| Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction. | Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction.
Simmers MD, Hudson KM, Baptissart M, Cowley M., Free PMC Article | 11/30/2023 |
| p57[Kip2] acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation. | p57(Kip2) acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation.
Creff J, Nowosad A, Prel A, Pizzoccaro A, Aguirrebengoa M, Duquesnes N, Callot C, Jungas T, Dozier C, Besson A. | 10/13/2023 |
| p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms. | p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
Takahashi K, Amano H, Urano T, Li M, Oki M, Aoki K, Amizuka N, Nakayama KI, Nakayama K, Udagawa N, Higashi N., Free PMC Article | 02/18/2023 |
| IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells. | IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
Lozano-Ureña A, Lázaro-Carot L, Jiménez-Villalba E, Montalbán-Loro R, Mateos-White I, Duart-Abadía P, Martínez-Gurrea I, Nakayama KI, Fariñas I, Kirstein M, Gil-Sanz C, Ferrón SR., Free PMC Article | 02/10/2023 |
| p57(Kip2) imposes the reserve stem cell state of gastric chief cells. | p57(Kip2) imposes the reserve stem cell state of gastric chief cells.
Lee JH, Kim S, Han S, Min J, Caldwell B, Bamford AD, Rocha ASB, Park J, Lee S, Wu SS, Lee H, Fink J, Pilat-Carotta S, Kim J, Josserand M, Szep-Bakonyi R, An Y, Ju YS, Philpott A, Simons BD, Stange DE, Choi E, Koo BK, Kim JK., Free PMC Article | 05/21/2022 |
| Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development. | Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y., Free PMC Article | 11/21/2020 |
| Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms. | Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.
Laukoter S, Beattie R, Pauler FM, Amberg N, Nakayama KI, Hippenmeyer S., Free PMC Article | 04/4/2020 |
| The results reveal a novel Shh-Foxd1-Cdkn1c regulatory circuit that drives the mitogenic action of Shh signaling. Shh pathway activation of Foxd1 is followed by downregulation of Cdkn1c, which encodes a cyclin-dependent kinase inhibitor. | Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.
Fink DM, Sun MR, Heyne GW, Everson JL, Chung HM, Park S, Sheets MD, Lipinski RJ., Free PMC Article | 06/29/2019 |
| Here we show that loss of Ezh2 resulted in altered expression of several key cyclin-dependent kinase inhibitors including Cdkn2a (p16 and Arf) and Cdkn1c (p57) in naive CD8+ T cells after activation, which explained the cell cycle impairment of Ezh2-deficient naive CD8+ T cells in response to antigenic stimulation. | Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression.
Chen G, Subedi K, Chakraborty S, Sharov A, Lu J, Kim J, Mi X, Wersto R, Sung MH, Weng NP., Free PMC Article | 05/11/2019 |
| We propose that CDKN1c activity is restricted to differentiating myoblasts by regulated cyto-nuclear relocalization, coordinating the balance between proliferation and growth arrest. | Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells.
Mademtzoglou D, Asakura Y, Borok MJ, Alonso-Martin S, Mourikis P, Kodaka Y, Mohan A, Asakura A, Relaix F., Free PMC Article | 01/12/2019 |
| Cdkn1c expression and methylation may associate with cell cycle exit and differentiation of odontoblasts. | Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.
Li Q, Guo Y, Yao M, Li J, Chen Y, Liu Q, Chen Y, Zeng Y, Ji B, Feng Y., Free PMC Article | 11/24/2018 |
| progenitors are dependent on p57(KIP2)-mediated slowing of replication forks for self-renewal, a novel function for cyclin-dependent kinase inhibitors. The switch to differentiation entails rapid down-regulation of p57(KIP2) with a consequent global increase in replication fork speed and an abruptly shorter S phase. | Global increase in replication fork speed during a p57(KIP2)-regulated erythroid cell fate switch.
