| Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms. | Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms.
Holl K, Chatain N, Krapp S, Baumeister J, Maié T, Schmitz S, Scheufen A, Brock N, Koschmieder S, Moreno-Andrés D., Free PMC Article | 02/7/2024 |
| Neuroprotective role of calreticulin after spinal cord injury in mice. | Neuroprotective role of calreticulin after spinal cord injury in mice.
Melnikova A, Ishii H, Tamatani T, Hattori T, Takarada-Iemata M, Hori O. | 08/28/2023 |
| The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. | The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
Sen Santara S, Lee DJ, Crespo Â, Hu JJ, Walker C, Ma X, Zhang Y, Chowdhury S, Meza-Sosa KF, Lewandrowski M, Zhang H, Rowe M, McClelland A, Wu H, Junqueira C, Lieberman J., Free PMC Article | 04/20/2023 |
| Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression. | Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J., Free PMC Article | 06/25/2022 |
| The ATF6beta-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity. | The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.
Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O., Free PMC Article | 11/13/2021 |
| Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development. | Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.
Serin N, Dihazi GH, Tayyeb A, Lenz C, Müller GA, Zeisberg M, Dihazi H., Free PMC Article | 06/26/2021 |
| Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice. | Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice.
Shide K, Kameda T, Kamiunten A, Ozono Y, Tahira Y, Yokomizo-Nakano T, Kubota S, Ono M, Ikeda K, Sekine M, Akizuki K, Nakamura K, Hidaka T, Kubuki Y, Iwakiri H, Hasuike S, Nagata K, Sashida G, Shimoda K., Free PMC Article | 02/20/2021 |
| Calreticulin regulates a switch between osteoblast and chondrocyte lineages derived from murine embryonic stem cells. | Calreticulin regulates a switch between osteoblast and chondrocyte lineages derived from murine embryonic stem cells.
Pilquil C, Alvandi Z, Opas M., Free PMC Article | 12/26/2020 |
| Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN. | Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN.
Benlabiod C, Cacemiro MDC, Nédélec A, Edmond V, Muller D, Rameau P, Touchard L, Gonin P, Constantinescu SN, Raslova H, Villeval JL, Vainchenker W, Plo I, Marty C., Free PMC Article | 10/24/2020 |
| Calr protein expression significantly decreases with age in mesenteric arteries. Calcium signals and vasodilation were significantly impaired in aged endothelial cells Calr knockdown mice. | Endothelial calreticulin deletion impairs endothelial function in aged mice.
Biwer LA, Askew-Page HR, Hong K, Milstein J, Johnstone SR, Macal E, Good ME, Bagher P, Sonkusare SK, Isakson BE., Free PMC Article | 07/18/2020 |
| Lack of calreticulin translocation onto mouse melanoma cell membrane prevents the stimulation of an effective immunogenic cell death response in vivo. | Ecto-Calreticulin is essential for an efficient immunogenic cell death stimulation in mouse melanoma.
Giglio P, Gagliardi M, Bernardini R, Mattei M, Cotella D, Santoro C, Piacentini M, Corazzari M. | 01/25/2020 |
| autocrine CTRP9 of cardiomyocyte origin protects against myocardial ischemia/reperfusion injury via CRT association | Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis.
Zhao D, Feng P, Sun Y, Qin Z, Zhang Z, Tan Y, Gao E, Lau WB, Ma X, Yang J, Yu S, Xu X, Yi D, Yi W., Free PMC Article | 11/9/2019 |
| calreticulin modulation may eliminate the toxic gain of function associated with aggregation of ZAAT in lung and liver, thus providing a potential new therapeutic approach to the treatment of AATD-related liver disease. | Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α(1)-antitrypsin disposal.
Khodayari N, Oshins R, Alli AA, Tuna KM, Holliday LS, Krotova K, Brantly M., Free PMC Article | 10/19/2019 |
| Induction of endoplasmic reticulum stress due to loss of calreticulin led to enhanced caveolin-1 mediated endocytosis. | Endoplasmic reticulum stress enhances endocytosis in calreticulin deficient cells.
Massaeli H, Viswanathan D, Pillai DG, Mesaeli N. | 09/14/2019 |
| Endoplasmic reticulum Ca(2+) status and loss of calreticulin important determinants of the basal sensitivity of the sterol sensing mechanism . | Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis.
