| The cAMP receptor protein gene contributes to growth, stress resistance, and colonization of Actinobacillus pleuropneumoniae. | The cAMP receptor protein gene contributes to growth, stress resistance, and colonization of Actinobacillus pleuropneumoniae.
He Q, Zheng Y, Yan K, Tang J, Yang F, Tian Y, Yang L, Dou B, Chen Y, Gu J, Chen H, Yuan F, Bei W. | 02/21/2024 |
| C-reactive protein impairs immune response of CD8[+] T cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma. | C-reactive protein impairs immune response of CD8(+) T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma.
Jiang J, Peng Z, Wang J, Chen M, Wan Y, Huang H, Liu Z, Wang J, Hou J., Free PMC Article | 10/24/2023 |
| Innate Immune Zonation in the Liver: NF-kappaB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific. | Innate Immune Zonation in the Liver: NF-κB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.
McCarthy WC, Sherlock LG, Grayck MR, Zheng L, Lacayo OA, Solar M, Orlicky DJ, Dobrinskikh E, Wright CJ., Free PMC Article | 04/19/2023 |
| Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes. | Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes.
Ruiz-Fernández C, Gonzalez-Rodríguez M, Francisco V, Rajab IM, Gómez R, Conde J, Lago F, Pino J, Mobasheri A, Gonzalez-Gay MA, Mera A, Potempa LA, Gualillo O. | 01/1/2022 |
| C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis. | C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis.
Shen ZY, Zheng Y, Pecsok MK, Wang K, Li W, Gong MJ, Wu F, Zhang L., Free PMC Article | 07/3/2021 |
| this study shows that C-reactive protein impairs dendritic cell development, maturation, and function | C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance.
Jimenez RV, Wright TT, Jones NR, Wu J, Gibson AW, Szalai AJ., Free PMC Article | 04/13/2019 |
| CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. | C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.
You YK, Huang XR, Chen HY, Lyu XF, Liu HF, Lan HY., Free PMC Article | 04/7/2018 |
| FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation. | Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes.
Nakai K, Tanaka H, Yamanaka K, Takahashi Y, Murakami F, Matsuike R, Sekino J, Tanabe N, Morita T, Yamazaki Y, Kawato T, Maeno M., Free PMC Article | 03/3/2018 |
| C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex. | C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
Lai W, Tang Y, Huang XR, Ming-Kuen Tang P, Xu A, Szalai AJ, Lou TQ, Lan HY., Free PMC Article | 10/21/2017 |
| These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways. | C‑reactive protein/oxidized low density lipoprotein/β2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑activated protein kinase and nuclear factor‑κB signaling pathways.
Wang J, Feng MJ, Zhang R, Yu DM, Zhou SJ, Chen R, Yu P. | 04/22/2017 |
| these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP. | An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein.
Li HY, Wang J, Meng F, Jia ZK, Su Y, Bai QF, Lv LL, Ma FR, Potempa LA, Yan YB, Ji SR, Wu Y., Free PMC Article | 10/8/2016 |
| CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway. | C-reactive protein inhibits high-molecular-weight adiponectin expression in 3T3-L1 adipocytes via PI3K/Akt pathway.
Liu Y, Liu C, Jiang C, Wang S, Yang Q, Jiang D, Yuan G. | 08/6/2016 |
| mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia. | Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia?
Slevin M, Matou S, Zeinolabediny Y, Corpas R, Weston R, Liu D, Boras E, Di Napoli M, Petcu E, Sarroca S, Popa-Wagner A, Love S, Font MA, Potempa LA, Al-Baradie R, Sanfeliu C, Revilla S, Badimon L, Krupinski J., Free PMC Article | 07/30/2016 |
| Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells | Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells.
Jin Y, Cao J, Xu X, Ye X, Chen Y, Yang J, Feng Q, Zhu L, Qian X, Yang C. | 06/28/2016 |
| These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways. | Effects of C-reactive protein on bone cells.
Cho IJ, Choi KH, Oh CH, Hwang YC, Jeong IK, Ahn KJ, Chung HY. | 06/28/2016 |
| Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. | DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
Cox N, Pilling D, Gomer RH., Free PMC Article | 10/31/2015 |
| the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo | C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia.
Kapur R, Heitink-Pollé KM, Porcelijn L, Bentlage AE, Bruin MC, Visser R, Roos D, Schasfoort RB, de Haas M, van der Schoot CE, Vidarsson G. | 06/27/2015 |
| CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. | C-reactive protein reduces the relative number of tumor-associated M2 macrophages and intratumoral angiogenesis in mice.
Kuribayashi K, Motoyama S, Sasaki T, Sato Y, Yoshino K, Wakita A, Imai K, Saito H, Minamiya Y. | 04/4/2015 |
| Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. | Orphan nuclear receptor Errγ induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
Misra J, Chanda D, Kim DK, Cho SR, Koo SH, Lee CH, Back SH, Choi HS., Free PMC Article | 11/8/2014 |
| The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function. | C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation.
Hsuchou H, Kastin AJ, Mishra PK, Pan W., Free PMC Article | 09/13/2014 |
| Radiation combined injury-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival. | Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation.
Kiang JG, Ledney GD., Free PMC Article | 05/17/2014 |
| In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma. | Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells.
Saiki R, Hayashi D, Ikuo Y, Nishimura K, Ishii I, Kobayashi K, Chiba K, Toida T, Kashiwagi K, Igarashi K. | 05/17/2014 |
| CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice. | C-reactive protein inhibits lymphangiogenesis and resultant lymph node metastasis of squamous cell carcinoma in mice.
Sasaki T, Motoyama S, Sato Y, Yoshino K, Matsumoto G, Minamiya Y, Saito H, Murata K, Ogawa J. | 12/21/2013 |
| Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle. | C-reactive protein causes insulin resistance in mice through Fcγ receptor IIB-mediated inhibition of skeletal muscle glucose delivery.
Tanigaki K, Vongpatanasin W, Barrera JA, Atochin DN, Huang PL, Bonvini E, Shaul PW, Mineo C., Free PMC Article | 04/20/2013 |
| CRP is not only a biomarker, but also a mediator in DKD. | C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY. | 04/28/2012 |