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    Cd8a CD8 antigen, alpha chain [ Mus musculus (house mouse) ]

    Gene ID: 12525, updated on 21-Oct-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    IL-4Ralpha signaling by CD8alpha(+) dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8(+) T cell responses.

    IL-4Rα signaling by CD8α<sup>+</sup> dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8<sup>+</sup> T cell responses.
    Wu X, Brombacher F, Chroneos ZC, Norbury CC, Gowda DC., Free PMC Article

    08/7/2021
    Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells.

    Constitutive CD8 expression drives innate CD8<sup>+</sup> T-cell differentiation via induction of iNKT2 cells.
    Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I., Free PMC Article

    03/13/2021
    Intestinal CD8alphaalpha IELs derived from two distinct thymic precursors have staggered ontogeny.

    Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
    Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA., Free PMC Article

    03/6/2021
    CD8alpha-deficient conventional dendritic cells control Vbeta T-cell immunity in response to Staphylococcus aureus infection in mice.

    CD8α<sup>-</sup> conventional dendritic cells control Vβ T-cell immunity in response to Staphylococcus aureus infection in mice.
    Zhang W, Xu L, Zhang X, Xu J, Jin JO., Free PMC Article

    08/1/2020
    results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells

    Concomitant Disruption of <i>CD4</i> and <i>CD8</i> Genes Facilitates the Development of Double Negative αβ TCR<sup>+</sup> Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen.
    Chowdhary VR, Krogman A, Tilahun AY, Alexander MP, David CS, Rajagopalan G., Free PMC Article

    09/23/2017
    Depletion of Depletion of medullary thymic epithelial cells (mTECs) and CD8 antigen alpha chain (CD8alpha+) dendritic cells (DCs) leads to overt autoimmunity.

    Medullary thymic epithelial cells and CD8α<sup>+</sup> dendritic cells coordinately regulate central tolerance but CD8α<sup>+</sup> cells are dispensable for thymic regulatory T cell production.
    Herbin O, Bonito AJ, Jeong S, Weinstein EG, Rahman AH, Xiong H, Merad M, Alexandropoulos K., Free PMC Article

    06/3/2017
    The generation of cancer-specific CD8(+) CD69(+)-expressing lymphocytes that inhibit colon cancer growth has been described.

    Generation of cancer-specific CD8(+) CD69(+) cells inhibits colon cancer growth.
    Lan B, Zhang J, Lu D, Li W.

    08/20/2016
    TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

    T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.
    Sharma A, Berga-Bolaños R, Sen JM., Free PMC Article

    04/30/2016
    Batf3 deficiency is not critical for the generation of CD8alpha dendritic cells

    Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.
    Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H., Free PMC Article

    11/21/2015
    Lck-CD8 interaction is required for initial CD8 recruitment.

    Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
    Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR., Free PMC Article

    10/17/2015
    Brd1-mediated Hbo1 activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.

    Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
    Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A., Free PMC Article

    10/3/2015
    Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes.

    Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.
    Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, Devisscher L, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

    09/26/2015
    Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.

    A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
    Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W.

    06/20/2015
    Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment.

    GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
    Wang X, Sumida H, Cyster JG., Free PMC Article

    04/25/2015
    CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.

    CD8α dendritic cells drive establishment of HSV-1 latency.
    Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H.

    01/24/2015
    Data show that targeting nanoparticles containing alpha-galactosylceramide (alpha-GalCer) and Ag to CD8alpha(+) dendritic cells promotes potent antitumor responses, both in prophylactic and in therapeutic settings.

    Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responses.
    Macho-Fernandez E, Cruz LJ, Ghinnagow R, Fontaine J, Bialecki E, Frisch B, Trottein F, Faveeuw C.

    10/4/2014
    Downregulation of CD8 during type 2 olarization of murine CD8(+) effector T cells is associated with CpG methylation of several regions of the Cd8a locus.

    Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.
    Harland KL, Day EB, Apte SH, Russ BE, Doherty PC, Turner SJ, Kelso A.

    09/27/2014
    Data indicate that CD8alpha knockout mice reconstituted with CD8(+) T cells restored the sensitivity to Ang II.

    The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure.
    Ma F, Feng J, Zhang C, Li Y, Qi G, Li H, Wu Y, Fu Y, Zhao Y, Chen H, Du J, Tang H.

    06/14/2014
    CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.

    cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
    Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC.

    03/29/2014
    Therefore, EXOs derived from natural CD4(+)25(+) and CD8(+)25(+) Tr cells may become an alternative for immunotherapy of autoimmune diseases.

    Natural CD8⁺25⁺ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma.
    Xie Y, Zhang X, Zhao T, Li W, Xiang J.

    11/16/2013
    Data indicate that CD8low cells survive long term in vivo.

    Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.
    Olver S, Apte SH, Baz A, Kelso A, Kienzle N.

    07/6/2013
    A previously undescribed pathway by which CD8alpha+ Dendritic cells emerge independent of Id2, Nfil3, and Batf3, but dependent on Irf8.

    CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.
    Seillet C, Jackson JT, Markey KA, Brady HJ, Hill GR, Macdonald KP, Nutt SL, Belz GT.

    05/4/2013
    Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium.

    Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium.
    Li G, Smithey MJ, Rudd BD, Nikolich-Žugich J.

    04/20/2013
    During establishment of viral persistence, the cellular subset with the most prevalent expression of IL-10 was CD8alpha(-)CD4(+) dendritic cells (DCs), which produced IL-10 with increasing kinetics until 9 d postinfection.

    Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection.
    Ng CT, Oldstone MB.

    12/22/2012
    CD8 marks a population of lung airway-derived dendritic cells with distinct migratory and maturation responses that likely contribute differentially to the immune response depending on the infecting pathogen

    CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.
    Beauchamp NM, Yammani RD, Alexander-Miller MA.

    12/8/2012
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