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    Col5a1 collagen, type V, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12831, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A potential mechanism by which aspiration of duodenogastric fluid augments the risk for bronchiolitis obliterans syndrome after lung transplantation.

    A potential mechanism by which aspiration of duodenogastric fluid augments the risk for bronchiolitis obliterans syndrome after lung transplantation.
    Olson MT, Liu W, Mohanakumar T, Bremner RM.

    01/21/2023
    Molecular alterations due to Col5a1 haploinsufficiency in a mouse model of classic Ehlers-Danlos syndrome.

    Molecular alterations due to Col5a1 haploinsufficiency in a mouse model of classic Ehlers-Danlos syndrome.
    Machol K, Polak U, Weisz-Hubshman M, Song IW, Chen S, Jiang MM, Chen-Evenson Y, Weis MAE, Keene DR, Eyre DR, Lee BH., Free PMC Article

    04/30/2022
    Haploinsufficiency of Col5a1 causes intrinsic lung and respiratory changes in a mouse model of classical Ehlers-Danlos syndrome.

    Haploinsufficiency of Col5a1 causes intrinsic lung and respiratory changes in a mouse model of classical Ehlers-Danlos syndrome.
    Fett J, Dimori M, Carroll JL, Morello R., Free PMC Article

    04/30/2022
    Collagen V insufficiency in a mouse model for Ehlers Danlos-syndrome affects viscoelastic biomechanical properties explaining thin and brittle corneas.

    Collagen V insufficiency in a mouse model for Ehlers Danlos-syndrome affects viscoelastic biomechanical properties explaining thin and brittle corneas.
    Kling S, Torres-Netto EA, Abdshahzadeh H, Espana EM, Hafezi F., Free PMC Article

    12/11/2021
    COL5A1 may contribute the metastasis of lung adenocarcinoma.

    COL5A1 may contribute the metastasis of lung adenocarcinoma.
    Liu W, Wei H, Gao Z, Chen G, Liu Y, Gao X, Bai G, He S, Liu T, Xu W, Yang X, Jiao J, Xiao J.

    06/9/2018
    Significantly decreased fibroblast proliferation was observed in Col5a1(+/-) compared to Col5a1(+/+) fibroblasts.

    Altered dermal fibroblast behavior in a collagen V haploinsufficient murine model of classic Ehlers-Danlos syndrome.
    DeNigris J, Yao Q, Birk EK, Birk DE., Free PMC Article

    11/12/2016
    Col5a1 knockout stroma demonstrated severe dysfunctional regulation of fibrillogenesis.

    Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model.
    Sun M, Chen S, Adams SM, Florer JB, Liu H, Kao WW, Wenstrup RJ, Birk DE., Free PMC Article

    04/21/2012
    Sp7/Osterix was observed to participate in the activation of the Col5a1 promoter during osteoblast differentiation.

    Sp7/Osterix is involved in the up-regulation of the mouse pro-α1(V) collagen gene (Col5a1) in osteoblastic cells.
    Wu YF, Matsuo N, Sumiyoshi H, Yoshioka H.

    07/23/2011
    Col(V) is an established autoantigen in atherosclerotic mice, and Col(V) autoimmunity is a consistent feature, with variable T helper type (Th)1 cell pathway involvement.

    Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis.
    Dart ML, Jankowska-Gan E, Huang G, Roenneburg DA, Keller MR, Torrealba JR, Rhoads A, Kim B, Bobadilla JL, Haynes LD, Wilkes DS, Burlingham WJ, Greenspan DS., Free PMC Article

    11/27/2010
    collagen type V has a critical role in early fibril initiation

    Type V collagen controls the initiation of collagen fibril assembly.
    Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE.

    01/21/2010
    col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages

    Murine model of the Ehlers-Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages.
    Wenstrup RJ, Florer JB, Davidson JM, Phillips CL, Pfeiffer BJ, Menezes DW, Chervoneva I, Birk DE.

    01/21/2010
    ColVa1+/- and ColXIa1-/- mutants were used to identify roles for ColVa1 and ColXIa1 in ventricular myocardial morphogenesis and heart valve development.

    ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development.
    Lincoln J, Florer JB, Deutsch GH, Wenstrup RJ, Yutzey KE.

    01/21/2010
    analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer

    Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer.
    Gopalakrishnan B, Wang WM, Greenspan DS.

    01/21/2010
    COL5A1 is regulated by TGF-beta in osteoblasts

    Collagen, type V, alpha1 (COL5A1) is regulated by TGF-beta in osteoblasts.
    Kahai S, Vary CP, Gao Y, Seth A.

    01/21/2010
    This study shows the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse.

    Distribution of collagen types I, III, and V in pregnant mouse endometrium.
    Spiess K, Teodoro WR, Zorn TM.

    01/21/2010
    CBF activated the Col5a1 promoter suggesting that CBF is a key factor in the coordinated expression of type I and V collagen genes

    Identification of a functional CBF-binding CCAAT-like motif in the core promoter of the mouse pro-alpha 1(V) collagen gene (Col5a1).
    Sakata-Takatani K, Matsuo N, Sumiyoshi H, Tsuda T, Yoshioka H.

    01/21/2010
    Type V collagen contributes to the development of functional connective tissues during embryogenesis.

    A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues.
    Roulet M, Ruggiero F, Karsenty G, LeGuellec D.

    01/21/2010
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