| The ER chaperone calnexin controls mitochondrial positioning and respiration. | The ER chaperone calnexin controls mitochondrial positioning and respiration.
Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T. | 11/6/2021 |
| The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis. | The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis.
Paskevicius T, Jung J, Pujol M, Eggleton P, Qin W, Robinson A, Gutowski N, Holley J, Smallwood M, Newcombe J, Zochodne D, Chen XZ, Tang J, Kraus A, Michalak M, Agellon LB. | 04/24/2021 |
| EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin. | EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
Mizoguchi I, Ohashi M, Hasegawa H, Chiba Y, Orii N, Inoue S, Kawana C, Xu M, Sudo K, Fujita K, Kuroda M, Hashimoto SI, Matsushima K, Yoshimoto T., Free PMC Article | 02/20/2021 |
| Study discovered that calnexin is highly abundant in human brain endothelial cells of multiple sclerosis (MS) patients. Conversely, mice lacking calnexin exhibited resistance to experimental autoimmune encephalomyelitis induction, no evidence of immune cell infiltration into the CNS. These findings identify a link between calnexin expression in CNS endothelial cells and neuroinflammation. | Calnexin is necessary for T cell transmigration into the central nervous system.
Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, Newcombe J, Dudek E, Paul AM, Zochodne D, Kraus A, Power C, Agellon LB, Michalak M., Free PMC Article | 12/7/2019 |
| CNX has a specific role in cardiomyocyte viability and Ca(2+) cycling through its effects on endoplasmic reticulum stress, apoptosis and Ca(2+) channel expression. | Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis.
Bousette N, Abbasi C, Chis R, Gramolini AO. | 01/25/2014 |
| Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity. | Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2).
Arribas-González E, Alonso-Torres P, Aragón C, López-Corcuera B., Free PMC Article | 11/30/2013 |
| calnexin and ERp57, but not calreticulin, play an important role in the biology of peripheral myelin proteins PMP22 and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies | Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
Jung J, Coe H, Michalak M. | 12/31/2011 |
| Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice | Enhanced clathrin-dependent endocytosis in the absence of calnexin.
Li HD, Liu WX, Michalak M., Free PMC Article | 11/5/2011 |
| Data show that the E351 mutation led to slightly enhanced ERp57 binding to calnexin, whereas W428 greatly enhanced binding of ERp57 to calnexin. | Mutational analysis of calnexin.
Groenendyk J, Dabrowska M, Michalak M. | 07/30/2011 |
| Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm. | Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
Han C, Park I, Lee B, Jin S, Choi H, Kwon JT, Kwon YI, Kim DH, Park ZY, Cho C. | 04/16/2011 |
| endoplasmic reticulum stress has effects on group VIA phospholipase A2 in beta cells that include tyrosine phosphorylation and increased association with calnexin | Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, Turk J., Free PMC Article | 11/27/2010 |
| Calnexin deficiency leads to dysmyelination | Calnexin deficiency leads to dysmyelination.
Kraus A, Groenendyk J, Bedard K, Baldwin TA, Krause KH, Dubois-Dauphin M, Dyck J, Rosenbaum EE, Korngut L, Colley NJ, Gosgnach S, Zochodne D, Todd K, Agellon LB, Michalak M., Free PMC Article | 07/5/2010 |
| Data give novel evidence that CyCAP regulates the post-translational modification of tissue transglutaminase through its colocalization with calnexin in endoplasmic reticulum. | Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.
Kong W, Lin BW, Li S, Longaker MT, Lorenz HP. | 03/15/2010 |
| ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity | ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity.
Zhang Y, Kozlov G, Pocanschi CL, Brockmeier U, Ireland BS, Maattanen P, Howe C, Elliott T, Gehring K, Williams DB., Free PMC Article | 01/21/2010 |
| Mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx. | Calnexin is not essential for mammalian rod opsin biogenesis.
Kosmaoglou M, Cheetham ME., Free PMC Article | 01/21/2010 |
| Cnx (-/-) cells have significantly increased proteasomal activity, which may play a role in the adaptive mechanisms addressing the acute endoplasmic reticulum stress observed in the absence of calnexin. | Endoplasmic reticulum stress in the absence of calnexin.
Coe H, Bedard K, Groenendyk J, Jung J, Michalak M., Free PMC Article | 01/21/2010 |
| Calnexin might stimulate the productive folding of WT CF transmembrane conductance regulator (CFTR), but not DeltaF508 CFTR, which has folding defects. | Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR.
Okiyoneda T, Niibori A, Harada K, Kohno T, Michalak M, Duszyk M, Wada I, Ikawa M, Shuto T, Suico MA, Kai H. | 01/21/2010 |
| caspase-3 or caspase-7 cleaves calnexin, whose cleaved product leads to the attenuation of apoptosis | Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosis.
Takizawa T, Tatematsu C, Watanabe K, Kato K, Nakanishi Y. | 01/21/2010 |
| Association with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases. | Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases.
Dickson KM, Bergeron JJ, Shames I, Colby J, Nguyen DT, Chevet E, Thomas DY, Snipes GJ., Free PMC Article | 01/21/2010 |
| UGT1 activity might be required for a structural maturation needed for substrate dissociation from calnexin and export from the ER. | Substrate-specific requirements for UGT1-dependent release from calnexin.
Soldà T, Galli C, Kaufman RJ, Molinari M. | 01/21/2010 |
| Calnexin is required for myelinated motor neuron function and postnatal survival in mice | Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression.
Denzel A, Molinari M, Trigueros C, Martin JE, Velmurgan S, Brown S, Stamp G, Owen MJ., Free PMC Article | 01/21/2010 |
| In mice, a calnexin-glycan interaction may be required to stabilize the weak association of MHC class I heavy chain with beta 2-microglobulin in the endoplasmic reticulum until peptide is bound. | Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum.
Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, Kadavil K, Lencer WI, Blumberg RS. | 01/21/2010 |
| Data show that in calreticulin-deficient cells, calnexin-substrate association is severely reduced, leading to accumulation of unfolded proteins and a triggering of the unfolded protein response. | Compromised calnexin function in calreticulin-deficient cells.
Knee R, Ahsan I, Mesaeli N, Kaufman RJ, Michalak M. | 01/21/2010 |
| Data show that oculocutaneous albinism soluble tyrosinase is an endoplasmic reticulum-associated degradation substrate that, unlike other albino tyrosinases, associates with calreticulin and BiP/GRP78, but not calnexin. | Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.
Popescu CI, Paduraru C, Dwek RA, Petrescu SM. | 01/21/2010 |