potential roles of calretinin in rodent spermatozoa.
    Dressen C, Schwaller B, Vegh G, Leleux F, Gall D, Lebrun P, Lybaert P.

    05/11/2019
    Results show that calretinin is differentially expressed, being present in the majority of substance P-, neurokinin B (NKB), gastrin-releasing peptide (GRP) expressing cells, but not in the neurotensin or dynorphin cells; inhibitory Cre-expressing cells in a Tac1(Cre) knock-in mouse are calretinin-immunoreactive.

    Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord.
    Gutierrez-Mecinas M, Davis O, Polgár E, Shahzad M, Navarro-Batista K, Furuta T, Watanabe M, Hughes DI, Todd AJ., Free PMC Article

    03/23/2019
    In this study we demonstrate dynamic changes in the number of calretinin- (CR) and neuropeptide Y-expressing (NPY) interneurons in the motor cortex of the familial hSOD1(G93A) ALS mouse model, suggesting their potential involvement in motor neuron circuitry defects.

    Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1(G93A) mouse model of ALS.
    Clark RM, Blizzard CA, Young KM, King AE, Dickson TC., Free PMC Article

    11/10/2018
    This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the Superior Olivary Complex of the circling mouse on postnatal day 16.

    Immunohistochemical Localization of Calbindin D28k, Parvalbumin, and Calretinin in the Superior Olivary Complex of Circling Mice.
    Lee JK, Maskey D, Kim MJ.

    07/28/2018
    Absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration.

    Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration.
    Blum W, Pecze L, Felley-Bosco E, Schwaller B., Free PMC Article

    07/16/2016
    CR may play an important role in the development of the paralemniscal pathway.

    Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex.
    Liu J, Liu B, Zhang X, Yu B, Guan W, Wang K, Yang Y, Gong Y, Wu X, Yanagawa Y, Wu S, Zhao C., Free PMC Article

    11/14/2015
    Melatonin favors calretinin-positive neurons in the dentate gyrus of young mice but hippocampal neurogenesis and plasma levels of melatonin decrease during aging.

    Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice.
    Ramírez-Rodríguez G, Gómez-Sánchez A, Ortíz-López L.

    08/22/2015
    EF-hand Ca(2+) buffers regulate presynaptic IHC function for metabolically efficient sound coding.

    EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
    Pangršič T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T., Free PMC Article

    05/9/2015
    distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development

    Expression of calcium-binding proteins in layer 1 reelin-immunoreactive cells during rat and mouse neocortical development.
    Martinez-Galan JR, Moncho-Bogani J, Caminos E., Free PMC Article

    03/1/2014
    calretinin can serve as a marker of the intermediate olfactory receptor neurons.

    Calretinin is expressed in the intermediate cells during olfactory receptor neuron development.
    Wei H, Lang MF, Jiang X.

    08/31/2013
    Expression of calretinin in various hippocampal subfields is significantly lower in the circling mouse compared to wild-type.

    Changes in the distribution of calbindin D28-k, parvalbumin, and calretinin in the hippocampus of the circling mouse.
    Maskey D, Pradhan J, Oh CK, Kim MJ.

    05/4/2013
    an unexpected role for CR in directly modulating effectors such as Ca(v)2.1, which may have major consequences for Ca(2+) signaling and neuronal excitability.

    Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the α12.1 subunit.
    Christel CJ, Schaer R, Wang S, Henzi T, Kreiner L, Grabs D, Schwaller B, Lee A., Free PMC Article

    02/23/2013
    Calretinin, a member of the EF-hand family of calcium-binding proteins, is preferentially associated with mutated huntingtin (Htt), although it also interacts with wild-type Htt.

    Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
    Dong G, Gross K, Qiao F, Ferguson J, Callegari EA, Rezvani K, Zhang D, Gloeckner CJ, Ueffing M, Wang H.

    12/22/2012
    The decrease or absence of calretinin in granule cells of circling mice may perturb Purkinje cell function in vivo, which may affect normal behavior.

    Immunohistochemical localization of calbindin D28-k, parvalbumin, and calretinin in the cerebellar cortex of the circling mouse.
    Maskey D, Pradhan J, Kim HJ, Park KS, Ahn SC, Kim MJ.

    06/4/2011
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