Wang WA, Liu WX, Durnaoglu S, Lee SK, Lian J, Lehner R, Ahnn J, Agellon LB, Michalak M., Free PMC Article | 02/9/2019 |
| Homozygous CALR(del/del) mice developed extreme thrombocytosis accompanied by features of Myelofibrosis, including leukocytosis, reduced hematocrit, splenomegaly, and increased bone marrow reticulin. this provides a powerful model for dissection the pathogenesis of CALR-mutant essential thrombocythemia and primary myelofibrosis. | Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.
Li J, Prins D, Park HJ, Grinfeld J, Gonzalez-Arias C, Loughran S, Dovey OM, Klampfl T, Bennett C, Hamilton TL, Pask DC, Sneade R, Williams M, Aungier J, Ghevaert C, Vassiliou GS, Kent DG, Green AR. | 02/9/2019 |
| Calr specifically at myoendothelial junction at holes in the internal elastic lamina may act in a non-ER dependent manner to regulate arteriolar heterocellular communication and blood pressure. | Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function.
Biwer LA, Good ME, Hong K, Patel RK, Agrawal N, Looft-Wilson R, Sonkusare SK, Isakson BE., Free PMC Article | 02/2/2019 |
| role for NR5A2 and its SUMOylation on the transcriptional regulation of the calreticulin gene in a model of renal fibrosis | Nuclear receptor NR5A2 is involved in the calreticulin gene regulation during renal fibrosis.
Arvaniti E, Vakrakou A, Kaltezioti V, Stergiopoulos A, Prakoura N, Politis PK, Charonis A. | 02/2/2019 |
| Calreticulin is required for TGF-beta mediated epithelial-mesenchymal transition and cardiomyogenesis from mESCs. | Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells.
Karimzadeh F, Opas M., Free PMC Article | 02/24/2018 |
| CALR mutation analysis can thus be a useful additional diagnostic tool to achieve an accurate diagnosis for patients with ET who lack JAK2V617F and MPLW515 mutations | Novel CALR somatic mutations in essential thrombocythaemia.
Riera L, Osella-Abate S, Benevolo G, Beggiato E, Ferrero S, Pich A, Francia di Celle P. | 02/17/2018 |
| CRT inhibition significantly blunted APN's anti-oxidative action (evidenced by gp91(phox) expression and superoxide generation). However, CRT inhibition did not attenuate AMPK phosphorylation by APN administration in NCM. Therefore, these novel findings strongly indicate that APN exerts cardioprotective effects against I/R injury partially via CRT mediated anti-apoptotic and anti-oxidative actions. | Adiponectin exerts cardioprotection against ischemia/reperfusion injury partially via calreticulin mediated anti-apoptotic and anti-oxidative actions.
Sun Y, Zhao D, Yang Y, Gao C, Zhang X, Ma Z, Jiang S, Zhao L, Chen W, Ren K, Yi W, Gao F. | 02/17/2018 |
| we show that the homologous mouse CALR del52, ins5 and del61 mutants also activate thrombopoietin receptor signaling via JAK-STAT pathway | Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.
Balligand T, Achouri Y, Pecquet C, Chachoua I, Nivarthi H, Marty C, Vainchenker W, Plo I, Kralovics R, Constantinescu SN. | 02/10/2018 |
| study provides a model showing that the C-terminal of mutant CALR activated JAK-STAT signaling specifically downstream of MPL and may have a central role in CALR-induced myeloproliferative neoplasms | Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib.
Shide K, Kameda T, Yamaji T, Sekine M, Inada N, Kamiunten A, Akizuki K, Nakamura K, Hidaka T, Kubuki Y, Shimoda H, Kitanaka A, Honda A, Sawaguchi A, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hasuike S, Yamamoto S, Nagata K, Shimoda K., Free PMC Article | 09/16/2017 |
| the results of this investigation provide the first molecular insights into the phospholipid binding site of calreticulin as a key anchor point for the cell surface expression of calreticulin on apoptotic cells | The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis.
Wijeyesakere SJ, Bedi SK, Huynh D, Raghavan M., Free PMC Article | 08/12/2017 |
| a profound impairment in calreticulin function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin within the endoplasmic reticulum. | Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells.
Lum R, Ahmad S, Hong SJ, Chapman DC, Kozlov G, Williams DB., Free PMC Article | 05/20/2017 |