| Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation. | Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
Chen J, Qin H, Hao J, Wang Q, Chen S, Yang G, Li M, Zhu X, Wang D, Chen H, Cui C, Chen M. | 04/16/2024 |
| Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. | Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation.
Seidl MD, Fels B, Kranick D, Sternberg A, Grimm K, Stümpel FT, Pluteanu F, Schulte JS, Heinick A, Kojima N, Endo S, Huge A, Stoll M, Müller FU. | 02/27/2021 |
| Novel insights into biological roles of inducible cAMP early repressor ICER. | Novel insights into biological roles of inducible cAMP early repressor ICER.
Režen T, Zmrzljak UP, Bensa T, Tomaš TC, Cirnski K, Stojan J, Rozman D. | 02/27/2021 |
| CREM-/- mice were more susceptible to E. histolytica amebic colitis | Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.
Wojcik GL, Marie C, Abhyankar MM, Yoshida N, Watanabe K, Mentzer AJ, Carstensen T, Mychaleckyj J, Kirkpatrick BD, Rich SS, Concannon P, Haque R, Tsokos GC, Petri WA Jr, Duggal P., Free PMC Article | 03/9/2019 |
| Studied role and importance of inducible cAMP early repressor (ICER) in glutaminolysis and the generation of Th17 cells. Demonstrated the IL-17 promoting ICER works through the direct control of glutaminase 1 (Gls1) by binding its promoter. | Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.
Kono M, Yoshida N, Maeda K, Tsokos GC., Free PMC Article | 08/4/2018 |
| Deficiency in ICER elevated binding of NF-kappaB to promoters of pro-inflammatory genes and their subsequent gene expression. Mice deficient in ICER were hypersensitive to LPS-induced endotoxic shock and showed propagated inflammation. | A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses.
Lv S, Li J, Qiu X, Li W, Zhang C, Zhang ZN, Luan B., Free PMC Article | 01/20/2018 |
| The transcription factor CREM was found to be important in the regulation of cardiotoxicity-associated genes. | Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia.
Barbati SA, Colussi C, Bacci L, Aiello A, Re A, Stigliano E, Isidori AM, Grassi C, Pontecorvi A, Farsetti A, Gaetano C, Nanni S. | 09/30/2017 |
| Our results demonstrate that overexpression of CREMalpha in T cells changes the inflammatory milieu, attenuating initiation and progression of CLD. | Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease.
Kuttkat N, Mohs A, Ohl K, Hooiveld G, Longerich T, Tenbrock K, Cubero FJ, Trautwein C., Free PMC Article | 07/15/2017 |
| the role of ICER in ovarian function, was investigated. | The transcriptional repressor ICER binds to multiple loci throughout the genome.
Muñiz LC, Molina CA., Free PMC Article | 06/3/2017 |
| Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117. | Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117.
Fu G, Wei Y, Wang X, Yu L. | 01/28/2017 |
| the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression. | GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.
Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB., Free PMC Article | 12/17/2016 |
| Crem(-/-) mice exhibited increased proliferation of primary aortic VSMCs along with upregulation of PDGF signaling. | Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice.
Seidl MD, Steingräber AK, Wolf CT, Sur TM, Hildebrandt I, Witten A, Stoll M, Fischer JW, Schmitz W, Müller FU., Free PMC Article | 07/2/2016 |
| overexpressed in the nuclei of hepatocellular carcinoma cells | Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver.
Ella E, Heim D, Stoyanov E, Harari-Steinfeld R, Steinfeld I, Pappo O, Perlman TS, Nachmansson N, Rivkin L, Olam D, Abramovitch R, Wege H, Galun E, Goldenberg D., Free PMC Article | 08/1/2015 |
| Unlike in T cells from spleen, CREMalpha overexpression did not induce a predominant Th17 response in intrahepatic T cells | Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice.
Hammerich L, Warzecha KT, Stefkova M, Bartneck M, Ohl K, Gassler N, Luedde T, Trautwein C, Tenbrock K, Tacke F. | 04/25/2015 |
| These data identify ICER as a redundant mediator of Treg cells and cAMP action on Teff cells and suggest that Epac may function as an alternative effector to promote cAMP-dependent Teff cell suppression. | Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. | 02/14/2015 |
| CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. | CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC., Free PMC Article | 06/21/2014 |
| CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a. | cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC., Free PMC Article | 03/29/2014 |
| The results of this study suggested that activation of CREMtau may provide a means to accelerate the therapeutic efficacy of current antidepressant treatment. | Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τ.
Gundersen BB, Briand LA, Onksen JL, Lelay J, Kaestner KH, Blendy JA., Free PMC Article | 11/2/2013 |
| levels of CREM in T cells determine the outcome of acute lung injury, and CREMalpha transgenic animals represent a model in which proinflammatory T cells aggravate acute lung injury in different phases of the disease. | Overexpression of CREMα in T cells aggravates lipopolysaccharide-induced acute lung injury.
Verjans E, Ohl K, Yu Y, Lippe R, Schippers A, Wiener A, Roth J, Wagner N, Uhlig S, Tenbrock K, Martin C. | 10/19/2013 |
| Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles. | Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles.
Haefliger JA, Martin D, Favre D, Petremand Y, Mazzolai L, Abderrahmani A, Meda P, Waeber G, Allagnat F., Free PMC Article | 07/27/2013 |
| Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks. | Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.
Zmrzljak UP, Korenčič A, Košir R, Goličnik M, Sassone-Corsi P, Rozman D., Free PMC Article | 06/8/2013 |
| Data suggest that expression of TRH (thyrotropin-releasing hormone) is up-regulated by CREM in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of expression of CREM or CREB (cAMP responsive element binding protein). | Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.
Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN., Free PMC Article | 04/20/2013 |
| analysis of insights into the downstream pathways and targets controlled by transcription factors CREM in the testis | Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.
Kosir R, Juvan P, Perse M, Budefeld T, Majdic G, Fink M, Sassone-Corsi P, Rozman D., Free PMC Article | 09/1/2012 |
| CREMalpha overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity. | CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.
Lippe R, Ohl K, Varga G, Rauen T, Crispin JC, Juang YT, Kuerten S, Tacke F, Wolf M, Roebrock K, Vogl T, Verjans E, Honke N, Ehrchen J, Foell D, Skryabin B, Wagner N, Tsokos GC, Roth J, Tenbrock K. | 08/18/2012 |
| Impaired expression of ICER contributes to elevation in CREB target genes and, therefore, to the development of insulin resistance in obesity. | Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity.
Favre D, Le Gouill E, Fahmi D, Verdumo C, Chinetti-Gbaguidi G, Staels B, Caiazzo R, Pattou F, Lê KA, Tappy L, Regazzi R, Giusti V, Vollenweider P, Waeber G, Abderrahmani A., Free PMC Article | 02/4/2012 |