| Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells. | Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
Nair TS, Kakaraparthi BN, Yang L, Lu L, Thomas TB, Morris AC, Kommareddi P, Kanicki A, Carey TE. | 03/5/2022 |
| Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding sitedagger. | Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site†.
Wang H, Hong X, Kinsey WH., Free PMC Article | 01/8/2022 |
| CD9 induces cellular senescence and aggravates atherosclerotic plaque formation. | CD9 induces cellular senescence and aggravates atherosclerotic plaque formation.
Cho JH, Kim EC, Son Y, Lee DW, Park YS, Choi JH, Cho KH, Kwon KS, Kim JR., Free PMC Article | 09/25/2021 |
| Unveiling a novel function of CD9 in surface compartmentalization of oocytes. | Unveiling a novel function of CD9 in surface compartmentalization of oocytes.
Inoue N, Saito T, Wada I. | 03/27/2021 |
| we also revealed that the CD9-HuR exosomes could enrich the functional miRNA inhibitor or CRISPR/dCas9 when the RNAs were engineered to have the AU rich elements. | In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9.
Li Z, Zhou X, Wei M, Gao X, Zhao L, Shi R, Sun W, Duan Y, Yang G, Yuan L. | 11/30/2019 |
| CD9 and CD81 might coordinately prevent senescence and inflammation, partly by maintaining SIRT1 expression. Altogether, CD9/CD81 DKO mice represent a novel model for both COPD and accelerated senescence. | Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.
Jin Y, Takeda Y, Kondo Y, Tripathi LP, Kang S, Takeshita H, Kuhara H, Maeda Y, Higashiguchi M, Miyake K, Morimura O, Koba T, Hayama Y, Koyama S, Nakanishi K, Iwasaki T, Tetsumoto S, Tsujino K, Kuroyama M, Iwahori K, Hirata H, Takimoto T, Suzuki M, Nagatomo I, Sugimoto K, Fujii Y, Kida H, Mizuguchi K, Ito M, Kijima T, Rakugi H, Mekada E, Tachibana I, Kumanogoh A., Free PMC Article | 09/28/2019 |
| The spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations, until a CD9-rich platform is nucleated on which fusion immediately takes place. Within 2-5 min after fusion, most of the CD9 leaves the egg for the external aqueous medium. | Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal.
Ravaux B, Favier S, Perez E, Gourier C. | 09/21/2019 |
| The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area. | CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization.
Frolikova M, Manaskova-Postlerova P, Cerny J, Jankovicova J, Simonik O, Pohlova A, Secova P, Antalikova J, Dvorakova-Hortova K., Free PMC Article | 09/15/2018 |
| The Cd9(-/-) and Cd9(-/-) Cd81(-/-) deletions are associated with a decreased microvilli density on the MII oocyte surface. Microvilli thickness is significantly increased whatever the deleted tetraspanin gene be. Only Cd9 deletion clearly disturbs the vesicular traffic, increasing the number of clathrin and exosome vesicles. | Tetraspanins and Mouse Oocyte Microvilli Related to Fertilizing Ability.
Benammar A, Ziyyat A, Lefèvre B, Wolf JP. | 03/31/2018 |
| CD9 regulates the T cell-stimulatory capacity of granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent bone marrow-derived Dendritic Cells (BMDCs), without affecting antigen presentation by fms-like tyrosine kinase 3 ligand (Flt3L)-dependent BMDCs. | CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells.
Rocha-Perugini V, Martínez Del Hoyo G, González-Granado JM, Ramírez-Huesca M, Zorita V, Rubinstein E, Boucheix C, Sánchez-Madrid F., Free PMC Article | 09/23/2017 |
| DPP4:CD9:TTSP as the protein complexes are necessary for early efficient MERS-coronavirus entry. | The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases.
Earnest JT, Hantak MP, Li K, McCray PB Jr, Perlman S, Gallagher T., Free PMC Article | 09/23/2017 |
| Our results indicate that the suppression of cartilage degradation in CD9(-/-) could be in part related to an increase in the expression of the two main cartilage extracellular matrix proteins aggrecan and type II collagen. | The role of tetraspanin CD9 in osteoarthritis using three different mouse models.
