| Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. | Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis.
Tonosaki M, Fujimori A, Yaoi T, Itoh K., Free PMC Article | 12/4/2023 |
| ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11. | ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Fang Q, Li Q, Qi Y, Pan Z, Feng T, Xin W. | 06/16/2023 |
| The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly. | The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly.
Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M., Free PMC Article | 04/12/2023 |
| Loss of abnormal spindle-like, microcephaly-associated (Aspm) disrupts female folliculogenesis in mice during maturation and aging. | Loss of abnormal spindle-like, microcephaly-associated (Aspm) disrupts female folliculogenesis in mice during maturation and aging.
Mori M, Tando S, Ogi H, Tonosaki M, Yaoi T, Fujimori A, Itoh K. | 09/3/2022 |
| A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons. | A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons.
Garrett L, Chang YJ, Niedermeier KM, Heermann T, Enard W, Fuchs H, Gailus-Durner V, Angelis MH, Huttner WB, Wurst W, Hölter SM., Free PMC Article | 08/7/2021 |
| in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity. | ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
Gai M, Bianchi FT, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AM, Annaratone L, Sapino A, Bergo A, Landsberger N, Bond J, Huttner WB, Di Cunto F., Free PMC Article | 07/29/2017 |
| Aspm and Wdr62 interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone. | Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.
Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA., Free PMC Article | 07/29/2017 |
| Interaction between ASPM and the Cdk2/Cyclin E complex regulated the Cyclin activity by modulating its ubiquitination and localization into the nucleus. | ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.
Capecchi MR, Pozner A., Free PMC Article | 07/2/2016 |
| Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. | Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice.
Williams SE, Garcia I, Crowther AJ, Li S, Stewart A, Liu H, Lough KJ, O'Neill S, Veleta K, Oyarzabal EA, Merrill JR, Shih YY, Gershon TR., Free PMC Article | 03/5/2016 |
| Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure teratogens. | Disruption of Aspm causes microcephaly with abnormal neuronal differentiation.
Fujimori A, Itoh K, Goto S, Hirakawa H, Wang B, Kokubo T, Kito S, Tsukamoto S, Fushiki S. | 03/7/2015 |
| ASPM plays a critical role in meiotic spindle assembly and meiotic progression in mouse oocytes. | The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes.
Xu XL, Ma W, Zhu YB, Wang C, Wang BY, An N, An L, Liu Y, Wu ZH, Tian JH., Free PMC Article | 05/11/2013 |
| AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons | In vivo fate analysis reveals the multipotent and self-renewal features of embryonic AspM expressing cells.
Marinaro C, Butti E, Bergamaschi A, Papale A, Furlan R, Comi G, Martino G, Muzio L., Free PMC Article | 12/3/2011 |
| knockdown of Aspm results in decreased Wnt-mediated transcription | ASPM regulates Wnt signaling pathway activity in the developing brain.
Buchman JJ, Durak O, Tsai LH., Free PMC Article | 11/5/2011 |
| truncated Aspm proteins cause a massive loss of germ cells, resulting in a severe reduction in testis and ovary size accompanied by reduced fertility | Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.
Pulvers JN, Bryk J, Fish JL, Wilsch-Bräuninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, Nitsch R, Tóth A, Enard W, Pääbo S, Huttner WB., Free PMC Article | 11/6/2010 |
| NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway | Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway.
Wu SC, Chang SC, Wu HY, Liao PJ, Chang MF., Free PMC Article | 01/21/2010 |
| tissue distribution of Calmbp1 in fetal and adult mice | Murine calmodulin binding protein 1 (Calmbp1): tissue-specific expression during development and in adult tissues.
Lüers GH, Michels M, Schwaab U, Franz T. | 01/21/2010 |
| evolutionary selection of specific segments of the ASPM sequence strongly relates to differences in cerebral cortical size | Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.
Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, Yoon YH, Collura R, Ruvolo M, Barrett JC, Woods CG, Walsh CA, Jurka J, Larionov V., Free PMC Article | 01/21/2010 |
| Aspm is crucial for maintaining a cleavage plane orientation that allows symmetric, proliferative divisions of neuroepithelial cells during brain develo | Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.
Fish JL, Kosodo Y, Enard W, Pääbo S, Huttner WB., Free PMC Article | 01/21/2010 |