| CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury. | CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury.
Qi T, Xu X, Guo Y, Xia Y, Peng L, Li C, Ding F, Gao C, Fan M, Yu M, Zhao H, He Y, Li W, Hai C, Gao E, Zhang X, Gao F, Fan Y, Yan W, Tao L., Free PMC Article | 04/19/2023 |
| The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML. | The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.
Charlet A, Kappenstein M, Keye P, Kläsener K, Endres C, Poggio T, Gorantla SP, Kreutmair S, Sänger J, Illert AL, Miething C, Reth M, Duyster J, Rummelt C, von Bubnoff N., Free PMC Article | 03/12/2022 |
| This study demonstrates that induced pluripotent stem cell-derived macrophages effectively treat pulmonary alveolar proteinosis in Csf2rb-deficient mice after pulmonary transplantation. | iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
Mucci A, Lopez-Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, Ackermann M, Kempf H, Hillje R, Kunkiel J, Janosz E, Brennig S, Glage S, Bankstahl JP, Dettmer S, Rodt T, Gohring G, Trapnell B, Hansen G, Trapnell C, Knudsen L, Lachmann N, Moritz T., Free PMC Article | 09/21/2019 |
| IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis. | Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.
Vu T, Austin R, Kuhn CP, Bruedigam C, Song A, Guignes S, Jacquelin S, Ramshaw HS, Hill GR, Lopez AF, Lane SW., Free PMC Article | 01/14/2017 |
| blockage of betaCR abrogated the EPO-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2 | β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.
Lee TS, Lu KY, Yu YB, Lee HT, Tsai FC., Free PMC Article | 06/11/2016 |
| Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice. | Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.
Zhang J, Ranheim EA, Du J, Liu Y, Wang J, Kong G, Zhang J., Free PMC Article | 10/24/2015 |
| Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE(-/-) BM-transplanted Ldlr(-/-) mice, contributing to monocytosis and increased lesional macrophage content. | Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency.
Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR., Free PMC Article | 06/21/2014 |
| Erythropoietin attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor. | Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor.
Khan AI, Coldewey SM, Patel NS, Rogazzo M, Collino M, Yaqoob MM, Radermacher P, Kapoor A, Thiemermann C., Free PMC Article | 10/26/2013 |
| Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor. | SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
Hidano S, Kitamura D, Kumar L, Geha RS, Goitsuka R. | 04/13/2013 |
| Csf-2 receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103(+) & CD11b(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries. | GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M., Free PMC Article | 09/15/2012 |
| GM-CSF can regulate beta-catenin stability, most likely via GSK3b. | The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.
Brown AL, Salerno DG, Sadras T, Engler GA, Kok CH, Wilkinson CR, Samaraweera SE, Sadlon TJ, Perugini M, Lewis ID, Gonda TJ, D'Andrea RJ., Free PMC Article | 03/24/2012 |
| Suggest that beta common receptor may play an integrative role in the erythropoietin signaling-mediated activation of eNOS in endothelial cells. | β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase.
Su KH, Shyue SK, Kou YR, Ching LC, Chiang AN, Yu YB, Chen CY, Pan CC, Lee TS. | 11/19/2011 |
| NF-kappaB activation by beta(c) is dependent on TNFR-associated factor (TRAF)6; association of TRAF6 with beta(c) requires a consensus-binding motif found in other molecules known to interact with TRAF6. | A novel TNF receptor-associated factor 6 binding domain mediates NF-kappa B signaling by the common cytokine receptor beta subunit.
Meads MB, Li ZW, Dalton WS., Free PMC Article | 09/13/2010 |
| Although endogenous GM-CSF is not required to induce tumor immunity, signaling through betac receptor is critically needed for efficient cancer vaccination in both genetically modified GM-CSF-secreting tumor cells and a spontaneously immunogenic models. | Role of GM-CSF signaling in cell-based tumor immunization.
Zarei S, Schwenter F, Luy P, Aurrand-Lions M, Morel P, Kopf M, Dranoff G, Mach N., Free PMC Article | 01/21/2010 |
| Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. | Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation.
Murphy JM, Soboleva TA, Mirza S, Ford SC, Olsen JE, Chen J, Young IG. | 01/21/2010 |
| A previously unrecognized negative signaling role for Tyr577 in beta(c); uncoupling Shc from cytokine receptors enhances PI3K signaling as well as survival and proliferation. | The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
Ramshaw HS, Guthridge MA, Stomski FC, Barry EF, Ooms L, Mitchell CA, Begley CG, Lopez AF., Free PMC Article | 01/21/2010 |
| Interleukin-3 binding to the murine betaIL-3 receptor involves functional epitopes formed by domains 1 and 4 of different protein chains | Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.
Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG. | 01/21/2010 |