| The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation. | The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation.
Duan J, Grando C, Liu S, Chernyavsky A, Chen JK, Andersen B, Grando SA., Free PMC Article | 11/26/2022 |
| Pancreas-specific CHRM3 activation causes pancreatitis in mice. | Pancreas-specific CHRM3 activation causes pancreatitis in mice.
Wan J, Wang J, Wagner LE 2nd, Wang OH, Gui F, Chen J, Zhu X, Haddock AN, Edenfield BH, Haight B, Mukhopadhyay D, Wang Y, Yule DI, Bi Y, Ji B., Free PMC Article | 03/26/2022 |
| Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling. | Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling.
Takahashi T, Shiraishi A, Murata J, Matsubara S, Nakaoka S, Kirimoto S, Osawa M., Free PMC Article | 01/15/2022 |
| Inhibition of CHRM3 Alleviates Necrosis Via the MAPK-p38/miR-31-5p/RIP3 Axis in L-Arginine-Induced Severe Acute Pancreatitis. | Inhibition of CHRM3 Alleviates Necrosis Via the MAPK-p38/miR-31-5p/RIP3 Axis in L-Arginine-Induced Severe Acute Pancreatitis.
Luan J, Kou J, Huang N, Tao Y, Shi S, Wu X, Sun Y, Meng D, Xu J, Zhou X, Murtaza G, Bobkov A, Qiao Y, Gao X, Ma N. | 10/2/2021 |
| Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice. | Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice.
Tanahashi Y, Komori S, Matsuyama H, Kitazawa T, Unno T., Free PMC Article | 09/11/2021 |
| Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease. | Aged Mice Devoid of the M(3) Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease.
Musayeva A, Jiang S, Ruan Y, Zadeh JK, Chronopoulos P, Pfeiffer N, Müller WEG, Ackermann M, Xia N, Li H, Gericke A., Free PMC Article | 07/31/2021 |
| Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury. | Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa A, Haage V, Yang S, Wegner S, Ersoy B, Ugursu B, Rex A, Kronenberg G, Gertz K, Endres M, Wolf SA, Kettenmann H. | 06/5/2021 |
| A Chrm3 missense T1667C mutation in the last intracellular domain functionally correlated with a rise in BP increased the M3R signalling and resensitization, and adrenal epinephrogenesis. Gene targeting that abolished the M3R function without affecting any of noncoding Chrm3 variants caused a decrease in BP, indicating that the M3R-mediated signalling promotes hypertension. | Functional Dosage of Muscarinic Cholinergic Receptor 3 Signalling, Not the Gene Dose, Determines Its Hypertension Pathogenesis.
Deng AY, Huot-Marchard JÉ, deBlois D, Thorin E, Chauvet C, Menard A. | 02/22/2020 |
| Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level. These results suggest that muscarinic acetylcholine receptors, Chrm1 and Chrm3, are essential for REM sleep. | Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Niwa Y, Kanda GN, Yamada RG, Shi S, Sunagawa GA, Ukai-Tadenuma M, Fujishima H, Matsumoto N, Masumoto KH, Nagano M, Kasukawa T, Galloway J, Perrin D, Shigeyoshi Y, Ukai H, Kiyonari H, Sumiyama K, Ueda HR. | 02/1/2020 |
| Genetic M3R ablation in mouse cells results in improved remyelination and is mediated by acceleration of oligodendrocyte commitment from oligodendrocyte progenitor cells. | Muscarinic Receptor M(3)R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells.
Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O'Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ., Free PMC Article | 10/26/2019 |
| The expression of M3-mAChR was down-regulated in the myocardium from aged mice and D-galactose-treated mice, while the expression levels of caspase-1 and its downstream molecule IL-1beta were significantly increased. | Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway.
Wang S, Jiang Y, Chen J, Dai C, Liu D, Pan W, Wang L, Fasae MB, Sun L, Wang L, Liu Y. | 10/13/2018 |
| Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function | Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.