Sumiyoshi N, Ishitobi H, Miyaki S, Miyado K, Adachi N, Ochi M. | 01/28/2017 |
| upregulation may play an important role in podocyte morphology, adhesion, and migration | Mechanical stress enhances CD9 expression in cultured podocytes.
Blumenthal A, Giebel J, Warsow G, Li L, Ummanni R, Schordan S, Schordan E, Klemm P, Gretz N, Endlich K, Endlich N. | 05/23/2015 |
| Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties. | Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties.
Singh A, Lester C, Drapp R, Hu DZ, Glimcher LH, Jones D., Free PMC Article | 03/21/2015 |
| Data indicate that anti-inflammatory effects of statins are CD9-dependent. | Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.
Jin Y, Tachibana I, Takeda Y, He P, Kang S, Suzuki M, Kuhara H, Tetsumoto S, Tsujino K, Minami T, Iwasaki T, Nakanishi K, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Ito M, Saya H, Kumanogoh A., Free PMC Article | 07/5/2014 |
| study demonstrates ablation of Cd9 had no detectable effect on de novo primary proatate tumour onset, but did significantly increase metastasis to the liver but not the lungs | Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.
Copeland BT, Bowman MJ, Boucheix C, Ashman LK. | 11/16/2013 |
| In vitro myotubes lacking CD9P-1 or both CD9 and CD81 fuse with a higher frequency than normal myotubes | Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81.
Charrin S, Latil M, Soave S, Polesskaya A, Chrétien F, Boucheix C, Rubinstein E. | 10/26/2013 |
| chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family | Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
Hálová I, Dráberová L, Bambousková M, Machyna M, Stegurová L, Smrž D, Dráber P., Free PMC Article | 06/1/2013 |
| tetraspanin CD9 modulates molecular organization of integrins in lymphatic endothelial cells, thereby supporting several functions required for lymphangiogenesis | Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A., Free PMC Article | 04/6/2013 |
| Tetraspanin family member CD9 plays an important role in sperm-egg fusion. | Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility.
Inoue N, Nishikawa T, Ikawa M, Okabe M. | 10/13/2012 |
| present study demonstrates that CD9 associates with CD36 on the macrophage surface and may participate in macrophage signaling in response to oxidized LDL | CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein.
Huang W, Febbraio M, Silverstein RL., Free PMC Article | 05/26/2012 |
| Results show that SSCs are the most concentrated in CD9(+)EPCAM(low/-) population and also suggest that EPCAM plays an important role in progenitor cell amplification in the mouse spermatogenic system. | Dynamic changes in EPCAM expression during spermatogonial stem cell differentiation in the mouse testis.
Kanatsu-Shinohara M, Takashima S, Ishii K, Shinohara T., Free PMC Article | 02/18/2012 |
| Our study demonstrated the importance of CD9 in wound re-epithelialization, linking this molecule directly to basement membrane formation and epidermal migration through participating in the regulation of the JNK/MMP-9 pathway. | CD9 is critical for cutaneous wound healing through JNK signaling.
Zhang J, Dong J, Gu H, Yu S, Zhang X, Gou Y, Xu W, Burd A, Huang L, Miyado K, Huang Y, Chan HC. | 02/11/2012 |
| propose that sperm-egg fusion is a direct consequence of CD9 controlled sperm-egg adhesion properties. CD9 generates adhesion sites responsible for the strongest of the observed gamete interaction. | CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilization.
Jégou A, Ziyyat A, Barraud-Lange V, Perez E, Wolf JP, Pincet F, Gourier C., Free PMC Article | 09/10/2011 |
| knockout mice display abnormal adult angiogenesis | alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells.
Cailleteau L, Estrach S, Thyss R, Boyer L, Doye A, Domange B, Johnsson N, Rubinstein E, Boucheix C, Ebrahimian T, Silvestre JS, Lemichez E, Meneguzzi G, Mettouchi A. | 11/27/2010 |