| The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis. | The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.
Jahan S, Awaja N, Hess B, Hajjar S, Sad S, Lohnes D., Free PMC Article | 11/19/2022 |
| P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium. | P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium.
Fang Y, Li W, Chen X., Free PMC Article | 12/11/2021 |
| Upregulation of oncogene Activin A receptor type I by Helicobacter pylori infection promotes gastric intestinal metaplasia via regulating CDX2. | Upregulation of oncogene Activin A receptor type I by Helicobacter pylori infection promotes gastric intestinal metaplasia via regulating CDX2.
Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH, Zhu Y. | 11/27/2021 |
| Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. | Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia.
Vu T, Straube J, Porter AH, Bywater M, Song A, Ling V, Cooper L, Pali G, Bruedigam C, Jacquelin S, Green J, Magor G, Perkins A, Chalk AM, Walkley CR, Heidel FH, Mukhopadhyay P, Cloonan N, Gröschel S, Mallm JP, Fröhling S, Scholl C, Lane SW., Free PMC Article | 08/29/2020 |
| Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs. | Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs.
Grall E, Gourain V, Naïr A, Martin E, Birling MC, Freund JN, Duluc I., Free PMC Article | 08/29/2020 |
| By comparing our gastrointestinal lineage-specific transcriptome to human gastrointestinal cancer data, we found that stomach and intestinal lineage-specific programs are reactivated in Sox2(high) /Sox9(high) and Cdx2(high) cancers, respectively | Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer.
Francis R, Guo H, Streutker C, Ahmed M, Yung T, Dirks PB, He HH, Kim TH., Free PMC Article | 06/6/2020 |
| Cdx2-eGFP cells may potentially represent a therapeutic advance in allogeneic cell therapy for cardiac repair. | Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.
Vadakke-Madathil S, LaRocca G, Raedschelders K, Yoon J, Parker SJ, Tripodi J, Najfeld V, Van Eyk JE, Chaudhry HW., Free PMC Article | 03/21/2020 |
| CDX2 regulates chromatin to control distinct stages of intestine development | The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development.
Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP., Free PMC Article | 01/4/2020 |
| In mice, mosaic knockout of Cdx2 in the adult intestinal epithelium induces the formation of imperfect gastric-type metaplastic lesions. | The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.
Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, Onea A, Deschamps J, Beck F, Freund JN, Duluc I., Free PMC Article | 04/6/2019 |
| Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells. | Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells.
Rayon T, Menchero S, Rollán I, Ors I, Helness A, Crespo M, Nieto A, Azuara V, Rossant J, Manzanares M., Free PMC Article | 04/28/2018 |
| AMPK enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter. | AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression.
Sun X, Yang Q, Rogers CJ, Du M, Zhu MJ., Free PMC Article | 02/17/2018 |
| CDX2(Null)/BRAF(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF(V600E)-mutant epithelium expressed gastric markers. | BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.
Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER., Free PMC Article | 02/10/2018 |
| including Wnt and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx/Hox and T Brachyury transcriptional networks controls differential axial growth during vertebrate trunk elongation | Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J. | 11/25/2017 |
| A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha in human biopsy samples. | Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.
Colleypriest BJ, Burke ZD, Griffiths LP, Chen Y, Yu WY, Jover R, Bock M, Biddlestone L, Quinlan JM, Ward SG, Mark Farrant J, Slack JMW, Tosh D., Free PMC Article | 08/19/2017 |
| Cdx members interact with the SWI-SNF complex and make direct contact with Brg1, a catalytic member of SWI-SNF. Both Cdx2 and Brg1 co-occupy a number of Cdx target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci. | Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.
Nguyen TT, Savory JGA, Brooke-Bisschop T, Ringuette R, Foley T, Hess BL, Mulatz KJ, Trinkle-Mulcahy L, Lohnes D., Free PMC Article | 06/24/2017 |
| The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox gene. | Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.
Neijts R, Amin S, van Rooijen C, Deschamps J. | 06/3/2017 |
| Cdx1-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac and a block in hematopoietic differentiation from yolk sac-derived cells in culture. | Essential roles for Cdx in murine primitive hematopoiesis.
Brooke-Bisschop T, Savory JGA, Foley T, Ringuette R, Lohnes D. | 06/3/2017 |
| this study shows that Aloe vera gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer | Prevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by processed Aloe vera gel.
Im SA, Kim JW, Kim HS, Park CS, Shin E, Do SG, Park YI, Lee CK. | 04/22/2017 |
| Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 and Cdx2 in colon cancer cells. | Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.
Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C. | 09/3/2016 |
| CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs may be activated or repressed. | Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.
San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA., Free PMC Article | 08/27/2016 |
| cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass. | Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes.
Toyooka Y, Oka S, Fujimori T. | 08/6/2016 |
| findings illuminated a role for NOD1 signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells | Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses.
Asano N, Imatani A, Watanabe T, Fushiya J, Kondo Y, Jin X, Ara N, Uno K, Iijima K, Koike T, Strober W, Shimosegawa T., Free PMC Article | 07/30/2016 |
| Overexpression of CDX2 inhibits the growth of the gastric cancer cells in vivo and in vitro. | Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo.
Wei W, Li L, Wang X, Yan L, Cao W, Zhan Z, Zhang X, Yu H, Xie Y, Xiao Q., Free PMC Article | 01/2/2016 |
| Intestinal stem cells transform into gastric stem cells on loss of transcription factor Cdx2. | Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.
Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J., Free PMC Article | 11/7/2015 |
| GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2 | Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.
San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP., Free PMC Article | 05/9/2015 |