| Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression. | Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression.
Zhu L, Tang N, Hang H, Zhou Y, Dong J, Yang Y, Mao L, Qiu Y, Fu X, Cao W. | 03/19/2024 |
| Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1. | Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1.
Hou A, Mohamed Ali S, Png E, Hunziker W, Tong L. | 08/14/2023 |
| Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice. | Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice.
Suzuki K, Yamaga K, Tokumasu R, Katsuno T, Tanaka H, Chiba S, Yagi T, Katayama I, Tamura A, Murota H, Tsukita S. | 05/19/2023 |
| Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. | Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis.
Fatima I, Uppada JP, Chhonker YS, Gowrikumar S, Barman S, Roy S, Tolentino KT, Palermo N, Natarajan A, Beauchamp DR, Vecchio A, Murry DJ, Singh AB, Hopkins CR, Dhawan P., Free PMC Article | 02/10/2023 |
| A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity. | A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity.
Roehlen N, Saviano A, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, Jühling F, Oudot MA, Durand SC, Duong FHT, Cherradi S, Gonzalez Motos V, Almeida N, Ponsolles C, Heydmann L, Ostyn T, Lallement A, Pessaux P, Felli E, Cavalli A, Sgrignani J, Thumann C, Koutsopoulos O, Fuchs BC, Hoshida Y, Hofmann M, Vyberg M, Viuff BM, Galsgaard ED, Elson G, Toso A, Meyer M, Iacone R, Schweighoffer T, Teixeira G, Moll S, De Vito C, Roskams T, Davidson I, Heide D, Heikenwälder M, Zeisel MB, Lupberger J, Mailly L, Schuster C, Baumert TF. | 01/14/2023 |
| Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March. | Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March.
Xia Y, Cao H, Zheng J, Chen L., Free PMC Article | 07/23/2022 |
| Inhibition of glycogen synthase kinase 3beta improves cognitive function in aged mice by upregulating claudin presences in cerebral endothelial cells. | Inhibition of glycogen synthase kinase 3β improves cognitive function in aged mice by upregulating claudin presences in cerebral endothelial cells.
Liang T, Ju H, Zhou Y, Yang Y, Shi Y, Fang H. | 01/9/2021 |
| Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1-Deficient Mice. | Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1-Deficient Mice.
Atsugi T, Yokouchi M, Hirano T, Hirabayashi A, Nagai T, Ohyama M, Abe T, Kaneko M, Zouboulis CC, Amagai M, Kubo A. | 09/19/2020 |
| eosinophilic esophagitis (EoE) patient biopsy analysis identified a repressed HIF-1alpha/claudin-1 axis, which was restored via pharmacologic HIF-1alpha stabilization ex vivo. Collectively, these studies reveal HIF-1alpha's critical role in maintaining barrier and highlight the HIF-1alpha/claudin-1 axis as a potential therapeutic target for EoE. | Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis.
Masterson JC, Biette KA, Hammer JA, Nguyen N, Capocelli KE, Saeedi BJ, Harris RF, Fernando SD, Hosford LB, Kelly CJ, Campbell EL, Ehrentraut SF, Ahmed FN, Nakagawa H, Lee JJ, McNamee EN, Glover LE, Colgan SP, Furuta GT., Free PMC Article | 05/30/2020 |
| claudin-1 is incorporated in blood-brain barrier tight junction complex, impeding blood-brain barrier recovery and causing blood-brain barrier leakiness during poststroke recovery | Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke.
Sladojevic N, Stamatovic SM, Johnson AM, Choi J, Hu A, Dithmer S, Blasig IE, Keep RF, Andjelkovic AV., Free PMC Article | 12/21/2019 |
| In SAMP10 mice, in addition to preventing a decrease in the naive T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased. | Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence.
Tsuji R, Komano Y, Ohshio K, Ishii N, Kanauchi O. | 07/13/2019 |
| Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a | Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa.
Gruber S, Cini N, Kowald LM, Mayer J, Rohorzka A, Kuess P, Dörr W., Free PMC Article | 09/22/2018 |
| Taken together, these results demonstrate that BTZ-induced claudin 1 expression may be a valuable therapeutic approach for AD. | Bortezomib, a proteasome inhibitor, alleviates atopic dermatitis by increasing claudin 1 protein expression.
Kim YE, Cho N, Cheon S, Kim KK. | 10/21/2017 |
| Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea. | TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea.
Wardill HR, Bowen JM, Van Sebille YZ, Secombe KR, Coller JK, Ball IA, Logan RM, Gibson RJ. | 06/24/2017 |
| The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1. | miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1.
Mahati S, Xiao L, Yang Y, Mao R, Bao Y. | 06/3/2017 |
| Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri. | Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation.
Sun X, Park CB, Deng W, Potter SS, Dey SK., Free PMC Article | 08/27/2016 |
| Cldn-1 is a positive regulator of osteoblast proliferation and differentiation. | Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.
Alshbool FZ, Mohan S., Free PMC Article | 12/12/2015 |
| We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions. | Keratin 76 is required for tight junction function and maintenance of the skin barrier.
DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM., Free PMC Article | 07/4/2015 |
| MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. | MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.
Zhou Q, Costinean S, Croce CM, Brasier AR, Merwat S, Larson SA, Basra S, Verne GN., Free PMC Article | 03/7/2015 |
| Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis. | Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.
Kyoko OO, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, Shibata S, Nakao A., Free PMC Article | 01/17/2015 |
| regulates intestinal epithelial homeostasis via regulation of Notch-signalling | Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P., Free PMC Article | 04/26/2014 |
| Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria. | Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H., Free PMC Article | 01/25/2014 |
| Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects. | Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice.
Sugawara T, Iwamoto N, Akashi M, Kojima T, Hisatsune J, Sugai M, Furuse M. | 10/19/2013 |
| miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1 | MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1.
Qin W, Ren Q, Liu T, Huang Y, Wang J. | 06/15/2013 |
| we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages | Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.
Van den Bossche J, Laoui D, Morias Y, Movahedi K, Raes G, De Baetselier P, Van Ginderachter JA. | 07/21/2012 |