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    Clu clusterin [ Mus musculus (house mouse) ]

    Gene ID: 12759, updated on 6-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.

    Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.
    Tian Y, Xiao YH, Geng T, Sun C, Gu J, Tang KF, Liu B, Liu YM, Sun F.

    Regulation of adipocyte differentiation by clusterin-mediated Kruppel-like factor 5 stabilization.

    Regulation of adipocyte differentiation by clusterin-mediated Krüppel-like factor 5 stabilization.
    Oh GS, Yoon J, Kim G, Kim GH, Kim DS, Choi B, Chang EJ, Lee ES, Kim SW.

    Clusterin overexpression protects against western diet-induced obesity and NAFLD.

    Clusterin overexpression protects against western diet-induced obesity and NAFLD.
    Park JS, Lee WK, Kim HS, Seo JA, Kim DH, Han HC, Min BH., Free PMC Article

    Study identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a LRP2-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake.

    Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
    Seo JA, Kang MC, Yang WM, Hwang WM, Kim SS, Hong SH, Heo JI, Vijyakumar A, Pereira de Moura L, Uner A, Huang H, Lee SH, Lima IS, Park KS, Kim MS, Dagon Y, Willnow TE, Aroda V, Ciaraldi TP, Henry RR, Kim YB., Free PMC Article

    Clusterin was upregulated in the livers of thioacetamide (TAA)-induced and bile duct ligation mouse models of liver fibrosis. Its loss and overexpression promoted and attenuated hepatic fibrosis after TAA injection, respectively. Thus, clusterin plays an important role in hepatic fibrosis.

    Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway.
    Seo HY, Lee SH, Lee JH, Kang YN, Choi YK, Hwang JS, Park KG, Jang BK, Kim MK., Free PMC Article

    Clusterin deficiency induces renal lipid accumulation by dysregulating the expression of lipid metabolism-related factors and TGFB1, thereby leading to chronic kidney disease. Hence, clusterin may serve as a therapeutic target for lipid-induced chronic kidney disease.

    Clusterin deficiency induces lipid accumulation and tissue damage in kidney.
    Heo JY, Kim JE, Dan Y, Kim YW, Kim JY, Cho KH, Bae YK, Im SS, Liu KH, Song IH, Kim JR, Lee IK, Park SY.

    The fibrotic response in Clusterin deficient (CLU-/-) mice persisted after bleomycin and it was associated with increased DNA damage, reduced DNA repair responses, and elevated cellular senescence. Remarkably, this pattern mirrored that observed in idiopathic pulmonary fibrosis patients lung tissues.

    Divergent roles for Clusterin in Lung Injury and Repair.
    Habiel DM, Camelo A, Espindola M, Burwell T, Hanna R, Miranda E, Carruthers A, Bell M, Coelho AL, Liu H, Pilataxi F, Clarke L, Grant E, Lewis A, Moore B, Knight DA, Hogaboam CM, Murray LA., Free PMC Article

    the role of CLU in the emergence, recovery, and repair of gastric metaplasia after tamoxifen-induced acute oxyntic atrophy, is reported.

    Subtle Protective Roles of Clusterin in Gastric Metaplasia After Acute Oxyntic Atrophy.
    Vange P, Bruland T, Munkvold B, Røyset ES, Gleave M, Bakke I., Free PMC Article

    Data identified sCLU as a regulator of mBMSCs lineage commitment to osteoblasts versus adipocytes through a mechanism mediated by ERK1/2 signaling. Inhibiting sCLU is a possible therapeutic approach for enhancing osteoblast differentiation and consequently bone formation.

    Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway.
    Abdallah BM, Alzahrani AM, Kassem M.

    Results of quantitative real-time polymerase chain reaction analysis showed that Clu mRNA levels in the inner ear were increased during embryogenesis and were constantly expressed in the adult.

    Spatiotemporal expression patterns of clusterin in the mouse inner ear.
    Lee S, Shin JO, Sagong B, Kim UK, Bok J.

    Exposure of primary hippocampal neurons to Abeta42 induced an overexpression of intracellular clusterin, but the level of clusterin in supernatants did not change. Moreover, in APP/PSEN1 mice, there was a significant increase in intracellular clusterin in cortex and hippocampus, compared to age-matched wild-type (WT) mice, while serum clusterin level in APP/PSEN1 mice and in WT mice has no significant difference.

