| Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity. | Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity.
Castillo-González J, Ruiz JL, Serrano-Martínez I, Forte-Lago I, Ubago-Rodriguez A, Caro M, Pérez-Gómez JM, Benítez-Troncoso A, Andrés-León E, Sánchez-Navarro M, Luque RM, González-Rey E., Free PMC Article | 11/1/2023 |
| Cortistatin protects against inflammatory airway diseases through curbing CCL2 and antagonizing NF-kappaB signaling pathway. | Cortistatin protects against inflammatory airway diseases through curbing CCL2 and antagonizing NF-κB signaling pathway.
Qiu C, Li J, Luo D, Chen X, Qu R, Liu T, Li F, Liu Y. | 03/20/2021 |
| BDNF, signaling through TrkB receptors on cortistatin-expressing cells, promotes excitatory drive onto these cells. Loss of excitatory drive onto CST-expressing cells that lack TrkB receptors may contribute to observed hyperexcitability and epileptogenesis. | Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability.
Hill JL, Jimenez DV, Mai Y, Ren M, Hallock HL, Maynard KR, Chen HY, Hardy NF, Schloesser RJ, Maher BJ, Yang F, Martinowich K., Free PMC Article | 06/1/2019 |
| Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice. | Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.
Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP., Free PMC Article | 06/2/2018 |
| Endogenous SST and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status). | Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.
Luque RM, Villa-Osaba A, L-López F, Pozo-Salas AI, Sánchez-Sánchez R, Ortega-Salas R, de Lecea L, Álvarez-Benito M, López-Miranda J, Gahete MD, Castaño JP., Free PMC Article | 10/8/2016 |
| This study demonistrated that Cortistatin attenuates inflammatory pain via spinal and peripheral actions. | Cortistatin attenuates inflammatory pain via spinal and peripheral actions.
Morell M, Camprubí-Robles M, Culler MD, de Lecea L, Delgado M. | 09/20/2014 |
| endogenous CORT is essential for the obesity-induced changes in insulin expression/secretion observed in mice | Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions.
Chanclón B, Luque RM, Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Gracia-Navarro F, Martínez-Fuentes AJ., Free PMC Article | 08/31/2013 |
| Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation. | Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Duran-Prado M, Morell M, Delgado-Maroto V, Castaño JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O'Valle F, Delgado M. | 07/27/2013 |
| the role of endogenous CST is different from SST; CST exerted an unexpected stimulatory role on prolactin secretion | Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.
Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Martínez-Fuentes AJ, de Lecea L, Gracia-Navarro F, Kineman RD, Castaño JP, Luque RM., Free PMC Article | 02/18/2012 |
| Regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior. | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior.
Martinowich K, Schloesser RJ, Jimenez DV, Weinberger DR, Lu B., Free PMC Article | 07/30/2011 |
| Cortistatin mRNA concentration in the hippocampus and dentate gyrus is significantly increased in aged non-transgenic (Tg) mice compared with young non-Tg mice. | Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice.
Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L, Criado JR. | 01/21/2010 |