| the C2B domain of syt1, independent of complexin, is the molecular clamp that arrests synaptic vesicles prior to Ca(2+)-triggered fusion. | Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
Courtney NA, Bao H, Briguglio JS, Chapman ER., Free PMC Article | 12/21/2019 |
| The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein. | Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.
Gispert S, Kurz A, Brehm N, Rau K, Walter M, Riess O, Auburger G., Free PMC Article | 05/21/2016 |
| In the absence of Cplx1, synaptic vesicles remain unstable and prone to premature fusion. | Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.
Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H., Free PMC Article | 08/22/2015 |
| Cplx 1 and 2 play a role in facilitating vesicle priming, and also lead to the new hypothesis that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels. | Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems.
Lin MY, Rohan JG, Cai H, Reim K, Ko CP, Chow RH., Free PMC Article | 12/7/2013 |
| Complexin-1 carboxyl-terminal domain binds lipids through a novel protein motif by targeting complexin-1 to synaptic vesicles. | Synaptic vesicles position complexin to block spontaneous fusion.
Wragg RT, Snead D, Dong Y, Ramlall TF, Menon I, Bai J, Eliezer D, Dittman JS., Free PMC Article | 03/23/2013 |
| the ataxia in Cplx1(-/-) mice is likely to be due to pathological changes in both cerebellum and thalamus | Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.
Kielar C, Sawiak SJ, Navarro Negredo P, Tse DH, Morton AJ., Free PMC Article | 07/28/2012 |
| These results suggest a complexin-dependent molecular mechanism for regulating AMPAR delivery to synapses | Postsynaptic complexin controls AMPA receptor exocytosis during LTP.
Ahmad M, Polepalli JS, Goswami D, Yang X, Kaeser-Woo YJ, Südhof TC, Malenka RC., Free PMC Article | 07/21/2012 |
| This study demonistrated that relatively large C-terminal complexin-1 sequence acts in priming and clamping synaptic exocytosis and demonstrate that the clamping function | C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis.
Kaeser-Woo YJ, Yang X, Südhof TC., Free PMC Article | 04/21/2012 |
| The study uncovers an interaction between the complexin-1 N terminus and the SNARE complex C terminus, and shows that disrupting this interaction abolishes the facilitatory function of complexins in mouse neurons. | Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.
Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C., Free PMC Article | 05/31/2010 |
| Complexin 1 is required for faithful processing of sound onset and offset in the cochlear nucleus. | Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.
Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, Moser T., Free PMC Article | 01/21/2010 |
| study shows in neuronal synapses, complexin simultaneously suppressed spontaneous membrane fusion & activated fast calcium ion-evoked fusion; complexin probably activates & clamps force transfer from assembled trans-SNARE complexes onto fusing membranes | Complexin controls the force transfer from SNARE complexes to membranes in fusion.
Maximov A, Tang J, Yang X, Pang ZP, Südhof TC., Free PMC Article | 01/21/2010 |
| Data show that Cplx1 in the locus Rgcs1 region is highly expressed in the ganglion cell layer and optic nerve head. | Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.
Dietz JA, Li Y, Chung LM, Yandell BS, Schlamp CL, Nickells RW., Free PMC Article | 01/21/2010 |
| Results indicate that distinct functional domains of copmplexin I differentially regulate synaptic exocytosis, and that CplxI carries out a crucial role in fine-tuning Ca2+-triggered fast neurotransmitter release. | Distinct domains of complexin I differentially regulate neurotransmitter release.
Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C., Free PMC Article | 01/21/2010 |
| Complexin 1 knockout mice have pronounced deficits in social behaviours in addition to the severe motor and exploratory deficits. | Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.
Drew CJ, Kyd RJ, Morton AJ. | 01/21/2010 |
| complexin I functions in exocytosis in two related but morphologically distinct secretory processes. | Complexin I is required for mammalian sperm acrosomal exocytosis.
Zhao L, Burkin HR, Shi X, Li L, Reim K, Miller DJ., Free PMC Article | 01/21/2010 |
| Its co-localization and interaction with complexin I suggest that dynamin 2 may play a role during acrosome formation and/or acrosomal exocytosis. | Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm.
Zhao L, Shi X, Li L, Miller DJ. | 01/21/2010 |
| We studied the mRNA distribution of CPLXI and CPLXII in mouse brain. We show that while CPLXs are expressed in distinct cell populations they do not segregate with particular neurotransmitters or different classes of transmitter action | Differential messenger RNA expression of complexins in mouse brain.
Freeman W, Morton AJ. | 01/21/2010 |
| Here we propose that complexin binding activates SNARE complexes into a metastable state and that Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis by displacing complexin from metastable SNARE complexes. | A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Südhof TC. | 01/21/2010 |
| CPX I plays a critical role in beta-cells in the control of the stimulated-exocytosis of insulin. | Complexin I regulates glucose-induced secretion in pancreatic beta-cells.
Abderrahmani A, Niederhauser G, Plaisance V, Roehrich ME, Lenain V, Coppola T, Regazzi R, Waeber G. | 01/21/2010 |
| early behavioural development of Cplx1(-/-) mice showed marked abnormalities | Early motor development is abnormal in complexin 1 knockout mice.
Glynn D, Sizemore RJ, Morton AJ. | 01/21/2010 |