Hwang Y, Futran M, Hidalgo D, Pop R, Iyer DR, Scully R, Rhind N, Socolovsky M., Free PMC Article | 10/13/2018 |
| Our data indicate that mouse embryonic stem cells are induced into islet-like cells in vitro. The gene imprinting status of Kcnq1 and Cdkn1c may be changed in differentiated cells during the induction in vitro. | Expression of Imprinted Genes Kcnq1 and Cdkn1c During the Course of Differentiation from Mouse Embryonic Stem Cells into Islet-like Cells in vitro.
Liu F, Yu-Huan P, Qiang L, Chanchan L. | 09/29/2018 |
| the consequence of elevated Cdkn1c expression on dopamine-related behaviours highlighting the importance of correct dosage of this imprinted gene in the brain | Dopaminergic and behavioural changes in a loss-of-imprinting model of Cdkn1c.
McNamara GI, Davis BA, Browne M, Humby T, Dalley JW, Xia J, John RM, Isles AR., Free PMC Article | 09/1/2018 |
| Immunohistochemistry revealed robust p57(kip2) staining in trophoblast giant cells and in the ectoplacental cone at E8.5. p57(kip2) protein was seen in giant cells and throughout the labyrinth, although its abundance was reduced in the junctional zone at E9.5, and became more diffuse by E12.5. | The developmental expression of the CDK inhibitor p57(kip2) (Cdkn1c) in the early mouse placenta.
Saunders AC, McGonnigal B, Uzun A, Padbury J. | 01/20/2018 |
| Cdkn1c-luciferase mice offer non-invasive tools to identify factors that disrupt epigenetic processes. | Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.
Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AG., Free PMC Article | 12/2/2017 |
| this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2). | The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.
Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. | 11/18/2017 |
| This is the first report linking elevated Cdkn1c to altered behaviour in mice. Importantly, the findings from our study may have relevance for Silver Russell Syndrome and highlight a potentially underreported aspect of this disorder. | Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome.
McNamara GI, Davis BA, Dwyer DM, John RM, Isles AR., Free PMC Article | 06/10/2017 |
| Dnmt3a-cKO muscles exhibit fewer Pax7+ SCs, which show increased expression of p57Kip2 protein | Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.
Naito M, Mori M, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H., Free PMC Article | 04/1/2017 |
| indicate that the effects of insulin-like growth factor 2 (IGF2) are mediated by direct upregulation of the cyclin-dependent kinase inhibitor p57 (p57). | Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.
Thomas DD, Sommer AG, Balazs AB, Beerman I, Murphy GJ, Rossi D, Mostoslavsky G., Free PMC Article | 09/10/2016 |
| Data show that transforming growth factor beta (TGFbeta)-induced changes in Gata2 transcription factor and cyclin-dependent kinase inhibitor 1C (P57) expression in hematopoietic progenitors are conveyed through Smad signaling via Smad4 protein. | A network including TGFβ/Smad4, Gata2, and p57 regulates proliferation of mouse hematopoietic progenitor cells.
Billing M, Rörby E, May G, Tipping AJ, Soneji S, Brown J, Salminen M, Karlsson G, Enver T, Karlsson S. | 09/10/2016 |
| This study reveals a key requirement for Cdkn1c in the early development of the brown adipose lineages. | Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM., Free PMC Article | 08/6/2016 |
| Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2 | Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
Cesario JM, Landin Malt A, Deacon LJ, Sandberg M, Vogt D, Tang Z, Zhao Y, Brown S, Rubenstein JL, Jeong J., Free PMC Article | 05/14/2016 |
| hepatoblasts in p57(Kip2)-/- mice were highly proliferative and had deficient maturation compared with those in wild-type (WT) mice. | Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.
Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A. | 03/19/2016 |
| Data indicate that cyclin-dependent kinase inhibitor 1C (P57 was post-transcriptionally regulated by microRNA miR-221 in embryonic stem (ES) cells. | MicroRNA-221 is required for proliferation of mouse embryonic stem cells via P57 targeting.
Li J, Bei Y, Liu Q, Lv D, Xu T, He Y, Chen P, Xiao J. | 12/5/2015 |