| Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles. | Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles.
Fei X, Li Z, Yang D, Kong X, Lu X, Shen Y, Li X, Xie S, Wang J, Zhao Y, Sun Y, Zhang J, Ye Z, Wang J, Cai Z., Free PMC Article | 02/26/2022 |
| Coronin 1 Is Required for Integrin beta2 Translocation in Platelets. | Coronin 1 Is Required for Integrin β2 Translocation in Platelets.
Riley DRJ, Khalil JS, Pieters J, Naseem KM, Rivero F., Free PMC Article | 10/24/2020 |
| this study shows that disruption of Coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity | Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity.
Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang MJ, Fucile G, Mazumder S, Tchang V, Woischnig AK, Stiess M, Kunz G, Claudi B, Schmaler M, Siegmund K, Li J, Dertschnig S, Holländer G, Medina E, Karrer U, Moshous D, Bumann D, Khanna N, Rossi SW, Pieters J. | 07/6/2019 |
| PtpA from Staphylococcus aureus contributes to virulence and interacts with coronin-1A during infection. | PtpA, a secreted tyrosine phosphatase from Staphylococcus aureus, contributes to virulence and interacts with coronin-1A during infection.
Gannoun-Zaki L, Pätzold L, Huc-Brandt S, Baronian G, Elhawy MI, Gaupp R, Martin M, Blanc-Potard AB, Letourneur F, Bischoff M, Molle V., Free PMC Article | 03/9/2019 |
| Coro1A has a role in platelet biology with impact on spreading, aggregation and thrombosis | The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
Stocker TJ, Pircher J, Skenderi A, Ehrlich A, Eberle C, Megens RTA, Petzold T, Zhang Z, Walzog B, Müller-Taubenberger A, Weber C, Massberg S, Ishikawa-Ankerhold H, Schulz C. | 02/2/2019 |
| our findings indicate that coronin 1A is a pivotal component that regulates lysosomal fusion and the secretion pathway in osteoclast-lineage cells and may provide a novel therapeutic target for bone diseases. | Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.
Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M., Free PMC Article | 10/27/2018 |
| these data suggest that coronin 1 is dispensable for mouse NK cell homeostasis and function. | Role for coronin 1 in mouse NK cell function.
Tchang VSY, Stiess M, Siegmund K, Karrer U, Pieters J. | 12/9/2017 |
| Results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis. | A Coronin 1-Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment.
Lang MJ, Mori M, Ruer-Laventie J, Pieters J. | 10/28/2017 |
| Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity. | Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity.
Pick R, Begandt D, Stocker TJ, Salvermoser M, Thome S, Böttcher RT, Montanez E, Harrison U, Forné I, Khandoga AG, Coletti R, Weckbach LT, Brechtefeld D, Haas R, Imhof A, Massberg S, Sperandio M, Walzog B. | 09/30/2017 |
| the phenotype of T cell-specific Coronin 1a deletion resembles the phenotype observed with conventional (whole body) Coronin 1a knock-out mice. In summary, our findings provide formal proof of the predominant T cell-intrinsic role of Coronin 1A. | Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G., Free PMC Article | 05/27/2017 |
| phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Galphas association and the modulation of cAMP production | Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity.
Liu X, BoseDasgupta S, Jayachandran R, Studer V, Rühl S, Stiess M, Pieters J. | 06/11/2016 |
| Authors report that this mutation induces pleiotropic effects in Coro1A protein, including the exacerbation of Coro1A-dependent actin-binding and -bundling activities. | The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.
Ojeda V, Robles-Valero J, Barreira M, Bustelo XR., Free PMC Article | 05/28/2016 |
| Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. | Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
Siegmund K, Thuille N, Posch N, Fresser F, Baier G., Free PMC Article | 09/26/2015 |
| An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1. | Cytokine-induced macropinocytosis in macrophages is regulated by 14-3-3ζ through its interaction with serine-phosphorylated coronin 1.
BoseDasgupta S, Moes S, Jenoe P, Pieters J. | 06/20/2015 |
| this work suggests that periods before and after NGF-TrkA-induced Coronin-1 expression (and likely other factors) defines two distinct axon growth states | Coronin-1 and calcium signaling governs sympathetic final target innervation.
Suo D, Park J, Young S, Makita T, Deppmann CD., Free PMC Article | 05/2/2015 |
| Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. | The expanding spectrum of human coronin 1A deficiency.
Moshous D, de Villartay JP. | 12/20/2014 |
| Our results indicate that Abp1 negatively regulates BCR signaling by coupling actin remodeling to B-cell contraction and activation of inhibitory signaling molecules | Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.
Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan TH, Upadhyaya A, Song W., Free PMC Article | 09/20/2014 |
| Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease. | Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease.
Fulton LM, Taylor NA, Coghill JM, West ML, Föger N, Bear JE, Baldwin AS, Panoskaltsis-Mortari A, Serody JS., Free PMC Article | 07/26/2014 |
| These results suggest that coronin 1, while important for naive T cell survival, is dispensable for other leukocyte function under inflammatory conditions in vivo. | Coronin 1 is dispensable for leukocyte recruitment and liver injury in concanavalin A-induced hepatitis.
Siegmund K, Lee WY, Tchang VS, Stiess M, Terracciano L, Kubes P, Pieters J. | 04/5/2014 |
| The results of this study establish Coronin-1 as an essential component of a feedback loop that mediates NGF-TrkA endosome stability, recycling and signaling as a critical mechanism governing developmental competition for survival. | Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.
Suo D, Park J, Harrington AW, Zweifel LS, Mihalas S, Deppmann CD., Free PMC Article | 03/1/2014 |
| Data suggest that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation. | Diverging role for coronin 1 in antiviral CD4+ and CD8+ T cell responses.
Tchang VS, Mekker A, Siegmund K, Karrer U, Pieters J. | 12/21/2013 |
| Coronin 1 is dispensable for antigen processing and presentation by dendritic cells. | Antigen processing and presentation by dendritic cells is independent of coronin 1.
Westritschnig K, BoseDasgupta S, Tchang V, Siegmund K, Pieters J. | 03/2/2013 |
| These results suggest that Coro1a inhibits autophagosome formation in alveolar macrophages, thereby facilitating Mycobacterium tuberculosis survival within the lung. | Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages.
Seto S, Tsujimura K, Koide Y. | 08/11/2012 |
| Coro1A controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages. | Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages.
Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E. | 04/21/2012 |
| GRAIL functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2/3-5 and coronin 1A | GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.
Ichikawa D, Mizuno M, Yamamura T, Miyake S., Free PMC Article | 03/31/2012 |