| Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts. | Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
Du X, Zang C, Wang Q., Free PMC Article | 03/13/2024 |
| Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2. | Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
Tsao CH, Hsieh WC, Yang RY, Lo YH, Tu TJ, Ke LY, Zouboulis CC, Liu FT. | 07/16/2022 |
| Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells. | Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.
Niwa T, Akaike Y, Watanabe K, Chibazakura T. | 09/11/2021 |
| Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte. | Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte.
Li J, Dong F, Ouyang YC, Sun QY, Qian WP. | 03/20/2021 |
| Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry. | Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry.
Radonova L, Pauerova T, Jansova D, Danadova J, Skultety M, Kubelka M, Anger M., Free PMC Article | 01/9/2021 |
| wild type control, 14-3-3 is detected in both cytosolic and nuclear fractions whereas it is restricted to the cytoplasm in mutant testes. This differential distribution of 14-3-3 may contribute to the induction of apoptosis in Ccna1-deficient spermatocytes | Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins.
Panigrahi SK, Manterola M, Wolgemuth DJ., Free PMC Article | 09/9/2017 |
| cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction | Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.
Miftakhova R, Hedblom A, Batkiewicz L, Anagnosaki L, Zhang Y, Sjölander A, Wingren AG, Wolgemuth DJ, Persson JL., Free PMC Article | 04/23/2016 |
| Neither overexpression nor loss of cyclin A1 significantly altered leukemogenesis in PML-RARalpha-knockin mice. | A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.
Bäumer N, Bäumer S, Haak M, Koschmieder S, Schönig K, Berdel WE, Müller-Tidow C., Free PMC Article | 03/26/2016 |
| With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells | Cyclin A1 is expressed in mouse ovary.
Wei H, Li Y, Zhao C, Jiang X, Chen H, Lang MF, Sun J., Free PMC Article | 01/3/2015 |
| Sp1 and possibly GATA1 bind concomitantly to the Ccna1 promoter and suppress its activity in vivo. | Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1.
Panigrahi SK, Vasileva A, Wolgemuth DJ., Free PMC Article | 04/27/2013 |
| CIZ1 interacts with germ-cell-specific cyclin A1. | Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells.
Greaves EA, Copeland NA, Coverley D, Ainscough JF. | 12/8/2012 |
| REVIEW. Some cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions; meiosis-specific function has been shown for cyclin A1. | Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells.
Wolgemuth DJ., Free PMC Article | 01/21/2010 |
| Ccna1-deficiency in spermatogenesis is associated with defects in DNA double-strand break repair, which is enhanced by loss of p53. | Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis.
Baumer N, Sandstede ML, Diederichs S, Kohler G, Readhead C, Ji P, Zhang F, Bulk E, Gromoll J, Berdel WE, Serve H, Muller-Tidow C. | 01/21/2010 |
| decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice. | Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage.
Kawamata M, Nishimori K. | 01/21/2010 |
| Analysis of Ccna1 transgene expression indicated that sequences within -1.3 kilobases (kb) of the cyclin A1 putative transcriptional start site were sufficient to direct transgene expression uniquely to late spermatocytes. | Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function.
Lele KM, Wolgemuth DJ. | 01/21/2010 |
| cyclin A1 has a critical role in the pericentromeric region in late diplotene of meiosis, perhaps in assembly or function of the passenger protein complex | Cyclin A1-deficient mice lack histone H3 serine 10 phosphorylation and exhibit altered aurora B dynamics in late prophase of male meiosis.
Nickerson HD, Joshi A, Wolgemuth DJ., Free PMC Article | 01/21/2010 |
| Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 | Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.
Pilkinton M, Sandoval R, Song J, Ness SA, Colamonici OR. | 01/21/2010 |