Wang Q, Pronin AN, Levay K, Almaca J, Fornoni A, Caicedo A, Slepak VZ., Free PMC Article | 11/25/2017 |
| s. Moreover, we found that M3 cholinergic receptor (CHRM3) was upregulated in a large subset of benign prostatic hyperplasia (BPH) tissues compared with normal tissues. Activation of CHRM3 also promoted the proliferation of BPH cells. | Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status.
Wang N, Dong BJ, Quan Y, Chen Q, Chu M, Xu J, Xue W, Huang YR, Yang R, Gao WQ., Free PMC Article | 11/25/2017 |
| early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reversed the progression of airway hyperreactivity in the neonatal exposure model, whereas beta2-adrenoceptor agonists had no such effect | Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma.
Patel KR, Bai Y, Trieu KG, Barrios J, Ai X., Free PMC Article | 10/21/2017 |
| We found that knockout of the M2/3 receptor significantly inhibited ST37 acupuncture-induced enhancement of gastric motility, jejunal motility, and colonic motility. | β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints.
Gao X, Zhao Y, Su Y, Liu K, Yu X, Cui C, Yang Z, Shi H, Jing X, Zhu B., Free PMC Article | 07/8/2017 |
| Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines. | Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines.
McLean LP, Smith A, Cheung L, Urban JF Jr, Sun R, Grinchuk V, Desai N, Zhao A, Raufman JP, Shea-Donohue T., Free PMC Article | 06/24/2017 |
| Arthritis-induced joint destruction was significantly stronger in mice with M3 muscarinic acetylcholine receptor deficiency. | Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis.
Beckmann J, Dittmann N, Schütz I, Klein J, Lips KS., Free PMC Article | 10/8/2016 |
| The effects of muscarinic receptor M3 knockout on cathepsin K expression, bone density and biomechanical properties of bone are reported. | Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice.
Lips KS, Kneffel M, Willscheid F, Mathies FM, Kampschulte M, Hartmann S, Panzer I, Dürselen L, Heiss C, Kauschke V. | 09/17/2016 |
| results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS diagnosis | Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome.
Chen Y, Zheng J, Huang Q, Deng F, Huang R, Zhao W, Yin J, Song L, Chen J, Gao X, Liu Z, Petersen F, Yu X., Free PMC Article | 07/16/2016 |
| Expression of the M3 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras-/- males and females, although only males exhibited a urinary phenotype. | Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Ehrhardt A, Wang B, Yung AC, Wang Y, Kozlowski P, van Breemen C, Schrader JW., Free PMC Article | 06/28/2016 |
| The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro. | Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Hallock PT, Chin S, Blais S, Neubert TA, Glass DJ., Free PMC Article | 05/21/2016 |
| Activation of Chrm3 inhibits the recruitment of beta-arrestin-2 to odorant receptors, resulting in a potentiation of odor-induced responses in olfactory sensory neurons. | Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.
Jiang Y, Li YR, Tian H, Ma M, Matsunami H., Free PMC Article | 03/26/2016 |
| The muscarinic M3R receptor interacts directly with NOSTRIN at the plasma membrane in the aorta. | The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.
Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, Hindemith T, Schermuly RT, Fleming I, Hoffmeister M, Oess S. | 10/31/2015 |
| Cholinergic signalling via the M3R is essential for optimal Th1 and Th2 adaptive immunity to infection. | The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.
Darby M, Schnoeller C, Vira A, Culley FJ, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WG., Free PMC Article | 10/10/2015 |
| These findings indicate that the M(3) receptor on structural cells plays a proinflammatory role in CS-induced neutrophilic inflammation, whereas the M(3) receptor on inflammatory cells does not. | Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.
Kistemaker LE, van Os RP, Dethmers-Ausema A, Bos IS, Hylkema MN, van den Berge M, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R., Free PMC Article | 03/21/2015 |