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    Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 12482, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment

    Converting Lymphoma Cells into Potent Antigen-Presenting Cells for Interferon-Induced Tumor Regression.
    Liao J, Luan Y, Ren Z, Liu X, Xue D, Xu H, Sun Z, Yang K, Peng H, Fu YX., Free PMC Article

    Galectin-1 has a role in driving lymphoma CD20 immunotherapy resistance in a mouse model

    Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms.
    Lykken JM, Horikawa M, Minard-Colin V, Kamata M, Miyagaki T, Poe JC, Tedder TF., Free PMC Article

    Results indicate that an antigen-specific B cell response towards intracellular pathogens can be generated during anti-CD20 depletion therapy.

    Characterization of the B cell response to Leishmania infection after anti-CD20 B cell depletion.
    Bockenstedt MM, Boggiatto PM, Jones DE., Free PMC Article

    this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity.

    Reduced T-dependent humoral immunity in CD20-deficient mice.
    Morsy DE, Sanyal R, Zaiss AK, Deo R, Muruve DA, Deans JP.

    CD20 is required for store-operated calcium entry in C2C12 myoblasts.

    Expression of CD20 reveals a new store-operated calcium entry modulator in skeletal muscle.
    Parolini D, Cassinelli L, Razini P, Sitzia C, Tonna N, Erratico S, Colleoni F, Angeloni V, Maffioli E, Farini A, Maciotta S, Porretti L, Belicchi M, Bianco F, Tedeschi G, Meregalli M, Torrente Y.

    immunization of mice with the CD20 extracellular domain-6 using Freund's or QS-21 adjuvants was shown to exert significant biological effects in vivo with the pronounced depletion of splenic B cells.

    A CD20 tandem-epitope immunogen elicits antibody in mice that binds murine cell surface CD20 and depletes splenic B cells in vivo.
    Oscherwitz J, Gribbin TE, Cease KB.

    type I CD20 antibody cytotoxicity critically depends on Fc receptor ITAM signaling

    In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.
    de Haij S, Jansen JH, Boross P, Beurskens FJ, Bakema JE, Bos DL, Martens A, Verbeek JS, Parren PW, van de Winkel JG, Leusen JH.

    CD20 deficiency in humans results in impaired T cell-independent antibody responses.

    CD20 deficiency in humans results in impaired T cell-independent antibody responses.
    Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA., Free PMC Article

    involvement of CD20 in calcium influx

    CD20 homo-oligomers physically associate with the B cell antigen receptor. Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins.
    Polyak MJ, Li H, Shariat N, Deans JP.

    In mice treated with anti-CD20 mAb, development of arthritis was significantly reduced in comparison to control mAb-treated mice

    Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity.
    Hamel K, Doodes P, Cao Y, Wang Y, Martinson J, Dunn R, Kehry MR, Farkas B, Finnegan A.

    review of structure, function, tissue and cell distribution

    Macardle PJ, Nicholson IC.

    expression in bacterial cells; isolation and biophysical and structural studies

    Isolation and characterization of the B-cell marker CD20.
    Ernst JA, Li H, Kim HS, Nakamura GR, Yansura DG, Vandlen RL.

    Anti-CD20 antibodies rapidly depleted the vast majority of circulating and tissue B cells in an isotype-restricted manner dependent on effector cell Fc receptor expression.

    The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
    Uchida J, Hamaguchi Y, Oliver JA, Ravetch JV, Poe JC, Haas KM, Tedder TF., Free PMC Article

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