| A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4[+], CD8[+], Caspase-3 and NF-kappaB in mice. | A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4(+), CD8(+), Caspase-3 and NF-κB in mice.
Aboelsoued D, Toaleb NI, Ibrahim S, Shaapan RM, Megeed KNA., Free PMC Article | 11/1/2023 |
| The CD8alpha-PILRalpha interaction maintains CD8(+) T cell quiescence. | The CD8α-PILRα interaction maintains CD8(+) T cell quiescence.
Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. | 06/11/2022 |
| Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10. | Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10.
Goodall KJ, Nguyen A, Andrews DM, Sullivan LC., Free PMC Article | 11/27/2021 |
| Positron emission tomography imaging with (89)Zr-labeled anti-CD8 cys-diabody reveals CD8(+) cell infiltration during oncolytic virus therapy in a glioma murine model. | Positron emission tomography imaging with (89)Zr-labeled anti-CD8 cys-diabody reveals CD8(+) cell infiltration during oncolytic virus therapy in a glioma murine model.
Kasten BB, Houson HA, Coleman JM, Leavenworth JW, Markert JM, Wu AM, Salazar F, Tavaré R, Massicano AVF, Gillespie GY, Lapi SE, Warram JM, Sorace AG., Free PMC Article | 11/6/2021 |
| IL-4Ralpha signaling by CD8alpha(+) dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8(+) T cell responses. | IL-4Rα signaling by CD8α(+) dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8(+) T cell responses.
Wu X, Brombacher F, Chroneos ZC, Norbury CC, Gowda DC., Free PMC Article | 08/7/2021 |
| Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells. | Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells.
Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I., Free PMC Article | 03/13/2021 |
| Intestinal CD8alphaalpha IELs derived from two distinct thymic precursors have staggered ontogeny. | Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA., Free PMC Article | 03/6/2021 |
| CD8alpha-deficient conventional dendritic cells control Vbeta T-cell immunity in response to Staphylococcus aureus infection in mice. | CD8α(-) conventional dendritic cells control Vβ T-cell immunity in response to Staphylococcus aureus infection in mice.
Zhang W, Xu L, Zhang X, Xu J, Jin JO., Free PMC Article | 08/1/2020 |
| results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells | Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR(+) Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen.
Chowdhary VR, Krogman A, Tilahun AY, Alexander MP, David CS, Rajagopalan G., Free PMC Article | 09/23/2017 |
| Depletion of Depletion of medullary thymic epithelial cells (mTECs) and CD8 antigen alpha chain (CD8alpha+) dendritic cells (DCs) leads to overt autoimmunity. | Medullary thymic epithelial cells and CD8α(+) dendritic cells coordinately regulate central tolerance but CD8α(+) cells are dispensable for thymic regulatory T cell production.
Herbin O, Bonito AJ, Jeong S, Weinstein EG, Rahman AH, Xiong H, Merad M, Alexandropoulos K., Free PMC Article | 06/3/2017 |
| The generation of cancer-specific CD8(+) CD69(+)-expressing lymphocytes that inhibit colon cancer growth has been described. | Generation of cancer-specific CD8(+) CD69(+) cells inhibits colon cancer growth.
Lan B, Zhang J, Lu D, Li W. | 08/20/2016 |
| TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells. | T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.
Sharma A, Berga-Bolaños R, Sen JM., Free PMC Article | 04/30/2016 |
| Batf3 deficiency is not critical for the generation of CD8alpha dendritic cells | Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.
Mott KR, Maazi H, Allen SJ, Zandian M, Matundan H, Ghiasi YN, Sharifi BG, Underhill D, Akbari O, Ghiasi H., Free PMC Article | 11/21/2015 |
| Lck-CD8 interaction is required for initial CD8 recruitment. | Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR., Free PMC Article | 10/17/2015 |
| Brd1-mediated Hbo1 activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers. | Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A., Free PMC Article | 10/3/2015 |
| Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes. | Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.
Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, Devisscher L, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G., Free PMC Article | 09/26/2015 |
| Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex. | A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W. | 06/20/2015 |
| Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment. | GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
Wang X, Sumida H, Cyster JG., Free PMC Article | 04/25/2015 |
| CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences. | CD8α dendritic cells drive establishment of HSV-1 latency.
Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H., Free PMC Article | 01/24/2015 |
| Data show that targeting nanoparticles containing alpha-galactosylceramide (alpha-GalCer) and Ag to CD8alpha(+) dendritic cells promotes potent antitumor responses, both in prophylactic and in therapeutic settings. | Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responses.
Macho-Fernandez E, Cruz LJ, Ghinnagow R, Fontaine J, Bialecki E, Frisch B, Trottein F, Faveeuw C. | 10/4/2014 |
| Downregulation of CD8 during type 2 olarization of murine CD8(+) effector T cells is associated with CpG methylation of several regions of the Cd8a locus. | Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.
Harland KL, Day EB, Apte SH, Russ BE, Doherty PC, Turner SJ, Kelso A., Free PMC Article | 09/27/2014 |
| Data indicate that CD8alpha knockout mice reconstituted with CD8(+) T cells restored the sensitivity to Ang II. | The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure.
Ma F, Feng J, Zhang C, Li Y, Qi G, Li H, Wu Y, Fu Y, Zhao Y, Chen H, Du J, Tang H. | 06/14/2014 |
| CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a. | cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC., Free PMC Article | 03/29/2014 |
| Therefore, EXOs derived from natural CD4(+)25(+) and CD8(+)25(+) Tr cells may become an alternative for immunotherapy of autoimmune diseases. | Natural CD8⁺25⁺ regulatory T cell-secreted exosomes capable of suppressing cytotoxic T lymphocyte-mediated immunity against B16 melanoma.
Xie Y, Zhang X, Zhao T, Li W, Xiang J. | 11/16/2013 |
| Data indicate that CD8low cells survive long term in vivo. | Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.
Olver S, Apte SH, Baz A, Kelso A, Kienzle N., Free PMC Article | 07/6/2013 |