    β-Amyloid Upregulates Intracellular Clusterin but not Secretory Clusterin in Primary Cultured Neurons and APP Mice.
    Wang P, Chen K, Gu Y, Guo Q, Hong Z, Zhao Q.

    These findings suggest that in the absence of CLU, Abeta clearance shifts to perivascular drainage pathways, resulting in fewer parenchymal plaques but more CAA because of loss of CLU chaperone activity, complicating the potential therapeutic targeting of CLU for AD.

    Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.
    Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD., Free PMC Article

    Sustained expression of clusterin in liver functioned as a preconditioning stimulus and prevented methionine and choline deficient (MCD) diet-induced severe steatohepatitis injury via Nrf2 activation.

    Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
    Park JS, Shim YJ, Kang BH, Lee WK, Min BH.

    Clusterin deficiency worsens renal inflammation and tissue fibrosis after ischemia-reperfusion injury in the kidney.

    Relationship of clusterin with renal inflammation and fibrosis after the recovery phase of ischemia-reperfusion injury.
    Guo J, Guan Q, Liu X, Wang H, Gleave ME, Nguan CY, Du C., Free PMC Article

    The results identify Clusterin as a new molecular partner involved in apoptotic cell efferocytosis and suggest a protective role for Clusterin in inflammation and autoimmune diseases.

    Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.
    Cunin P, Beauvillain C, Miot C, Augusto JF, Preisser L, Blanchard S, Pignon P, Scotet M, Garo E, Fremaux I, Chevailler A, Subra JF, Blanco P, Wilson MR, Jeannin P, Delneste Y., Free PMC Article

    Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD.

    Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.
    Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD., Free PMC Article

    clusterin-induced TNF-alpha and MMP-9 up-regulation is most likely mediated via TLR4 recruitment into lipid rafts; clusterin has a role as an endogenous regulator for TLR4 signaling

    Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-α secretion in macrophage.
    Shim YJ, Tae YK, Kang BH, Park JS, Jeon SY, Min BH.

    susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 alterations

    Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.
    Iyer S, Park MJ, Moons D, Kwan R, Liao J, Liu L, Omary MB., Free PMC Article

    the antioxidant property of clusterin is suggested to regulate the expression of CCL20 in bronchial epithelial cells and the subsequent recruitment of inflammatory dendritic cells in the airway.

    Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
    Hong GH, Kwon HS, Moon KA, Park SY, Park S, Lee KY, Ha EH, Kim TB, Moon HB, Lee HK, Cho YS.

    these data suggest that activation of prosurvival autophagy by hypoxia in kidney cells requires CLU expression and may be a key cytoprotective mechanism of CLU in the protection of the kidney from hypoxia/ischemia-mediated injury.

    Requirement of clusterin expression for prosurvival autophagy in hypoxic kidney tubular epithelial cells.
    Alnasser HA, Guan Q, Zhang F, Gleave ME, Nguan CY, Du C.

    Taken together, our results suggest that an NCE-box within the clusterin promoter is necessary for insulin-stimulated hepatic expression of clusterin via SREBP-1c.

    The E-box-like sterol regulatory element mediates the insulin-stimulated expression of hepatic clusterin.
    Oh GS, Kim G, Yoon J, Kim GH, Kim SW.

    Overexpression of clusterin in proximal tubular epithelial cells decreased the levels of Ang II-stimulated fibrotic markers and AT1R.

    Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
    Jung GS, Jeon JH, Jung YA, Choi YK, Kim HS, Kim JG, Park KG, Kim MK, Lee IK., Free PMC Article

    Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.

    Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.
    Zhang F, Kumano M, Beraldi E, Fazli L, Du C, Moore S, Sorensen P, Zoubeidi A, Gleave ME., Free PMC Article

    Results suggest that regulation of clusterin expression by the lymphotoxin beta signaling pathway and its protein dynamics during immune response suggest a specific role of in the immune system.

    Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
    Afanasyeva MA, Britanova LV, Korneev KV, Mitkin NA, Kuchmiy AA, Kuprash DV., Free PMC Article

    we have identified hypothalamic clusterin as a novel anorexigenic molecule that can potentiate central leptin activity.

    Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.
    Byun K, Gil SY, Namkoong C, Youn BS, Huang H, Shin MS, Kang GM, Kim HK, Lee B, Kim YB, Kim MS., Free PMC Article

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